STRINGSTRING
DCLRE1C DCLRE1C POLM POLM TDP1 TDP1 APTX APTX NEIL1 NEIL1 POLB POLB TOP1 TOP1 LIG3 LIG3 XRCC5 XRCC5 SLC23A3 SLC23A3 CNPPD1 CNPPD1 XRCC6 XRCC6 PRKDC PRKDC POLL POLL APLF APLF XRCC1 XRCC1 NHEJ1 NHEJ1 XRCC4 XRCC4 PAXX PAXX LIG4 LIG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCLRE1CDNA cross-link repair 1C. (689 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (618 aa)
APTXAprataxin. (334 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (306 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
LIG3DNA ligase. (1013 aa)
XRCC5X-ray repair cross complementing 5. (734 aa)
SLC23A3Solute carrier family 23 member 3. (611 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (411 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
APLFAprataxin and PNKP like factor. (519 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
NHEJ1Non-homologous end joining factor 1. (301 aa)
XRCC4X-ray repair cross complementing 4. (330 aa)
PAXXPAXX non-homologous end joining factor. (206 aa)
LIG4DNA ligase. (911 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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