19 items (Anopheles darlingi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	AND_010024	Male-specific lethal-3. (493 aa)
	AND_009248	Uncharacterized protein. (882 aa)
	AND_010578	Metastasis-associated protein MTA. (945 aa)
	AND_000362	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1180 aa)
	AND_008848	Retinoblastoma-binding protein 4 (Rbbp4). (429 aa)
	AND_001011	Suppressor of defective silencing. (390 aa)
	AND_000499	Histone deacetylase. (1119 aa)
	AND_003732	Wd-repeat protein. (504 aa)
	AND_004775	REST corepressor. (626 aa)
	AND_005360	Histone deacetylase. (354 aa)
	AND_006902	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (491 aa)
	AND_007963	Chromo domain protein. (418 aa)
	AND_008138	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (313 aa)
	AND_008155	Sin3b. (2132 aa)
	AND_009068	Breast cancer metastasis-suppressor. (236 aa)
	AND_009244	Chromatin regulatory protein sir2. (556 aa)
	AND_009861	Chromatin regulatory protein sir2. (586 aa)
	AND_008496	Chromatin regulatory protein sir2. (353 aa)
	AND_008707	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (432 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000362	AND_001011	W5JUI4	W5JVT6	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Suppressor of defective silencing.	0.838
AND_000362	AND_003732	W5JUI4	W5JNQ3	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Wd-repeat protein.	0.735
AND_000362	AND_004775	W5JUI4	W5JJN4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	REST corepressor.	0.852
AND_000362	AND_005360	W5JUI4	W5JJK0	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase.	0.656
AND_000362	AND_006902	W5JUI4	W5JF61	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.857
AND_000362	AND_007963	W5JUI4	W5JC63	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromo domain protein.	0.844
AND_000362	AND_008138	W5JUI4	W5JBK9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.598
AND_000362	AND_008155	W5JUI4	W5J9T7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Sin3b.	0.926
AND_000362	AND_008496	W5JUI4	W5J661	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromatin regulatory protein sir2.	0.554
AND_000362	AND_008707	W5JUI4	W5J5F1	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.858
AND_000362	AND_008848	W5JUI4	W5J4Z6	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Retinoblastoma-binding protein 4 (Rbbp4).	0.919
AND_000362	AND_009068	W5JUI4	W5J8Y1	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Breast cancer metastasis-suppressor.	0.838
AND_000362	AND_009244	W5JUI4	W5J6V3	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromatin regulatory protein sir2.	0.489
AND_000362	AND_009248	W5JUI4	W5J416	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Uncharacterized protein.	0.489
AND_000362	AND_009861	W5JUI4	W5J6U2	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromatin regulatory protein sir2.	0.751
AND_000362	AND_010024	W5JUI4	W5J3E8	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Male-specific lethal-3.	0.822
AND_000362	AND_010578	W5JUI4	W5J4W5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Metastasis-associated protein MTA.	0.846
AND_000499	AND_001011	W5JU68	W5JVT6	Histone deacetylase.	Suppressor of defective silencing.	0.838
AND_000499	AND_003732	W5JU68	W5JNQ3	Histone deacetylase.	Wd-repeat protein.	0.735
AND_000499	AND_004775	W5JU68	W5JJN4	Histone deacetylase.	REST corepressor.	0.890