STRINGSTRING
NME8 NME8 GPX1 GPX1 LCN2 LCN2 PRDX1 PRDX1 PRKAA1 PRKAA1 ENSSTOP00000024247 ENSSTOP00000024247 Rps3 Rps3 CRK CRK NFE2L2 NFE2L2 RNF112 RNF112 MAPK7 MAPK7 EDN1 EDN1 FER FER Glrx2 Glrx2 MAPK3 MAPK3 NUDT15 NUDT15 RIPK1 RIPK1 CYP1B1 CYP1B1 RIPK3 RIPK3 PRDX3 PRDX3 ATP7A ATP7A FOS FOS PPIF PPIF TRPC6 TRPC6 UCP1 UCP1 ERCC6 ERCC6 FOSL1 FOSL1 ZNF277 ZNF277 PDGFD PDGFD SOD1 SOD1 KPNA4 KPNA4 PRKCD PRKCD FABP1 FABP1 NR4A3 NR4A3 BTK BTK I3M4W8_ICTTR I3M4W8_ICTTR Hif1a Hif1a UCP3 UCP3 TRPA1 TRPA1 NOX1 NOX1 APTX APTX MB MB MAP1LC3A MAP1LC3A LOC101973389 LOC101973389 MMP9 MMP9 PLK3 PLK3 NCF1 NCF1 SLC4A1 SLC4A1 STK24 STK24 EGFR EGFR FYN FYN NET1 NET1 TNFAIP3 TNFAIP3 AIFM1 AIFM1 BAD BAD CAT CAT AREG AREG Sod2 Sod2 MAP3K5 MAP3K5 ERN1 ERN1 CAPN2 CAPN2 CCS CCS FANCC FANCC STK26 STK26 UBE3A UBE3A ENSSTOP00000030879 ENSSTOP00000030879 NOS3 NOS3 MAPK9 MAPK9 PTK2B PTK2B ENSSTOP00000030023 ENSSTOP00000030023 MPO MPO SCGB1A1 SCGB1A1 CRYAB CRYAB APEX1 APEX1 Plekha1 Plekha1 UCP2 UCP2 Ankzf1 Ankzf1 PDGFRA PDGFRA TXNRD2 TXNRD2 PAX2 PAX2 PTPRK PTPRK BNIP3 BNIP3 MAPK8 MAPK8 HDAC2 HDAC2 STAT6 STAT6 SMPD3 SMPD3 TXNIP TXNIP HDAC6 HDAC6 PCGF2 PCGF2 Rhob Rhob MAPK1 MAPK1 PLD2 PLD2 ROMO1 ROMO1 Aqp1 Aqp1 OSER1 OSER1 PARP1 PARP1 NQO1 NQO1 HYAL1 HYAL1 CHUK CHUK ZNF580 ZNF580 SIRT1 SIRT1 IMPACT IMPACT PPARGC1B PPARGC1B ADPRHL2 ADPRHL2 Cfl1 Cfl1 EZH2 EZH2 BAK1 BAK1 CAPN1 CAPN1 AGAP3 AGAP3 AXL AXL FKBP1B FKBP1B ENSSTOP00000028944 ENSSTOP00000028944 AKT1 AKT1 PDK2 PDK2 CDK1 CDK1 MT-ND5 MT-ND5 SIGMAR1 SIGMAR1 MPV17 MPV17 MT-ND6 MT-ND6 ENSSTOP00000027321 ENSSTOP00000027321 HYAL2 HYAL2 ENSSTOP00000027050 ENSSTOP00000027050 HSF1 HSF1 HMOX1 HMOX1 LIG1 LIG1 ATG7 ATG7 I3MU87_ICTTR I3MU87_ICTTR STK25 STK25 BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR Ect2 Ect2 MMP2 MMP2 PJVK PJVK TRPM2 TRPM2 RELA RELA CASP6 CASP6 COA8 COA8 I3N090_ICTTR I3N090_ICTTR COL1A1 COL1A1 ENSSTOP00000025283 ENSSTOP00000025283 Becn1 Becn1 ALDH3A2 ALDH3A2 LOC101960206 LOC101960206 TREX1 TREX1 SETX SETX I3N6Q6_ICTTR I3N6Q6_ICTTR Pdcd10 Pdcd10 I3N7W8_ICTTR I3N7W8_ICTTR LOC101956215 LOC101956215 I3N9L4_ICTTR I3N9L4_ICTTR ANXA1 ANXA1 ADAM9 ADAM9 CAPN14 CAPN14 APOD APOD SPHK1 SPHK1 JUN JUN Prdx2 Prdx2 KDM6B KDM6B PPP1R15B PPP1R15B Pcna Pcna PARK7 PARK7 MT3 MT3 PDGFRB PDGFRB DICER1 DICER1 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NME8NME/NM23 family member 8. (518 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (201 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
PRDX1Peroxiredoxin 1. (199 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
ENSSTOP00000024247Uncharacterized protein. (327 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (244 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
RNF112Ring finger protein 112. (645 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
EDN1Endothelin 1. (202 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
Glrx2Glutaredoxin domain-containing protein. (122 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
NUDT15Nudix hydrolase 15. (171 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
PRDX3Peroxiredoxin 3. (257 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (903 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1521 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
ZNF277Zinc finger protein 277. (458 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
KPNA4Karyopherin subunit alpha 4. (601 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
FABP1Fatty acid binding protein 1. (127 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (630 aa)
BTKTyrosine-protein kinase. (659 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
Hif1aUncharacterized protein. (821 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1. (1044 aa)
NOX1NADPH oxidase 1. (561 aa)
APTXAprataxin. (334 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
LOC101973389Uncharacterized protein. (182 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
SLC4A1Anion exchange protein. (917 aa)
STK24Serine/threonine kinase 24. (432 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
FYNTyrosine-protein kinase. (537 aa)
NET1Neuroepithelial cell transforming 1. (595 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
BADBCL2 associated agonist of cell death. (208 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
AREGAmphiregulin. (252 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
STK26Serine/threonine kinase 26. (416 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (874 aa)
ENSSTOP00000030879Uncharacterized protein. (105 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ENSSTOP00000030023BTB domain-containing protein; Belongs to the potassium channel family. (530 aa)
MPOMyeloperoxidase. (718 aa)
SCGB1A1Secretoglobin family 1A member 1. (93 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
Plekha1Uncharacterized protein. (343 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
Ankzf1ANK_REP_REGION domain-containing protein. (541 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TXNRD2Thioredoxin reductase 2. (522 aa)
PAX2Paired box 2. (417 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1392 aa)
BNIP3BCL2 interacting protein 3. (217 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
TXNIPThioredoxin interacting protein. (391 aa)
HDAC6Histone deacetylase 6. (1142 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
RhobUncharacterized protein. (196 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
PLD2Phospholipase. (933 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (275 aa)
HYAL1Hyaluronidase. (449 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
ZNF580Zinc finger protein 580. (172 aa)
SIRT1Sirtuin 1. (602 aa)
IMPACTImpact RWD domain protein. (297 aa)
PPARGC1BPPARG coactivator 1 beta. (1033 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (389 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (743 aa)
AGAP3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (843 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ENSSTOP00000028944Uncharacterized protein. (169 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
MT-ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (605 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
MT-ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (174 aa)
ENSSTOP00000027321Uncharacterized protein. (207 aa)
HYAL2Hyaluronidase. (472 aa)
ENSSTOP00000027050Thioredoxin domain-containing protein. (188 aa)
HSF1Heat shock transcription factor 1. (545 aa)
HMOX1Heme oxygenase 1. (288 aa)
LIG1DNA ligase. (922 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
I3MU87_ICTTRProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
STK25Serine/threonine kinase 25. (421 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
Ect2Uncharacterized protein. (188 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
PJVKPejvakin. (348 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (268 aa)
COA8Cytochrome c oxidase assembly factor 8. (170 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
COL1A1Collagen type I alpha 1 chain. (1268 aa)
ENSSTOP00000025283Uncharacterized protein; Belongs to the potassium channel family. (501 aa)
Becn1Beclin 1. (448 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
LOC101960206Uncharacterized protein. (207 aa)
TREX1Three prime repair exonuclease 1. (304 aa)
SETXSenataxin. (2708 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
Pdcd10Programmed cell death 10. (212 aa)
I3N7W8_ICTTRUncharacterized protein; Belongs to the TCP-1 chaperonin family. (202 aa)
LOC101956215Uncharacterized protein. (195 aa)
I3N9L4_ICTTRProtein kinase domain-containing protein. (388 aa)
ANXA1Annexin. (346 aa)
ADAM9ADAM metallopeptidase domain 9. (782 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (674 aa)
APODApolipoprotein D. (193 aa)
SPHK1Sphingosine kinase 1. (385 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Prdx2Thioredoxin domain-containing protein. (198 aa)
KDM6BLysine demethylase 6B. (1651 aa)
PPP1R15BProtein phosphatase 1 regulatory subunit 15B. (713 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (16%) [HD]