31 items (Anopheles darlingi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_001855	Histone H3; Belongs to the histone H3 family. (136 aa)
	AND_009797	Histone H2A; Belongs to the histone H2A family. (126 aa)
	AND_010578	Metastasis-associated protein MTA. (945 aa)
	AND_008848	Retinoblastoma-binding protein 4 (Rbbp4). (429 aa)
	AND_010332	Uncharacterized protein. (6844 aa)
	AND_008707	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (432 aa)
	AND_009033	Uncharacterized protein. (674 aa)
	AND_010092	Lysine-specific histone demethylase. (921 aa)
	AND_009867	Methyl-cpg binding protein, mbd. (316 aa)
	AND_009068	Breast cancer metastasis-suppressor. (236 aa)
	AND_008155	Sin3b. (2132 aa)
	AND_006680	P66_CC domain-containing protein. (845 aa)
	AND_007863	Chromodomain helicase DNA binding protein. (2184 aa)
	AND_006363	Histone H2A; Belongs to the histone H2A family. (139 aa)
	AND_006902	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (491 aa)
	AND_006366	Histone H2B; Belongs to the histone H2B family. (124 aa)
	AND_004713	Histone acetyltransferase type B catalytic subunit. (422 aa)
	AND_006124	Histone H3; Belongs to the histone H3 family. (136 aa)
	AND_001856	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	AND_004029	Inhibitor of growth protein. (591 aa)
	AND_004775	REST corepressor. (626 aa)
	AND_003510	Phd finger. (1112 aa)
	AND_003229	Bromo domain-containing protein. (2589 aa)
	AND_003225	Sap30. (174 aa)
	AND_001486	Chromodomain helicase DNA binding protein. (2227 aa)
	AND_000499	Histone deacetylase. (1119 aa)
	AND_000362	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1180 aa)
	AND_001011	Suppressor of defective silencing. (390 aa)
	AND_001156	Retained. (155 aa)
	AND_000400	Helicase. (677 aa)
	AND_000299	TPR_REGION domain-containing protein. (443 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000299	AND_001855	W5JX68	E3WLC5	TPR_REGION domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.901
AND_000299	AND_001856	W5JX68	W5JH29	TPR_REGION domain-containing protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.967
AND_000299	AND_004713	W5JX68	W5JGT5	TPR_REGION domain-containing protein.	Histone acetyltransferase type B catalytic subunit.	0.994
AND_000299	AND_006124	W5JX68	W5JGZ9	TPR_REGION domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.901
AND_000299	AND_006363	W5JX68	W5JF56	TPR_REGION domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.660
AND_000299	AND_006366	W5JX68	W5JGP1	TPR_REGION domain-containing protein.	Histone H2B; Belongs to the histone H2B family.	0.898
AND_000299	AND_006902	W5JX68	W5JF61	TPR_REGION domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.420
AND_000299	AND_008707	W5JX68	W5J5F1	TPR_REGION domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.420
AND_000299	AND_008848	W5JX68	W5J4Z6	TPR_REGION domain-containing protein.	Retinoblastoma-binding protein 4 (Rbbp4).	0.975
AND_000362	AND_000400	W5JUI4	W5JW64	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Helicase.	0.683
AND_000362	AND_001011	W5JUI4	W5JVT6	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Suppressor of defective silencing.	0.838
AND_000362	AND_001156	W5JUI4	W5JVW9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Retained.	0.661
AND_000362	AND_001486	W5JUI4	W5JRF8	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromodomain helicase DNA binding protein.	0.795
AND_000362	AND_001855	W5JUI4	E3WLC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone H3; Belongs to the histone H3 family.	0.783
AND_000362	AND_001856	W5JUI4	W5JH29	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.860
AND_000362	AND_003225	W5JUI4	W5JQK1	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Sap30.	0.771
AND_000362	AND_003229	W5JUI4	W5JQH3	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Bromo domain-containing protein.	0.648
AND_000362	AND_003510	W5JUI4	W5JPC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Phd finger.	0.987
AND_000362	AND_004029	W5JUI4	W5JIM6	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Inhibitor of growth protein.	0.722
AND_000362	AND_004775	W5JUI4	W5JJN4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	REST corepressor.	0.852