(57 nodes) Mixed, incl. Antiviral mechanism by IFN-stimulated genes, and Positive regulation of interferon-beta production network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRIM40	Tripartite motif containing 40. (249 aa)
	OAS3	2'-5'-oligoadenylate synthetase 3. (991 aa)
	IRF5	Interferon regulatory factor 5. (500 aa)
	IFIH1	Interferon induced with helicase C domain 1. (974 aa)
	ZC3HAV1	Zinc finger CCCH-type containing, antiviral 1. (800 aa)
	IRF7	Interferon regulatory factor 7. (472 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (361 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	SERINC4	Serine incorporator 4. (519 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	ZSCAN25	Zinc finger and SCAN domain containing 25. (556 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2 alpha kinase 1. (623 aa)
	TRIM25	Tripartite motif containing 25. (644 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (637 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
	Rtp4	Uncharacterized protein. (58 aa)
	IFIT3	Interferon induced protein with tetratricopeptide repeats 3. (487 aa)
	TRIM47	Tripartite motif containing 47. (544 aa)
	TRIM65	Tripartite motif containing 65. (443 aa)
	PARP9	Poly(ADP-ribose) polymerase family member 9. (820 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (715 aa)
	IFI44	Interferon induced protein 44. (434 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
	ADAR	Adenosine deaminase RNA specific. (1165 aa)
	I3MMH2_ICTTR	B box-type domain-containing protein. (150 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
	HERC6	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. (888 aa)
	I3MQC5_ICTTR	HECT domain-containing protein. (387 aa)
	TRIM38	Tripartite motif containing 38. (475 aa)
	TRIM14	Tripartite motif containing 14. (445 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1698 aa)
	SAMD9L	Sterile alpha motif domain containing 9 like. (1471 aa)
	RNF135	Ring finger protein 135. (421 aa)
	I3MU64_ICTTR	HSR domain-containing protein. (116 aa)
	IFIT2	Interferon induced protein with tetratricopeptide repeats 2. (423 aa)
	TRIM32	Tripartite motif containing 32. (658 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (393 aa)
	LOC101959549	Uncharacterized protein. (469 aa)
	IFIT5	Interferon induced protein with tetratricopeptide repeats 5. (482 aa)
	STING1	Transmembrane protein 173. (379 aa)
	TRIM56	Tripartite motif containing 56. (726 aa)
	IRF3	Interferon regulatory factor 3. (420 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1803 aa)
	LOC101970383	Uncharacterized protein. (465 aa)
	TRIM6	Tripartite motif containing 6. (469 aa)
	LOC101970676	Uncharacterized protein. (469 aa)
	Usp18	USP domain-containing protein; Belongs to the peptidase C19 family. (354 aa)
	Rtp3	zf-3CxxC domain-containing protein. (81 aa)
	LOC101955567	Uncharacterized protein. (140 aa)
	LOC101965602	Uncharacterized protein. (424 aa)
	ENSSTOP00000026985	OAS1_C domain-containing protein. (128 aa)
	RNF213	Ring finger protein 213. (4892 aa)
	DCLK2	Doublecortin like kinase 2. (782 aa)
	Cgas	Mab-21 domain-containing protein. (305 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DCLK2	ENSSTOP00000012687	ENSSTOP00000032176	Adenosine deaminase RNA specific.	Doublecortin like kinase 2.	0.582
ADAR	DDX58	ENSSTOP00000012687	ENSSTOP00000006269	Adenosine deaminase RNA specific.	DExD/H-box helicase 58.	0.405
ADAR	EIF2AK2	ENSSTOP00000012687	ENSSTOP00000012442	Adenosine deaminase RNA specific.	Eukaryotic translation initiation factor 2 alpha kinase 2.	0.698
ADAR	IFIH1	ENSSTOP00000012687	ENSSTOP00000004468	Adenosine deaminase RNA specific.	Interferon induced with helicase C domain 1.	0.534
ADAR	IRF7	ENSSTOP00000012687	ENSSTOP00000005114	Adenosine deaminase RNA specific.	Interferon regulatory factor 7.	0.517
ADAR	OAS1	ENSSTOP00000012687	ENSSTOP00000017124	Adenosine deaminase RNA specific.	2'-5'-oligoadenylate synthetase 1.	0.443
ADAR	OAS3	ENSSTOP00000012687	ENSSTOP00000003548	Adenosine deaminase RNA specific.	2'-5'-oligoadenylate synthetase 3.	0.413
ADAR	TRIM25	ENSSTOP00000012687	ENSSTOP00000008370	Adenosine deaminase RNA specific.	Tripartite motif containing 25.	0.487
ADAR	ZNFX1	ENSSTOP00000012687	ENSSTOP00000015469	Adenosine deaminase RNA specific.	Zinc finger NFX1-type containing 1.	0.680
Cgas	DDX58	ENSSTOP00000032196	ENSSTOP00000006269	Mab-21 domain-containing protein.	DExD/H-box helicase 58.	0.546
Cgas	IFIH1	ENSSTOP00000032196	ENSSTOP00000004468	Mab-21 domain-containing protein.	Interferon induced with helicase C domain 1.	0.505
Cgas	IRF3	ENSSTOP00000032196	ENSSTOP00000018572	Mab-21 domain-containing protein.	Interferon regulatory factor 3.	0.633
Cgas	IRF7	ENSSTOP00000032196	ENSSTOP00000005114	Mab-21 domain-containing protein.	Interferon regulatory factor 7.	0.446
Cgas	STING1	ENSSTOP00000032196	ENSSTOP00000017977	Mab-21 domain-containing protein.	Transmembrane protein 173.	0.929
Cgas	TBK1	ENSSTOP00000032196	ENSSTOP00000007452	Mab-21 domain-containing protein.	TANK binding kinase 1.	0.576
DCLK2	ADAR	ENSSTOP00000032176	ENSSTOP00000012687	Doublecortin like kinase 2.	Adenosine deaminase RNA specific.	0.582
DCLK2	RNF213	ENSSTOP00000032176	ENSSTOP00000028230	Doublecortin like kinase 2.	Ring finger protein 213.	0.423
DDX58	ADAR	ENSSTOP00000006269	ENSSTOP00000012687	DExD/H-box helicase 58.	Adenosine deaminase RNA specific.	0.405
DDX58	Cgas	ENSSTOP00000006269	ENSSTOP00000032196	DExD/H-box helicase 58.	Mab-21 domain-containing protein.	0.546
DDX58	DHX58	ENSSTOP00000006269	ENSSTOP00000005836	DExD/H-box helicase 58.	DExH-box helicase 58.	0.986