(48 nodes) Toll Like Receptor TLR6:TLR2 Cascade network (Anopheles darlingi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_000781	Uncharacterized protein. (209 aa)
	AND_006215	Ubiquitin/60S ribosomal protein L40 fusion. (128 aa)
	AND_009872	Tak1; Belongs to the protein kinase superfamily. (385 aa)
	AND_009631	Dual specificity mitogen-activated protein kinase kinase 4 MAPKK4; Belongs to the protein kinase superfamily. (389 aa)
	AND_009884	TGF-beta activated kinase 1. (260 aa)
	AND_009085	Mitogen-activated protein kinase. (453 aa)
	AND_009987	Dual specificity mitogen-activated protein kinase kinase hemipterous MAPKK. (1139 aa)
	AND_009927	TNF-receptor-associated factor 6. (381 aa)
	AND_009089	Mitogen-activated protein kinase. (390 aa)
	AND_008101	Ubiquitin-conjugating enzyme E2 variant. (327 aa)
	AND_008689	Putative ribonuclease ZC3H12C. (847 aa)
	AND_009204	Ubiquitin. (77 aa)
	AND_008151	Mitogen-activated protein kinase. (775 aa)
	AND_007034	Mitogen-activated protein kinase. (412 aa)
	AND_007609	BZIP domain-containing protein. (427 aa)
	AND_006536	Ubiquitin. (78 aa)
	AND_007577	Serine/threonine protein phosphatase 2a regulatory subunit a. (962 aa)
	AND_007466	Protein kinase domain-containing protein. (550 aa)
	AND_007331	Uncharacterized protein. (1474 aa)
	AND_006534	Ubiquitin-5E. (154 aa)
	AND_005392	Uncharacterized protein. (521 aa)
	AND_005504	Non-specific serine/threonine protein kinase. (925 aa)
	AND_005933	Dual specificity mitogen-activated protein kinase kinase MAPKK; Belongs to the protein kinase superfamily. (375 aa)
	AND_005408	Inhibitor of nuclear factor kappa B kinase beta subunit. (800 aa)
	AND_005684	CCHC NOA-type domain-containing protein. (541 aa)
	AND_005178	Protein kinase domain-containing protein. (1506 aa)
	AND_003988	KxDL domain-containing protein. (247 aa)
	AND_003707	Uncharacterized protein. (315 aa)
	AND_004577	Tak1 binding protein-1. (533 aa)
	AND_003708	Uncharacterized protein. (262 aa)
	AND_003704	Dual specificity phosphatase. (394 aa)
	AND_003328	Ubiquitinyl hydrolase 1. (1052 aa)
	AND_003269	Pellino. (634 aa)
	AND_003940	BZIP domain-containing protein. (495 aa)
	AND_002691	Phosphatase 4. (1372 aa)
	AND_002697	Rel 2 protein, relish. (1180 aa)
	AND_003772	Uncharacterized protein. (473 aa)
	AND_002217	Testis/ seletal muscle dual specificty phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (214 aa)
	AND_001827	Serine/threonine-protein phosphatase. (309 aa)
	AND_003247	Putative ubiquitin-conjugating enzyme e2-17 kDa ubiquitin-conjugating enzyme e2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	AND_001686	Ubiquitin carboxyl-terminal hydrolase. (797 aa)
	AND_000593	RanBP2-type domain-containing protein. (1002 aa)
	AND_000238	RNase_Zc3h12a domain-containing protein. (474 aa)
	AND_001181	Cyclic-AMP response element binding protein. (387 aa)
	AND_000072	S6 kinase II beta. (329 aa)
	AND_001392	Rel1/Dif/Dorsal. (636 aa)
	AND_001131	Kappa b-ras. (226 aa)
	AND_000430	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily. (367 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000072	AND_001181	W5JV92	W5JUR4	S6 kinase II beta.	Cyclic-AMP response element binding protein.	0.910
AND_000072	AND_001392	W5JV92	W5JVH3	S6 kinase II beta.	Rel1/Dif/Dorsal.	0.679
AND_000072	AND_001827	W5JV92	W5JPS4	S6 kinase II beta.	Serine/threonine-protein phosphatase.	0.401
AND_000072	AND_002697	W5JV92	W5JN07	S6 kinase II beta.	Rel 2 protein, relish.	0.615
AND_000072	AND_003707	W5JV92	W5JJJ2	S6 kinase II beta.	Uncharacterized protein.	0.679
AND_000072	AND_003708	W5JV92	W5JK96	S6 kinase II beta.	Uncharacterized protein.	0.679
AND_000072	AND_003772	W5JV92	W5JNM0	S6 kinase II beta.	Uncharacterized protein.	0.755
AND_000072	AND_003940	W5JV92	W5JLZ1	S6 kinase II beta.	BZIP domain-containing protein.	0.510
AND_000072	AND_007034	W5JV92	W5JBD2	S6 kinase II beta.	Mitogen-activated protein kinase.	0.911
AND_000072	AND_007609	W5JV92	W5JBL6	S6 kinase II beta.	BZIP domain-containing protein.	0.755
AND_000072	AND_008151	W5JV92	W5J9V7	S6 kinase II beta.	Mitogen-activated protein kinase.	0.766
AND_000072	AND_009872	W5JV92	W5J2R5	S6 kinase II beta.	Tak1; Belongs to the protein kinase superfamily.	0.415
AND_000238	AND_005684	W5JUC7	W5JIA1	RNase_Zc3h12a domain-containing protein.	CCHC NOA-type domain-containing protein.	0.751
AND_000430	AND_001181	W5JW45	W5JUR4	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Cyclic-AMP response element binding protein.	0.778
AND_000430	AND_005408	W5JW45	W5JHY4	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase beta subunit.	0.601
AND_000430	AND_005933	W5JW45	W5JHV6	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase MAPKK; Belongs to the protein kinase superfamily.	0.812
AND_000430	AND_007034	W5JW45	W5JBD2	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.997
AND_000430	AND_008151	W5JW45	W5J9V7	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.610
AND_000430	AND_009085	W5JW45	W5J4C2	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.739
AND_000430	AND_009089	W5JW45	W5J7C7	Map kinase-activated protein kinase (Mapkapk); Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.726