STRINGSTRING
ACVRL1 ACVRL1 ACVR1B ACVR1B SMAD6 SMAD6 INHBC INHBC BMP4 BMP4 TGFB2 TGFB2 RNF111 RNF111 MSTN MSTN GDF3 GDF3 BMPR2 BMPR2 BMP5 BMP5 AMHR2 AMHR2 SMAD2 SMAD2 ACVR1 ACVR1 SMAD9 SMAD9 LOC101967701 LOC101967701 SKIL SKIL CHRD CHRD FSTL3 FSTL3 TGFB1 TGFB1 SMAD3 SMAD3 BMP10 BMP10 SMAD1 SMAD1 SMAD5 SMAD5 INHA INHA BMP7 BMP7 FST FST TGFBR1 TGFBR1 ACVR2B ACVR2B BAMBI BAMBI BMPR1B BMPR1B SMURF1 SMURF1 BMPR1A BMPR1A TGFBR3 TGFBR3 AMH AMH SMAD7 SMAD7 LOC101976737 LOC101976737 SMAD4 SMAD4 ACVR2A ACVR2A BMP6 BMP6 GDF9 GDF9 GDF6 GDF6 BMP2 BMP2 GDF7 GDF7 LTBP3 LTBP3 NOG NOG GREM2 GREM2 INHBB INHBB INHBE INHBE GREM1 GREM1 TGFB3 TGFB3 GDF2 GDF2 GDF5 GDF5 LOC101961346 LOC101961346 GDF11 GDF11 TGFBR2 TGFBR2 SMURF2 SMURF2 ZFYVE9 ZFYVE9 Inhba Inhba HJV HJV ENSSTOP00000030884 ENSSTOP00000030884 SKI SKI Bmp8b Bmp8b ACVR1C ACVR1C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
INHBCInhibin subunit beta C. (352 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RNF111Ring finger protein 111. (984 aa)
MSTNMyostatin. (376 aa)
GDF3Growth differentiation factor 3. (360 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (550 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD9Mothers against decapentaplegic homolog. (452 aa)
LOC101967701TGF_BETA_2 domain-containing protein. (397 aa)
SKILSKI like proto-oncogene. (677 aa)
CHRDChordin. (898 aa)
FSTL3Follistatin like 3. (261 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP10Bone morphogenetic protein 10. (422 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FSTFollistatin. (330 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
SMURF1E3 ubiquitin-protein ligase. (753 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
AMHAnti-Mullerian hormone. (545 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
LOC101976737FYVE-type domain-containing protein. (1544 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
GDF9Growth differentiation factor 9. (449 aa)
GDF6Growth differentiation factor 6. (460 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF7Growth differentiation factor 7. (445 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1193 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM2Gremlin. (168 aa)
INHBBInhibin subunit beta B. (336 aa)
INHBEInhibin subunit beta E. (349 aa)
GREM1Gremlin. (184 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF5Growth differentiation factor 5. (495 aa)
LOC101961346Left-right determination factor. (363 aa)
GDF11Growth differentiation factor 11. (387 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
ENSSTOP00000030884TGF_BETA_2 domain-containing protein. (272 aa)
SKISKI proto-oncogene. (730 aa)
Bmp8bTGF_BETA_2 domain-containing protein. (252 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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