STRINGSTRING
AND_009244 AND_009244 AND_009583 AND_009583 AND_009516 AND_009516 AND_001856 AND_001856 AND_008291 AND_008291 AND_007678 AND_007678 AND_004541 AND_004541 AND_005738 AND_005738 AND_003988 AND_003988 AND_004822 AND_004822 AND_005246 AND_005246 AND_005056 AND_005056 AND_004468 AND_004468 AND_002618 AND_002618 AND_003844 AND_003844 AND_002533 AND_002533 AND_000682 AND_000682 AND_001696 AND_001696 AND_001203 AND_001203 AND_000205 AND_000205 AND_000781 AND_000781 AND_009204 AND_009204 AND_008837 AND_008837 AND_007036 AND_007036 AND_007799 AND_007799 AND_006224 AND_006224 AND_007997 AND_007997 AND_008542 AND_008542 AND_008265 AND_008265 AND_008137 AND_008137 AND_006316 AND_006316 AND_006536 AND_006536 AND_005572 AND_005572 AND_006534 AND_006534 AND_006315 AND_006315 AND_006487 AND_006487 AND_009909 AND_009909 AND_010064 AND_010064 AND_009880 AND_009880 AND_009248 AND_009248 AND_009395 AND_009395 AND_008496 AND_008496 AND_009917 AND_009917 AND_009916 AND_009916
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AND_009244Chromatin regulatory protein sir2. (556 aa)
AND_009583Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (334 aa)
AND_009516Serine/threonine-protein kinase grp. (509 aa)
AND_001856Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
AND_008291DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1029 aa)
AND_007678Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3165 aa)
AND_004541RAD51C protein. (330 aa)
AND_005738Uncharacterized protein. (323 aa)
AND_003988KxDL domain-containing protein. (247 aa)
AND_004822Spindle-b recombination protein spn-b. (273 aa)
AND_005246Uncharacterized protein. (490 aa)
AND_005056Cyclin a; Belongs to the cyclin family. (488 aa)
AND_004468Rothmund-thomson syndrome DNA helicase recq4. (1671 aa)
AND_002618Cell cycle checkpoint protein rad17. (458 aa)
AND_003844Aspartyl-tRNA synthetase. (553 aa)
AND_002533Crossover junction endonuclease MUS81. (462 aa)
AND_000682Uncharacterized protein. (474 aa)
AND_001696Cdk1; Belongs to the protein kinase superfamily. (339 aa)
AND_001203DUF1767 domain-containing protein. (659 aa)
AND_000205Uncharacterized protein. (2126 aa)
AND_000781Uncharacterized protein. (209 aa)
AND_009204Ubiquitin. (77 aa)
AND_008837FHA domain-containing protein. (720 aa)
AND_007036Uncharacterized protein. (1276 aa)
AND_007799Uncharacterized protein. (1207 aa)
AND_006224DNA repair protein RAD50. (1309 aa)
AND_007997Timeout/timeless-2. (1181 aa)
AND_008542Uncharacterized protein. (879 aa)
AND_008265EGF-like domain-containing protein. (272 aa)
AND_008137Serine/threonine-protein phosphatase. (273 aa)
AND_006316Uncharacterized protein. (815 aa)
AND_006536Ubiquitin. (78 aa)
AND_005572Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (621 aa)
AND_006534Ubiquitin-5E. (154 aa)
AND_006315ANK_REP_REGION domain-containing protein. (220 aa)
AND_006487Cuticular protein 122, RR-2 family. (139 aa)
AND_0099093-5 exonuclease. (787 aa)
AND_010064Timeless protein. (1288 aa)
AND_009880DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (339 aa)
AND_009248Uncharacterized protein. (882 aa)
AND_009395RING-type domain-containing protein. (707 aa)
AND_008496Chromatin regulatory protein sir2. (353 aa)
AND_009917Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (458 aa)
AND_009916DNA topoisomerase 2-binding protein 1. (653 aa)
Your Current Organism:
Anopheles darlingi
NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi
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