(42 nodes) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 network (Anopheles darlingi)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AND_009204	Ubiquitin. (77 aa)
	AND_000667	26S proteasome non-ATPase regulatory subunit 10. (260 aa)
	AND_000045	26S protease regulatory subunit; Belongs to the AAA ATPase family. (403 aa)
	AND_001949	PI31_Prot_N domain-containing protein. (256 aa)
	AND_001623	Putative 26s proteasome non-atpase regulatory subunit 8. (262 aa)
	AND_003245	RING-type domain-containing protein. (184 aa)
	AND_003255	Proteasome subunit. (312 aa)
	AND_002229	26S proteasome non-ATPase regulatory subunit 4. (411 aa)
	AND_003950	Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
	AND_002522	26S proteasome regulatory subunit 7, psd7. (338 aa)
	AND_002536	Proteasome subunit beta. (205 aa)
	AND_003221	26S proteasome non-ATPase regulatory subunit 13. (380 aa)
	AND_004067	26S protease regulatory subunit S10B; Belongs to the AAA ATPase family. (392 aa)
	AND_004101	Glycogen synthase kinase 3 beta. (1092 aa)
	AND_004877	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
	AND_004298	Uncharacterized protein. (494 aa)
	AND_004448	Proteasome subunit beta. (287 aa)
	AND_005485	Cap-n-collar. (437 aa)
	AND_005862	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	AND_005491	Segmentation protein cap'n'collar. (695 aa)
	AND_004872	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
	AND_006319	Proteasome regulatory subunit. (462 aa)
	AND_006534	Ubiquitin-5E. (154 aa)
	AND_005559	Proteasome subunit beta. (205 aa)
	AND_006583	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (241 aa)
	AND_006108	Putative 26s protease regulatory subunit 6a; Belongs to the AAA ATPase family. (429 aa)
	AND_007608	26S proteasome regulatory subunit S3. (495 aa)
	AND_008478	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (899 aa)
	AND_008203	Proteasome subunit beta. (229 aa)
	AND_008899	Proteasome subunit beta type. (231 aa)
	AND_009038	26S protease regulatory subunit; Belongs to the AAA ATPase family. (435 aa)
	AND_007674	26S proteasome subunit S9. (416 aa)
	AND_009479	Cullin; Belongs to the cullin family. (778 aa)
	AND_008370	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1051 aa)
	AND_008431	Putative 26s proteasome regulatory complex subunit rpn11. (311 aa)
	AND_009726	26S proteasome non-ATPase regulatory subunit 6. (389 aa)
	AND_009504	Skp1; Belongs to the SKP1 family. (162 aa)
	AND_010533	Proteasome subunit beta. (279 aa)
	AND_010165	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	AND_009925	Putative 26s protease regulatory subunit 6b; Belongs to the AAA ATPase family. (412 aa)
	AND_008850	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (438 aa)
	AND_006215	Ubiquitin/60S ribosomal protein L40 fusion. (128 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000045	AND_000667	W5JVB2	W5JWD6	26S protease regulatory subunit; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 10.	0.997
AND_000045	AND_001623	W5JVB2	W5JTH7	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Putative 26s proteasome non-atpase regulatory subunit 8.	0.999
AND_000045	AND_001949	W5JVB2	W5JTN2	26S protease regulatory subunit; Belongs to the AAA ATPase family.	PI31_Prot_N domain-containing protein.	0.704
AND_000045	AND_002229	W5JVB2	W5JNN9	26S protease regulatory subunit; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 4.	0.999
AND_000045	AND_002522	W5JVB2	W5JMV0	26S protease regulatory subunit; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit 7, psd7.	0.999
AND_000045	AND_002536	W5JVB2	W5JMT3	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.999
AND_000045	AND_003221	W5JVB2	W5JLM8	26S protease regulatory subunit; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 13.	0.999
AND_000045	AND_003245	W5JVB2	W5JQ39	26S protease regulatory subunit; Belongs to the AAA ATPase family.	RING-type domain-containing protein.	0.700
AND_000045	AND_003255	W5JVB2	W5JQ25	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit.	0.801
AND_000045	AND_003950	W5JVB2	W5JN42	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.998
AND_000045	AND_004067	W5JVB2	W5JLL0	26S protease regulatory subunit; Belongs to the AAA ATPase family.	26S protease regulatory subunit S10B; Belongs to the AAA ATPase family.	0.999
AND_000045	AND_004298	W5JVB2	W5JKZ2	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.987
AND_000045	AND_004448	W5JVB2	W5JKI9	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.997
AND_000045	AND_004872	W5JVB2	W5JH83	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.998
AND_000045	AND_004877	W5JVB2	W5JL01	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
AND_000045	AND_005485	W5JVB2	W5JJ44	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Cap-n-collar.	0.628
AND_000045	AND_005491	W5JVB2	W5JHN0	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Segmentation protein cap'n'collar.	0.628
AND_000045	AND_005559	W5JVB2	W5JEL5	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.998
AND_000045	AND_005862	W5JVB2	W5JI52	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.995
AND_000045	AND_006108	W5JVB2	W5JDN7	26S protease regulatory subunit; Belongs to the AAA ATPase family.	Putative 26s protease regulatory subunit 6a; Belongs to the AAA ATPase family.	0.999