(20 nodes) Clathrin coat of coated pit, and NECAP, PHear domain network (Ictidomys tridecemlineatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	AP2B1	AP complex subunit beta. (951 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1667 aa)
	ITSN2	Intersectin 2. (1655 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
	NECAP1	NECAP endocytosis associated 1. (275 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (914 aa)
	NECAP2	NECAP endocytosis associated 2. (265 aa)
	EPN3	Epsin 3. (636 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	ITSN1	Intersectin 1. (1655 aa)
	HIP1	Huntingtin interacting protein 1. (989 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (660 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1687 aa)
	EPS15L1	Epidermal growth factor receptor pathway substrate 15 like 1. (935 aa)
	EPN2	Epsin 2. (648 aa)
	AP1B1	AP complex subunit beta. (946 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	GAK	Cyclin G associated kinase. (1322 aa)
	Eps15	Uncharacterized protein. (925 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1B1	AP2A1	ENSSTOP00000026949	ENSSTOP00000024091	AP complex subunit beta.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.991
AP1B1	AP2A2	ENSSTOP00000026949	ENSSTOP00000010125	AP complex subunit beta.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.989
AP1B1	AP2B1	ENSSTOP00000026949	ENSSTOP00000001819	AP complex subunit beta.	AP complex subunit beta.	0.586
AP1B1	AP2M1	ENSSTOP00000026949	ENSSTOP00000007414	AP complex subunit beta.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.994
AP1B1	CLTA	ENSSTOP00000026949	ENSSTOP00000027247	AP complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.923
AP1B1	CLTB	ENSSTOP00000026949	ENSSTOP00000019393	AP complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.920
AP1B1	CLTC	ENSSTOP00000026949	ENSSTOP00000025586	AP complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.967
AP1B1	CLTCL1	ENSSTOP00000026949	ENSSTOP00000002551	AP complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.967
AP1B1	EPN2	ENSSTOP00000026949	ENSSTOP00000026889	AP complex subunit beta.	Epsin 2.	0.817
AP1B1	EPN3	ENSSTOP00000026949	ENSSTOP00000015568	AP complex subunit beta.	Epsin 3.	0.753
AP1B1	EPS15L1	ENSSTOP00000026949	ENSSTOP00000026298	AP complex subunit beta.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.886
AP1B1	Eps15	ENSSTOP00000026949	ENSSTOP00000030844	AP complex subunit beta.	Uncharacterized protein.	0.830
AP1B1	GAK	ENSSTOP00000026949	ENSSTOP00000030676	AP complex subunit beta.	Cyclin G associated kinase.	0.997
AP1B1	HIP1	ENSSTOP00000026949	ENSSTOP00000021846	AP complex subunit beta.	Huntingtin interacting protein 1.	0.824
AP1B1	ITSN1	ENSSTOP00000026949	ENSSTOP00000020496	AP complex subunit beta.	Intersectin 1.	0.998
AP1B1	ITSN2	ENSSTOP00000026949	ENSSTOP00000002868	AP complex subunit beta.	Intersectin 2.	0.999
AP1B1	NECAP1	ENSSTOP00000026949	ENSSTOP00000009106	AP complex subunit beta.	NECAP endocytosis associated 1.	0.896
AP1B1	NECAP2	ENSSTOP00000026949	ENSSTOP00000012278	AP complex subunit beta.	NECAP endocytosis associated 2.	0.922
AP1B1	PICALM	ENSSTOP00000026949	ENSSTOP00000024059	AP complex subunit beta.	Phosphatidylinositol binding clathrin assembly protein.	0.816
AP2A1	AP1B1	ENSSTOP00000024091	ENSSTOP00000026949	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.991