(50 nodes) p75 NTR receptor-mediated signalling network (Anopheles darlingi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_000781	Uncharacterized protein. (209 aa)
	AND_006215	Ubiquitin/60S ribosomal protein L40 fusion. (128 aa)
	AND_010690	Uncharacterized protein. (632 aa)
	AND_010142	Triple functional. (635 aa)
	AND_010134	Guanine-nucleotide-exchange-factor. (1707 aa)
	AND_010060	Toll; Belongs to the Toll-like receptor family. (1377 aa)
	AND_009085	Mitogen-activated protein kinase. (453 aa)
	AND_010685	DH domain-containing protein. (2647 aa)
	AND_009078	Uncharacterized protein. (1893 aa)
	AND_009089	Mitogen-activated protein kinase. (390 aa)
	AND_008865	Leucine-rich transmembrane protein. (1066 aa)
	AND_009204	Ubiquitin. (77 aa)
	AND_009076	GTP-binding protein alpha subunit, gna. (416 aa)
	AND_007849	T-cell lymphoma invasion and metastasis. (1280 aa)
	AND_007908	Dbl. (468 aa)
	AND_006536	Ubiquitin. (78 aa)
	AND_006077	Reticulon-like protein. (436 aa)
	AND_005827	Ras GTP exchange factor, son of sevenless. (1869 aa)
	AND_007079	Uncharacterized protein. (519 aa)
	AND_006534	Ubiquitin-5E. (154 aa)
	AND_006308	Uncharacterized protein. (1346 aa)
	AND_006261	Rho guanine exchange factor. (1228 aa)
	AND_004896	RHO guanyl-nucleotide exchange factor. (1456 aa)
	AND_004665	Dynamin-associated protein. (1210 aa)
	AND_005427	Uncharacterized protein. (478 aa)
	AND_005467	Vav1. (353 aa)
	AND_005424	Uncharacterized protein. (613 aa)
	AND_003988	KxDL domain-containing protein. (247 aa)
	AND_003707	Uncharacterized protein. (315 aa)
	AND_003708	Uncharacterized protein. (262 aa)
	AND_002942	DH domain-containing protein. (858 aa)
	AND_003976	Uncharacterized protein. (464 aa)
	AND_002962	Guanine nucleotide exchange factor. (545 aa)
	AND_002945	DH domain-containing protein. (912 aa)
	AND_002916	Gtpase rho. (313 aa)
	AND_002782	Adam. (753 aa)
	AND_002697	Rel 2 protein, relish. (1180 aa)
	AND_002943	DH domain-containing protein. (1122 aa)
	AND_001451	DH domain-containing protein. (2842 aa)
	AND_003121	Uncharacterized protein. (670 aa)
	AND_002258	Guanine nucleotide exchange factor. (1104 aa)
	AND_001903	Uncharacterized protein. (1812 aa)
	AND_001005	Uncharacterized protein. (433 aa)
	AND_002253	Uncharacterized protein. (1392 aa)
	AND_000386	Breakpoint cluster region protein. (1609 aa)
	AND_001830	Still life. (813 aa)
	AND_000906	Chaoptin. (1321 aa)
	AND_001392	Rel1/Dif/Dorsal. (636 aa)
	AND_001084	Uncharacterized protein. (2247 aa)
	AND_000142	Rho guanine dissociation factor. (200 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000142	AND_000386	W5JWJ0	W5JTV2	Rho guanine dissociation factor.	Breakpoint cluster region protein.	0.467
AND_000142	AND_002916	W5JWJ0	W5JME1	Rho guanine dissociation factor.	Gtpase rho.	0.996
AND_000142	AND_006077	W5JWJ0	W5JDR3	Rho guanine dissociation factor.	Reticulon-like protein.	0.626
AND_000142	AND_006261	W5JWJ0	W5JGM1	Rho guanine dissociation factor.	Rho guanine exchange factor.	0.535
AND_000386	AND_000142	W5JTV2	W5JWJ0	Breakpoint cluster region protein.	Rho guanine dissociation factor.	0.467
AND_000386	AND_001084	W5JTV2	W5JW08	Breakpoint cluster region protein.	Uncharacterized protein.	0.527
AND_000386	AND_001830	W5JTV2	W5JUF3	Breakpoint cluster region protein.	Still life.	0.556
AND_000386	AND_002916	W5JTV2	W5JME1	Breakpoint cluster region protein.	Gtpase rho.	0.832
AND_000386	AND_003121	W5JTV2	W5JQT7	Breakpoint cluster region protein.	Uncharacterized protein.	0.500
AND_000386	AND_004896	W5JTV2	W5JH27	Breakpoint cluster region protein.	RHO guanyl-nucleotide exchange factor.	0.535
AND_000386	AND_005827	W5JTV2	W5JEJ6	Breakpoint cluster region protein.	Ras GTP exchange factor, son of sevenless.	0.401
AND_000386	AND_006261	W5JTV2	W5JGM1	Breakpoint cluster region protein.	Rho guanine exchange factor.	0.656
AND_000386	AND_007849	W5JTV2	W5J963	Breakpoint cluster region protein.	T-cell lymphoma invasion and metastasis.	0.556
AND_000781	AND_000906	W5JWM6	W5JVD5	Uncharacterized protein.	Chaoptin.	0.482
AND_000781	AND_001005	W5JWM6	W5JSS0	Uncharacterized protein.	Uncharacterized protein.	0.527
AND_000781	AND_001084	W5JWM6	W5JW08	Uncharacterized protein.	Uncharacterized protein.	0.513
AND_000781	AND_001392	W5JWM6	W5JVH3	Uncharacterized protein.	Rel1/Dif/Dorsal.	0.551
AND_000781	AND_002697	W5JWM6	W5JN07	Uncharacterized protein.	Rel 2 protein, relish.	0.597
AND_000781	AND_002916	W5JWM6	W5JME1	Uncharacterized protein.	Gtpase rho.	0.642
AND_000781	AND_003121	W5JWM6	W5JQT7	Uncharacterized protein.	Uncharacterized protein.	0.513