(38 nodes) DNA Damage Bypass network (Anopheles darlingi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_008613	Replication factor C subunit 4. (360 aa)
	AND_000232	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family. (1185 aa)
	AND_009233	DNA polymerase zeta catalytic subunit. (2136 aa)
	AND_008701	Uncharacterized protein. (483 aa)
	AND_008761	Lethal(2)denticleless. (860 aa)
	AND_009390	Replication factor C subunit 1. (1023 aa)
	AND_009416	Ubiquitin fusion degradation protein 1. (305 aa)
	AND_009962	AFG2. (791 aa)
	AND_006215	Ubiquitin/60S ribosomal protein L40 fusion. (128 aa)
	AND_000781	Uncharacterized protein. (209 aa)
	AND_000205	Uncharacterized protein. (2126 aa)
	AND_001925	WD repeat-containing protein 48. (725 aa)
	AND_001637	DNA polymerase epsilon subunit 3. (127 aa)
	AND_000839	Replication factor C subunit 3. (358 aa)
	AND_000893	USP domain-containing protein; Belongs to the peptidase C19 family. (1056 aa)
	AND_004464	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	AND_004056	DNA polymerase eta. (876 aa)
	AND_003245	RING-type domain-containing protein. (184 aa)
	AND_004268	DNA repair protein xp-e. (1139 aa)
	AND_004853	RanBP2-type domain-containing protein. (872 aa)
	AND_003988	KxDL domain-containing protein. (247 aa)
	AND_005988	Spermatogenesis associated factor; Belongs to the AAA ATPase family. (806 aa)
	AND_002281	Replication factor C subunit 2. (343 aa)
	AND_000682	Uncharacterized protein. (474 aa)
	AND_000920	Insect replication protein a. (245 aa)
	AND_004753	Uncharacterized protein. (781 aa)
	AND_004866	Nuclear protein localization. (470 aa)
	AND_006708	Cullin; Belongs to the cullin family. (759 aa)
	AND_006534	Ubiquitin-5E. (154 aa)
	AND_005572	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (621 aa)
	AND_006441	Replication factor c / DNA polymerase iii gamma-tau subunit. (327 aa)
	AND_007748	USP domain-containing protein; Belongs to the peptidase C19 family. (2304 aa)
	AND_006536	Ubiquitin. (78 aa)
	AND_007811	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2234 aa)
	AND_006402	Vitellogenin. (471 aa)
	AND_007813	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (524 aa)
	AND_009204	Ubiquitin. (77 aa)
	AND_009749	Rev7. (208 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000205	AND_000781	W5JWG4	W5JWM6	Uncharacterized protein.	Uncharacterized protein.	0.511
AND_000205	AND_006215	W5JWG4	B6DDR1	Uncharacterized protein.	Ubiquitin/60S ribosomal protein L40 fusion.	0.500
AND_000205	AND_006534	W5JWG4	W5JEN8	Uncharacterized protein.	Ubiquitin-5E.	0.524
AND_000205	AND_006536	W5JWG4	W5JCI8	Uncharacterized protein.	Ubiquitin.	0.511
AND_000205	AND_009204	W5JWG4	W5J8K3	Uncharacterized protein.	Ubiquitin.	0.500
AND_000232	AND_000781	W5JX92	W5JWM6	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.657
AND_000232	AND_000839	W5JX92	W5JT91	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Replication factor C subunit 3.	0.591
AND_000232	AND_000920	W5JX92	W5JT14	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Insect replication protein a.	0.572
AND_000232	AND_002281	W5JX92	W5JRP3	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Replication factor C subunit 2.	0.592
AND_000232	AND_004056	W5JX92	W5JMQ9	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	DNA polymerase eta.	0.587
AND_000232	AND_004464	W5JX92	W5JM12	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.696
AND_000232	AND_006215	W5JX92	B6DDR1	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Ubiquitin/60S ribosomal protein L40 fusion.	0.667
AND_000232	AND_006441	W5JX92	W5JCV6	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Replication factor c / DNA polymerase iii gamma-tau subunit.	0.599
AND_000232	AND_006534	W5JX92	W5JEN8	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Ubiquitin-5E.	0.823
AND_000232	AND_006536	W5JX92	W5JCI8	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Ubiquitin.	0.657
AND_000232	AND_007748	W5JX92	W5JCL8	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.681
AND_000232	AND_007811	W5JX92	W5JCE7	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.497
AND_000232	AND_007813	W5JX92	W5J996	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.457
AND_000232	AND_008613	W5JX92	W5J729	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Replication factor C subunit 4.	0.591
AND_000232	AND_009204	W5JX92	W5J8K3	Ubiquitin carboxyl-terminal hydrolase 43; Belongs to the peptidase C19 family.	Ubiquitin.	0.667