(5 nodes) NEDD8 activating enzyme activity, and Protein neddylation network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBA3	Ubiquitin like modifier activating enzyme 3. (450 aa)
	SENP8	SUMO peptidase family member, NEDD8 specific. (231 aa)
	NEDD8	NEDD8 ubiquitin like modifier. (81 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (538 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NAE1	NEDD8	ENSSTOP00000020190	ENSSTOP00000020023	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	NEDD8 ubiquitin like modifier.	0.992
NAE1	SENP8	ENSSTOP00000020190	ENSSTOP00000011344	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	SUMO peptidase family member, NEDD8 specific.	0.868
NAE1	UBA3	ENSSTOP00000020190	ENSSTOP00000002872	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin like modifier activating enzyme 3.	0.999
NAE1	UBE2M	ENSSTOP00000020190	ENSSTOP00000022397	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.987
NEDD8	NAE1	ENSSTOP00000020023	ENSSTOP00000020190	NEDD8 ubiquitin like modifier.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.992
NEDD8	SENP8	ENSSTOP00000020023	ENSSTOP00000011344	NEDD8 ubiquitin like modifier.	SUMO peptidase family member, NEDD8 specific.	0.999
NEDD8	UBA3	ENSSTOP00000020023	ENSSTOP00000002872	NEDD8 ubiquitin like modifier.	Ubiquitin like modifier activating enzyme 3.	0.999
NEDD8	UBE2M	ENSSTOP00000020023	ENSSTOP00000022397	NEDD8 ubiquitin like modifier.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.997
SENP8	NAE1	ENSSTOP00000011344	ENSSTOP00000020190	SUMO peptidase family member, NEDD8 specific.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.868
SENP8	NEDD8	ENSSTOP00000011344	ENSSTOP00000020023	SUMO peptidase family member, NEDD8 specific.	NEDD8 ubiquitin like modifier.	0.999
SENP8	UBA3	ENSSTOP00000011344	ENSSTOP00000002872	SUMO peptidase family member, NEDD8 specific.	Ubiquitin like modifier activating enzyme 3.	0.894
SENP8	UBE2M	ENSSTOP00000011344	ENSSTOP00000022397	SUMO peptidase family member, NEDD8 specific.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.518
UBA3	NAE1	ENSSTOP00000002872	ENSSTOP00000020190	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.999
UBA3	NEDD8	ENSSTOP00000002872	ENSSTOP00000020023	Ubiquitin like modifier activating enzyme 3.	NEDD8 ubiquitin like modifier.	0.999
UBA3	SENP8	ENSSTOP00000002872	ENSSTOP00000011344	Ubiquitin like modifier activating enzyme 3.	SUMO peptidase family member, NEDD8 specific.	0.894
UBA3	UBE2M	ENSSTOP00000002872	ENSSTOP00000022397	Ubiquitin like modifier activating enzyme 3.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.991
UBE2M	NAE1	ENSSTOP00000022397	ENSSTOP00000020190	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.987
UBE2M	NEDD8	ENSSTOP00000022397	ENSSTOP00000020023	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	NEDD8 ubiquitin like modifier.	0.997
UBE2M	SENP8	ENSSTOP00000022397	ENSSTOP00000011344	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	SUMO peptidase family member, NEDD8 specific.	0.518
UBE2M	UBA3	ENSSTOP00000022397	ENSSTOP00000002872	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin like modifier activating enzyme 3.	0.991