STRINGSTRING
ORMDL2 ORMDL2 LPCAT3 LPCAT3 LPCAT4 LPCAT4 ISM1 ISM1 ORMDL1 ORMDL1 PLPP5 PLPP5 SGMS1 SGMS1 SGMS2 SGMS2 LPL LPL CTDSPL CTDSPL PLCD1 PLCD1 SELENOI SELENOI NIPAL4 NIPAL4 ABHD5 ABHD5 CIDEC CIDEC UGCG UGCG ACER1 ACER1 SGPL1 SGPL1 AGPAT4 AGPAT4 ACER3 ACER3 TM9SF3 TM9SF3 UCP1 UCP1 ISM2 ISM2 SPTLC2 SPTLC2 PITPNC1 PITPNC1 PLA1A PLA1A PLD6 PLD6 SMPDL3B SMPDL3B DEGS2 DEGS2 CERS3 CERS3 LINS1 LINS1 LCLAT1 LCLAT1 GPD1 GPD1 CERS5 CERS5 ARHGEF39 ARHGEF39 PITPNA PITPNA GBA2 GBA2 RMDN1 RMDN1 ABHD2 ABHD2 ORMDL3 ORMDL3 PCYT2 PCYT2 CDS2 CDS2 CERS2 CERS2 PLPP4 PLPP4 GPAT2 GPAT2 PSAP PSAP KDSR KDSR LIPF LIPF LIPK LIPK LIPN LIPN PTDSS1 PTDSS1 DGKK DGKK ETNK1 ETNK1 AGPAT1 AGPAT1 MBOAT1 MBOAT1 CTDSP1 CTDSP1 GBA GBA SMPD1 SMPD1 CDS1 CDS1 CERKL CERKL DGKH DGKH PLD1 PLD1 PITPNM2 PITPNM2 AGPAT3 AGPAT3 TMEM130 TMEM130 LPIN1 LPIN1 PGS1 PGS1 PLCZ1 PLCZ1 SGPP1 SGPP1 DGKD DGKD CHKA CHKA Lipe Lipe CHPT1 CHPT1 MOGAT2 MOGAT2 DGAT2 DGAT2 SPHK2 SPHK2 SPTLC1 SPTLC1 GPAT4 GPAT4 PISD PISD SMPD3 SMPD3 ENPP7 ENPP7 PITPNB PITPNB PNPLA3 PNPLA3 HDHD5 HDHD5 DGKQ DGKQ PLD2 PLD2 PCYT1B PCYT1B ETNK2 ETNK2 ASAH1 ASAH1 Crls1 Crls1 LIPG LIPG ADIPOQ ADIPOQ FASTK FASTK SGPP2 SGPP2 MOGAT1 MOGAT1 SAMD8 SAMD8 MN1 MN1 ASPRV1 ASPRV1 SPTLC3 SPTLC3 ASAH2 ASAH2 CERS6 CERS6 Chkb Chkb RMDN3 RMDN3 PLPP2 PLPP2 RETN RETN LPIN3 LPIN3 CFD CFD SLC2A12 SLC2A12 PLIN1 PLIN1 Smpd5 Smpd5 PHOSPHO1 PHOSPHO1 G0S2 G0S2 PLD4 PLD4 ACER2 ACER2 SMPD4 SMPD4 SPTSSA SPTSSA GPAT3 GPAT3 Rmdn2 Rmdn2 PNPLA5 PNPLA5 CERS4 CERS4 GALC GALC PLIN3 PLIN3 MOGAT3 MOGAT3 SPTSSB SPTSSB PTDSS2 PTDSS2 PLIN5 PLIN5 SPHK1 SPHK1 CERK CERK LPGAT1 LPGAT1 CTDSP2 CTDSP2 Plpp3 Plpp3 CTDNEP1 CTDNEP1 DGAT2L6 DGAT2L6 Degs1 Degs1 MBOAT7 MBOAT7 Cers1 Cers1 AGPAT2 AGPAT2 PNPLA1 PNPLA1 DGAT1 DGAT1 AGPAT5 AGPAT5 LPCAT1 LPCAT1 TAZ TAZ ABHD4 ABHD4 LPIN2 LPIN2 PLPP1 PLPP1 ENSSTOP00000025453 ENSSTOP00000025453 LIPM LIPM CEPT1 CEPT1 ENSSTOP00000025506 ENSSTOP00000025506 PNPLA2 PNPLA2 PLD3 PLD3 ADIG ADIG DGKG DGKG PLD5 PLD5 PEMT PEMT CIDEA CIDEA ETNPPL ETNPPL PITPNM3 PITPNM3 LYPLA1 LYPLA1 SMPD2 SMPD2 PCYT1A PCYT1A MBOAT2 MBOAT2 ENSSTOP00000029929 ENSSTOP00000029929 DGKB DGKB CDIPT CDIPT LIPC LIPC DGKA DGKA DGKZ DGKZ GPAM GPAM LOC101978286 LOC101978286 CNEP1R1 CNEP1R1 PLIN2 PLIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
LPCAT4Lysophosphatidylcholine acyltransferase 4. (508 aa)
ISM1Isthmin 1. (464 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
PLPP5Phospholipid phosphatase 5. (263 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (473 aa)
CTDSPLCTD small phosphatase like. (272 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
SELENOISelenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (386 aa)
NIPAL4NIPA like domain containing 4. (394 aa)
ABHD5Abhydrolase domain containing 5. (349 aa)
CIDECCell death inducing DFFA like effector c. (252 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (268 aa)
TM9SF3Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (555 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
ISM2Isthmin 2. (437 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (549 aa)
PITPNC1Phosphatidylinositol transfer protein cytoplasmic 1. (309 aa)
PLA1APhospholipase A1 member A. (456 aa)
PLD6Phospholipase D family member 6. (222 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (456 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
CERS3Ceramide synthase 3. (383 aa)
LINS1Lines homolog 1. (762 aa)
LCLAT1Lysocardiolipin acyltransferase 1. (376 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
CERS5Ceramide synthase 5. (392 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
PITPNAPhosphatidylinositol transfer protein alpha. (270 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (919 aa)
RMDN1Regulator of microtubule dynamics 1. (305 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
PCYT2Phosphate cytidylyltransferase 2, ethanolamine. (404 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
CERS2Ceramide synthase 2. (380 aa)
PLPP4Phospholipid phosphatase 4. (271 aa)
GPAT2Glycerol-3-phosphate acyltransferase 2, mitochondrial. (801 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (551 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
LIPFLipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
LIPKLipase; Belongs to the AB hydrolase superfamily. Lipase family. (404 aa)
LIPNLipase; Belongs to the AB hydrolase superfamily. Lipase family. (419 aa)
PTDSS1Phosphatidylserine synthase 1. (473 aa)
DGKKDiacylglycerol kinase. (1110 aa)
ETNK1Ethanolamine kinase 1. (363 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
MBOAT1Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. (417 aa)
CTDSP1CTD small phosphatase 1. (238 aa)
GBAGlucosylceramidase. (516 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
CERKLCeramide kinase like. (540 aa)
DGKHDiacylglycerol kinase. (1216 aa)
PLD1Phospholipase. (1037 aa)
PITPNM2Phosphatidylinositol transfer protein membrane associated 2. (1330 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
TMEM130Transmembrane protein 130. (338 aa)
LPIN1Lipin 1. (930 aa)
PGS1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (508 aa)
PLCZ1Phosphoinositide phospholipase C. (594 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (428 aa)
DGKDDiacylglycerol kinase. (1170 aa)
CHKACholine kinase alpha. (411 aa)
LipeHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (371 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (334 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
SPHK2Sphingosine kinase 2. (655 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (427 aa)
PITPNBPhosphatidylinositol transfer protein beta. (272 aa)
PNPLA3Patatin like phospholipase domain containing 3. (420 aa)
HDHD5Haloacid dehalogenase like hydrolase domain containing 5. (394 aa)
DGKQDiacylglycerol kinase. (924 aa)
PLD2Phospholipase. (933 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
ETNK2Ethanolamine kinase 2. (386 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
Crls1Uncharacterized protein. (302 aa)
LIPGLipase G, endothelial type. (500 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
FASTKFas activated serine/threonine kinase. (549 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (399 aa)
MOGAT1Monoacylglycerol O-acyltransferase 1. (335 aa)
SAMD8Sterile alpha motif domain containing 8. (478 aa)
MN1MN1 proto-oncogene, transcriptional regulator. (1028 aa)
ASPRV1Aspartic peptidase retroviral like 1. (334 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
ASAH2Neutral ceramidase. (716 aa)
CERS6Ceramide synthase 6. (392 aa)
ChkbCholine kinase beta. (402 aa)
RMDN3Regulator of microtubule dynamics 3. (472 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
RETNResistin. (109 aa)
LPIN3Lipin 3. (841 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (258 aa)
SLC2A12Solute carrier family 2 member 12; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (621 aa)
PLIN1Perilipin; Belongs to the perilipin family. (517 aa)
Smpd5Endo/exonuclease/phosphatase domain-containing protein. (472 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
G0S2G0/G1 switch 2. (105 aa)
PLD4Phospholipase D family member 4. (505 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (827 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (370 aa)
Rmdn2Uncharacterized protein. (425 aa)
PNPLA5Patatin like phospholipase domain containing 5. (389 aa)
CERS4Ceramide synthase 4. (481 aa)
GALCGalactosylceramidase. (622 aa)
PLIN3Perilipin; Belongs to the perilipin family. (465 aa)
MOGAT3Monoacylglycerol O-acyltransferase 3. (343 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (76 aa)
PTDSS2Phosphatidylserine synthase 2. (455 aa)
PLIN5Perilipin; Belongs to the perilipin family. (448 aa)
SPHK1Sphingosine kinase 1. (385 aa)
CERKCeramide kinase. (461 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
CTDSP2CTD small phosphatase 2. (271 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (243 aa)
DGAT2L6Diacylglycerol O-acyltransferase 2 like 6. (337 aa)
Degs1FA_desaturase domain-containing protein. (389 aa)
MBOAT7Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (472 aa)
Cers1TLC domain-containing protein. (350 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (218 aa)
PNPLA1Patatin like phospholipase domain containing 1. (515 aa)
DGAT1O-acyltransferase. (500 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (213 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (522 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
ABHD4Abhydrolase domain containing 4. (355 aa)
LPIN2Lipin 2. (866 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
ENSSTOP00000025453Lipid_DES domain-containing protein. (273 aa)
LIPMLipase; Belongs to the AB hydrolase superfamily. Lipase family. (425 aa)
CEPT1Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (416 aa)
ENSSTOP00000025506Uncharacterized protein. (178 aa)
PNPLA2Patatin like phospholipase domain containing 2. (489 aa)
PLD3Phospholipase D family member 3. (520 aa)
ADIGAdipogenin. (87 aa)
DGKGDiacylglycerol kinase. (791 aa)
PLD5Phospholipase D family member 5. (510 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (225 aa)
CIDEACell death inducing DFFA like effector a. (171 aa)
ETNPPLEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa)
PITPNM3PITPNM family member 3. (973 aa)
LYPLA1Lysophospholipase 1. (230 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (419 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (367 aa)
MBOAT2Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family. (495 aa)
ENSSTOP00000029929Uncharacterized protein. (162 aa)
DGKBDiacylglycerol kinase. (802 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (134 aa)
LIPCLipase C, hepatic type. (463 aa)
DGKADiacylglycerol kinase. (799 aa)
DGKZDiacylglycerol kinase. (1154 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (827 aa)
LOC101978286Uncharacterized protein. (455 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
PLIN2Perilipin; Belongs to the perilipin family. (443 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (14%) [HD]