(24 nodes) Stem cell differentiation network (Anopheles darlingi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_007013	Scaffold protein salvador (Shar-pei). (463 aa)
	AND_000197	Gremlin-1. (333 aa)
	AND_000994	Pef protein with a long n-terminal hydrophobic domain (Peflin). (212 aa)
	AND_000441	XPA-binding protein 2. (867 aa)
	AND_000546	Uncharacterized protein. (116 aa)
	AND_003659	Notch. (2296 aa)
	AND_003548	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
	AND_002321	Uncharacterized protein. (320 aa)
	AND_010198	T-box transcription factor tbx20. (293 aa)
	AND_002379	Ku P80 DNA helicase. (728 aa)
	AND_003906	Uncharacterized protein. (1024 aa)
	AND_003589	Frizzled; Belongs to the G-protein coupled receptor Fz/Smo family. (702 aa)
	AND_003907	Scribbled. (753 aa)
	AND_004417	T-box transcription factor tbx20. (639 aa)
	AND_005874	Uncharacterized protein. (468 aa)
	AND_005231	Receptor protein-tyrosine kinase. (1494 aa)
	AND_005253	Nuclear receptor subfamily 2 group F member 3. (805 aa)
	AND_009674	GATAa2 transcription factor. (534 aa)
	AND_010203	Uncharacterized protein. (189 aa)
	AND_010175	Fibrinogen C-terminal domain-containing protein. (1122 aa)
	AND_010219	T-box transcription factor tbx20. (139 aa)
	AND_009667	GATA transcription factor (GATAd). (708 aa)
	AND_009525	Uncharacterized protein. (496 aa)
	AND_006946	Smad anchor for receptor activation. (1415 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000441	AND_003906	W5JW10	W5JM19	XPA-binding protein 2.	Uncharacterized protein.	0.422
AND_000441	AND_003907	W5JW10	W5JJ01	XPA-binding protein 2.	Scribbled.	0.422
AND_003548	AND_003589	W5JP77	W5JKJ4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled; Belongs to the G-protein coupled receptor Fz/Smo family.	0.987
AND_003548	AND_003659	W5JP77	W5JPA3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notch.	0.680
AND_003548	AND_005874	W5JP77	W5JHR2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.680
AND_003589	AND_003548	W5JKJ4	W5JP77	Frizzled; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.987
AND_003659	AND_003548	W5JPA3	W5JP77	Notch.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.680
AND_003659	AND_005231	W5JPA3	W5JG62	Notch.	Receptor protein-tyrosine kinase.	0.578
AND_003906	AND_000441	W5JM19	W5JW10	Uncharacterized protein.	XPA-binding protein 2.	0.422
AND_003906	AND_003907	W5JM19	W5JJ01	Uncharacterized protein.	Scribbled.	0.584
AND_003906	AND_005231	W5JM19	W5JG62	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.724
AND_003907	AND_000441	W5JJ01	W5JW10	Scribbled.	XPA-binding protein 2.	0.422
AND_003907	AND_003906	W5JJ01	W5JM19	Scribbled.	Uncharacterized protein.	0.584
AND_003907	AND_005231	W5JJ01	W5JG62	Scribbled.	Receptor protein-tyrosine kinase.	0.724
AND_005231	AND_003659	W5JG62	W5JPA3	Receptor protein-tyrosine kinase.	Notch.	0.578
AND_005231	AND_003906	W5JG62	W5JM19	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.724
AND_005231	AND_003907	W5JG62	W5JJ01	Receptor protein-tyrosine kinase.	Scribbled.	0.724
AND_005231	AND_005253	W5JG62	W5JFA0	Receptor protein-tyrosine kinase.	Nuclear receptor subfamily 2 group F member 3.	0.748
AND_005231	AND_005874	W5JG62	W5JHR2	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.578
AND_005231	AND_009525	W5JG62	W5J7M4	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.627