(6 nodes) Extrinsic Pathway of Fibrin Clot Formation, and Blood coagulation, common pathway network (Ictidomys tridecemlineatus)

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Your Input:
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (293 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	F9	Coagulation factor IX. (463 aa)
	SERPINC1	Serpin family C member 1; Belongs to the serpin family. (465 aa)
	F10	Coagulation factor X. (483 aa)
	F7	Coagulation factor VII; Belongs to the peptidase S1 family. (375 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F10	F2	ENSSTOP00000020517	ENSSTOP00000004608	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.992
F10	F3	ENSSTOP00000020517	ENSSTOP00000004097	Coagulation factor X.	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	0.965
F10	F7	ENSSTOP00000020517	ENSSTOP00000021387	Coagulation factor X.	Coagulation factor VII; Belongs to the peptidase S1 family.	0.952
F10	F9	ENSSTOP00000020517	ENSSTOP00000009692	Coagulation factor X.	Coagulation factor IX.	0.879
F10	SERPINC1	ENSSTOP00000020517	ENSSTOP00000014347	Coagulation factor X.	Serpin family C member 1; Belongs to the serpin family.	0.993
F2	F10	ENSSTOP00000004608	ENSSTOP00000020517	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.992
F2	F3	ENSSTOP00000004608	ENSSTOP00000004097	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	0.779
F2	F7	ENSSTOP00000004608	ENSSTOP00000021387	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VII; Belongs to the peptidase S1 family.	0.922
F2	F9	ENSSTOP00000004608	ENSSTOP00000009692	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.927
F2	SERPINC1	ENSSTOP00000004608	ENSSTOP00000014347	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family C member 1; Belongs to the serpin family.	0.999
F3	F10	ENSSTOP00000004097	ENSSTOP00000020517	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Coagulation factor X.	0.965
F3	F2	ENSSTOP00000004097	ENSSTOP00000004608	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.779
F3	F7	ENSSTOP00000004097	ENSSTOP00000021387	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Coagulation factor VII; Belongs to the peptidase S1 family.	0.997
F3	F9	ENSSTOP00000004097	ENSSTOP00000009692	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Coagulation factor IX.	0.965
F3	SERPINC1	ENSSTOP00000004097	ENSSTOP00000014347	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Serpin family C member 1; Belongs to the serpin family.	0.654
F7	F10	ENSSTOP00000021387	ENSSTOP00000020517	Coagulation factor VII; Belongs to the peptidase S1 family.	Coagulation factor X.	0.952
F7	F2	ENSSTOP00000021387	ENSSTOP00000004608	Coagulation factor VII; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.922
F7	F3	ENSSTOP00000021387	ENSSTOP00000004097	Coagulation factor VII; Belongs to the peptidase S1 family.	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	0.997
F7	F9	ENSSTOP00000021387	ENSSTOP00000009692	Coagulation factor VII; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.851
F7	SERPINC1	ENSSTOP00000021387	ENSSTOP00000014347	Coagulation factor VII; Belongs to the peptidase S1 family.	Serpin family C member 1; Belongs to the serpin family.	0.958