(7 nodes) Insulin-like growth factor-binding protein family 1-6, chordata, and Pappalysin-1/2 network (Ictidomys tridecemlineatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IGFBP1	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). (272 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (293 aa)
	IGFBP6	Insulin like growth factor binding protein 6. (235 aa)
	IGFALS	Insulin like growth factor binding protein acid labile subunit. (604 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (271 aa)
	IGFBP4	Insulin like growth factor binding protein 4. (258 aa)
	PAPPA2	Pappalysin 2. (1787 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IGFALS	IGFBP1	ENSSTOP00000016748	ENSSTOP00000007832	Insulin like growth factor binding protein acid labile subunit.	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	0.525
IGFALS	IGFBP3	ENSSTOP00000016748	ENSSTOP00000007843	Insulin like growth factor binding protein acid labile subunit.	Insulin like growth factor binding protein 3.	0.992
IGFALS	IGFBP5	ENSSTOP00000016748	ENSSTOP00000017426	Insulin like growth factor binding protein acid labile subunit.	Insulin like growth factor binding protein 5.	0.925
IGFALS	IGFBP6	ENSSTOP00000016748	ENSSTOP00000009883	Insulin like growth factor binding protein acid labile subunit.	Insulin like growth factor binding protein 6.	0.578
IGFBP1	IGFALS	ENSSTOP00000007832	ENSSTOP00000016748	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	Insulin like growth factor binding protein acid labile subunit.	0.525
IGFBP1	IGFBP3	ENSSTOP00000007832	ENSSTOP00000007843	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	Insulin like growth factor binding protein 3.	0.505
IGFBP1	IGFBP4	ENSSTOP00000007832	ENSSTOP00000019610	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	Insulin like growth factor binding protein 4.	0.944
IGFBP1	IGFBP6	ENSSTOP00000007832	ENSSTOP00000009883	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	Insulin like growth factor binding protein 6.	0.556
IGFBP3	IGFALS	ENSSTOP00000007843	ENSSTOP00000016748	Insulin like growth factor binding protein 3.	Insulin like growth factor binding protein acid labile subunit.	0.992
IGFBP3	IGFBP1	ENSSTOP00000007843	ENSSTOP00000007832	Insulin like growth factor binding protein 3.	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	0.505
IGFBP3	IGFBP4	ENSSTOP00000007843	ENSSTOP00000019610	Insulin like growth factor binding protein 3.	Insulin like growth factor binding protein 4.	0.780
IGFBP3	IGFBP5	ENSSTOP00000007843	ENSSTOP00000017426	Insulin like growth factor binding protein 3.	Insulin like growth factor binding protein 5.	0.725
IGFBP3	IGFBP6	ENSSTOP00000007843	ENSSTOP00000009883	Insulin like growth factor binding protein 3.	Insulin like growth factor binding protein 6.	0.426
IGFBP4	IGFBP1	ENSSTOP00000019610	ENSSTOP00000007832	Insulin like growth factor binding protein 4.	Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).	0.944
IGFBP4	IGFBP3	ENSSTOP00000019610	ENSSTOP00000007843	Insulin like growth factor binding protein 4.	Insulin like growth factor binding protein 3.	0.780
IGFBP4	IGFBP5	ENSSTOP00000019610	ENSSTOP00000017426	Insulin like growth factor binding protein 4.	Insulin like growth factor binding protein 5.	0.625
IGFBP4	IGFBP6	ENSSTOP00000019610	ENSSTOP00000009883	Insulin like growth factor binding protein 4.	Insulin like growth factor binding protein 6.	0.625
IGFBP4	PAPPA2	ENSSTOP00000019610	ENSSTOP00000032524	Insulin like growth factor binding protein 4.	Pappalysin 2.	0.506
IGFBP5	IGFALS	ENSSTOP00000017426	ENSSTOP00000016748	Insulin like growth factor binding protein 5.	Insulin like growth factor binding protein acid labile subunit.	0.925
IGFBP5	IGFBP3	ENSSTOP00000017426	ENSSTOP00000007843	Insulin like growth factor binding protein 5.	Insulin like growth factor binding protein 3.	0.725