STRINGSTRING
AND_008848 AND_008848 AND_008458 AND_008458 AND_008874 AND_008874 AND_010002 AND_010002 AND_009504 AND_009504 AND_008410 AND_008410 AND_009328 AND_009328 AND_009310 AND_009310 AND_009786 AND_009786 AND_009726 AND_009726 MCM7 MCM7 AND_008431 AND_008431 AND_009614 AND_009614 AND_008370 AND_008370 AND_009479 AND_009479 AND_007674 AND_007674 AND_009204 AND_009204 AND_007844 AND_007844 AND_007813 AND_007813 AND_009038 AND_009038 AND_008899 AND_008899 AND_000525 AND_000525 AND_007610 AND_007610 AND_008203 AND_008203 AND_007392 AND_007392 AND_007380 AND_007380 AND_007978 AND_007978 AND_008478 AND_008478 AND_007010 AND_007010 AND_007811 AND_007811 AND_006536 AND_006536 AND_007631 AND_007631 AND_007608 AND_007608 AND_006086 AND_006086 AND_007577 AND_007577 AND_006108 AND_006108 AND_005973 AND_005973 AND_005572 AND_005572 AND_006583 AND_006583 AND_005559 AND_005559 AND_006534 AND_006534 AND_006902 AND_006902 AND_006351 AND_006351 AND_006319 AND_006319 AND_006038 AND_006038 AND_004872 AND_004872 AND_004858 AND_004858 AND_004739 AND_004739 AND_005862 AND_005862 AND_003926 AND_003926 AND_004997 AND_004997 AND_005496 AND_005496 AND_003988 AND_003988 AND_005056 AND_005056 AND_003809 AND_003809 AND_004480 AND_004480 AND_004448 AND_004448 AND_003453 AND_003453 AND_004298 AND_004298 AND_004877 AND_004877 AND_003338 AND_003338 AND_004067 AND_004067 AND_003221 AND_003221 AND_004457 AND_004457 AND_002691 AND_002691 AND_004306 AND_004306 AND_002536 AND_002536 AND_002522 AND_002522 AND_004016 AND_004016 AND_003950 AND_003950 AND_003867 AND_003867 AND_003365 AND_003365 AND_002229 AND_002229 AND_001827 AND_001827 AND_003255 AND_003255 AND_001537 AND_001537 AND_003089 AND_003089 AND_001535 AND_001535 AND_000920 AND_000920 AND_002299 AND_002299 AND_001644 AND_001644 AND_001637 AND_001637 AND_001623 AND_001623 AND_000762 AND_000762 AND_000733 AND_000733 AND_000716 AND_000716 AND_001949 AND_001949 AND_001536 AND_001536 AND_001991 AND_001991 AND_001304 AND_001304 AND_001581 AND_001581 AND_001696 AND_001696 AND_001632 AND_001632 AND_001018 AND_001018 AND_000092 AND_000092 AND_000045 AND_000045 AND_000760 AND_000760 AND_000681 AND_000681 AND_000667 AND_000667 AND_000781 AND_000781 AND_000364 AND_000364 AND_006215 AND_006215 AND_008850 AND_008850 AND_009925 AND_009925 AND_010165 AND_010165 AND_010372 AND_010372 AND_009254 AND_009254 AND_009125 AND_009125 AND_010533 AND_010533
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AND_008848Retinoblastoma-binding protein 4 (Rbbp4). (429 aa)
AND_008458Origin recognition complex subunit 3. (698 aa)
AND_008874Tyrosine-protein kinase. (739 aa)
AND_010002DNA replication licensing factor MCM1; Belongs to the MCM family. (1039 aa)
AND_009504Skp1; Belongs to the SKP1 family. (162 aa)
AND_008410Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
AND_009328DIRP domain-containing protein. (403 aa)
AND_009310DBF4-type domain-containing protein. (3659 aa)
AND_009786E2F_TDP domain-containing protein. (422 aa)
AND_00972626S proteasome non-ATPase regulatory subunit 6. (389 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (717 aa)
AND_008431Putative 26s proteasome regulatory complex subunit rpn11. (311 aa)
AND_009614Wee1-like protein kinase. (629 aa)
AND_00837026S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1051 aa)
AND_009479Cullin; Belongs to the cullin family. (778 aa)
AND_00767426S proteasome subunit S9. (416 aa)
AND_009204Ubiquitin. (77 aa)
AND_007844Origin recognition complex subunit 6. (266 aa)
AND_007813DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (524 aa)
AND_00903826S protease regulatory subunit; Belongs to the AAA ATPase family. (435 aa)
AND_008899Proteasome subunit beta type. (231 aa)
AND_000525Uncharacterized protein. (199 aa)
AND_007610Cyclin h; Belongs to the cyclin family. (333 aa)
AND_008203Proteasome subunit beta. (229 aa)
AND_007392Protein kinase domain-containing protein. (1003 aa)
AND_007380Tyrosine-protein kinase. (537 aa)
AND_007978Uncharacterized protein. (565 aa)
AND_00847826S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (899 aa)
AND_007010DIRP domain-containing protein. (591 aa)
AND_007811DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2234 aa)
AND_006536Ubiquitin. (78 aa)
AND_007631Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (471 aa)
AND_00760826S proteasome regulatory subunit S3. (495 aa)
AND_006086CDK-activating kinase assembly factor MAT1. (316 aa)
AND_007577Serine/threonine protein phosphatase 2a regulatory subunit a. (962 aa)
AND_006108Putative 26s protease regulatory subunit 6a; Belongs to the AAA ATPase family. (429 aa)
AND_005973Uncharacterized protein. (957 aa)
AND_005572Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (621 aa)
AND_006583Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (241 aa)
AND_005559Proteasome subunit beta. (205 aa)
AND_006534Ubiquitin-5E. (154 aa)
AND_006902Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (491 aa)
AND_006351Cyclin e; Belongs to the cyclin family. (564 aa)
AND_006319Proteasome regulatory subunit. (462 aa)
AND_006038CRC domain-containing protein. (818 aa)
AND_004872Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
AND_004858E2F_TDP domain-containing protein. (807 aa)
AND_004739DNA primase; Belongs to the eukaryotic-type primase small subunit family. (428 aa)
AND_005862Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
AND_003926Cyclin D2; Belongs to the cyclin family. (390 aa)
AND_004997DNA helicase; Belongs to the MCM family. (888 aa)
AND_005496S-phase kinase-associated protein 2. (386 aa)
AND_003988KxDL domain-containing protein. (247 aa)
AND_005056Cyclin a; Belongs to the cyclin family. (488 aa)
AND_003809Fibronectin type-III domain-containing protein 3a. (1446 aa)
AND_004480Phosphatase 2. (459 aa)
AND_004448Proteasome subunit beta. (287 aa)
AND_003453Cak1; Belongs to the protein kinase superfamily. (343 aa)
AND_004298Uncharacterized protein. (494 aa)
AND_004877Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
AND_003338Uncharacterized protein. (243 aa)
AND_00406726S protease regulatory subunit S10B; Belongs to the AAA ATPase family. (392 aa)
AND_00322126S proteasome non-ATPase regulatory subunit 13. (380 aa)
AND_004457DNA helicase; Belongs to the MCM family. (815 aa)
AND_002691Phosphatase 4. (1372 aa)
AND_004306Cell division protein kinase 4; Belongs to the protein kinase superfamily. (304 aa)
AND_002536Proteasome subunit beta. (205 aa)
AND_00252226S proteasome regulatory subunit 7, psd7. (338 aa)
AND_004016DNA polymerase. (1593 aa)
AND_003950Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
AND_003867Uncharacterized protein. (93 aa)
AND_003365J domain-containing protein. (292 aa)
AND_00222926S proteasome non-ATPase regulatory subunit 4. (411 aa)
AND_001827Serine/threonine-protein phosphatase. (309 aa)
AND_003255Proteasome subunit. (312 aa)
AND_001537Uncharacterized protein. (122 aa)
AND_003089Uncharacterized protein. (224 aa)
AND_001535Protein phosphatase 2 (Formerly 2A), regulatory subunit B. (1011 aa)
AND_000920Insect replication protein a. (245 aa)
AND_002299DNA replication factor Cdt1. (702 aa)
AND_001644Protein kinase domain-containing protein. (669 aa)
AND_001637DNA polymerase epsilon subunit 3. (127 aa)
AND_001623Putative 26s proteasome non-atpase regulatory subunit 8. (262 aa)
AND_000762DNA replication licensing factor MCM8; Belongs to the MCM family. (831 aa)
AND_000733Jak kinase hopscotch. (337 aa)
AND_000716DNA helicase; Belongs to the MCM family. (733 aa)
AND_001949PI31_Prot_N domain-containing protein. (256 aa)
AND_001536Uncharacterized protein. (725 aa)
AND_001991Cyclin N-terminal domain-containing protein. (633 aa)
AND_001304Transcription factor dp. (512 aa)
AND_001581DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (575 aa)
AND_001696Cdk1; Belongs to the protein kinase superfamily. (339 aa)
AND_001632Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (461 aa)
AND_001018M-phase inducer phosphatase 2. (919 aa)
AND_000092Uncharacterized protein. (501 aa)
AND_00004526S protease regulatory subunit; Belongs to the AAA ATPase family. (403 aa)
AND_000760Non-specific serine/threonine protein kinase. (621 aa)
AND_000681Tyrosine protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (656 aa)
AND_00066726S proteasome non-ATPase regulatory subunit 10. (260 aa)
AND_000781Uncharacterized protein. (209 aa)
AND_000364DNA helicase; Belongs to the MCM family. (873 aa)
AND_006215Ubiquitin/60S ribosomal protein L40 fusion. (128 aa)
AND_00885026S protease regulatory subunit 4; Belongs to the AAA ATPase family. (438 aa)
AND_009925Putative 26s protease regulatory subunit 6b; Belongs to the AAA ATPase family. (412 aa)
AND_010165Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
AND_010372Uncharacterized protein. (223 aa)
AND_009254DNA helicase; Belongs to the MCM family. (822 aa)
AND_009125Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (75 aa)
AND_010533Proteasome subunit beta. (279 aa)
Your Current Organism:
Anopheles darlingi
NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi
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