(17 nodes) Tissue factor, and Regulation of IFNA/IFNB signaling network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	IFNGR2	Interferon gamma receptor 2. (306 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (334 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (565 aa)
	TYK2	Tyrosine-protein kinase. (1194 aa)
	IL10	Interleukin 10. (178 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (576 aa)
	TP53BP2	Tumor protein p53 binding protein 2. (1134 aa)
	IL22	Interleukin 22. (179 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (490 aa)
	IFNGR1	Interferon gamma receptor 1. (476 aa)
	JAK1	Tyrosine-protein kinase. (1142 aa)
	LOC101968765	Uncharacterized protein. (187 aa)
	Ifnk	Uncharacterized protein. (241 aa)
	IFNLR1	Interferon lambda receptor 1. (530 aa)
	ENSSTOP00000028887	Uncharacterized protein. (184 aa)
	Ifnar2	Uncharacterized protein. (516 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSTOP00000028887	IFNAR1	ENSSTOP00000028887	ENSSTOP00000013438	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.887
ENSSTOP00000028887	IFNG	ENSSTOP00000028887	ENSSTOP00000013397	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.840
ENSSTOP00000028887	IFNGR1	ENSSTOP00000028887	ENSSTOP00000017257	Uncharacterized protein.	Interferon gamma receptor 1.	0.844
ENSSTOP00000028887	IFNGR2	ENSSTOP00000028887	ENSSTOP00000000477	Uncharacterized protein.	Interferon gamma receptor 2.	0.805
ENSSTOP00000028887	IFNLR1	ENSSTOP00000028887	ENSSTOP00000021517	Uncharacterized protein.	Interferon lambda receptor 1.	0.841
ENSSTOP00000028887	IL10RA	ENSSTOP00000028887	ENSSTOP00000007020	Uncharacterized protein.	Interleukin 10 receptor subunit alpha.	0.785
ENSSTOP00000028887	IL10RB	ENSSTOP00000028887	ENSSTOP00000001140	Uncharacterized protein.	Interleukin 10 receptor subunit beta.	0.777
ENSSTOP00000028887	IL22RA1	ENSSTOP00000028887	ENSSTOP00000001350	Uncharacterized protein.	Interleukin 22 receptor subunit alpha 1.	0.785
ENSSTOP00000028887	Ifnar2	ENSSTOP00000028887	ENSSTOP00000031600	Uncharacterized protein.	Uncharacterized protein.	0.882
ENSSTOP00000028887	JAK1	ENSSTOP00000028887	ENSSTOP00000019944	Uncharacterized protein.	Tyrosine-protein kinase.	0.811
ENSSTOP00000028887	LOC101968765	ENSSTOP00000028887	ENSSTOP00000020234	Uncharacterized protein.	Uncharacterized protein.	0.825
ENSSTOP00000028887	TP53BP2	ENSSTOP00000028887	ENSSTOP00000008436	Uncharacterized protein.	Tumor protein p53 binding protein 2.	0.777
ENSSTOP00000028887	TYK2	ENSSTOP00000028887	ENSSTOP00000002949	Uncharacterized protein.	Tyrosine-protein kinase.	0.645
IFNAR1	ENSSTOP00000028887	ENSSTOP00000013438	ENSSTOP00000028887	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.887
IFNAR1	IFNG	ENSSTOP00000013438	ENSSTOP00000013397	Interferon alpha and beta receptor subunit 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.938
IFNAR1	IFNGR1	ENSSTOP00000013438	ENSSTOP00000017257	Interferon alpha and beta receptor subunit 1.	Interferon gamma receptor 1.	0.960
IFNAR1	IFNGR2	ENSSTOP00000013438	ENSSTOP00000000477	Interferon alpha and beta receptor subunit 1.	Interferon gamma receptor 2.	0.905
IFNAR1	IFNLR1	ENSSTOP00000013438	ENSSTOP00000021517	Interferon alpha and beta receptor subunit 1.	Interferon lambda receptor 1.	0.971
IFNAR1	IL10	ENSSTOP00000013438	ENSSTOP00000005716	Interferon alpha and beta receptor subunit 1.	Interleukin 10.	0.969
IFNAR1	IL10RA	ENSSTOP00000013438	ENSSTOP00000007020	Interferon alpha and beta receptor subunit 1.	Interleukin 10 receptor subunit alpha.	0.940