STRINGSTRING
SNX10 SNX10 LEF1 LEF1 Anxa2 Anxa2 SBNO2 SBNO2 MEF2C MEF2C NRROS NRROS SH3PXD2A SH3PXD2A ZBTB46 ZBTB46 ATP6AP1 ATP6AP1 KITLG KITLG THOC5 THOC5 PDE1B PDE1B TCIRG1 TCIRG1 NF1 NF1 APP APP CD109 CD109 RELB RELB PIK3R1 PIK3R1 LOC101961139 LOC101961139 RBPJ RBPJ TCTA TCTA BAP1 BAP1 PSEN1 PSEN1 JUNB JUNB TGFBR2 TGFBR2 PSEN2 PSEN2 GPR68 GPR68 BATF2 BATF2 MAPK14 MAPK14 CD4 CD4 Dusp15 Dusp15 OSCAR OSCAR TSPAN2 TSPAN2 Foxp1 Foxp1 TLR2 TLR2 JUN JUN CASP10 CASP10 EFNA2 EFNA2 GATA1 GATA1 F2RL1 F2RL1 DCSTAMP DCSTAMP SPI1 SPI1 SP3 SP3 SOCS1 SOCS1 UBD UBD GPR183 GPR183 CSF1 CSF1 OCSTAMP OCSTAMP FAM20C FAM20C LOC106144927 LOC106144927 TNFRSF11A TNFRSF11A CBFA2T3 CBFA2T3 BATF BATF MYH9 MYH9 ZFPM1 ZFPM1 MED1 MED1 Cebpa Cebpa CCR7 CCR7 IL17C IL17C CSF1R CSF1R CCN4 CCN4 TYROBP TYROBP SFRP1 SFRP1 FARP2 FARP2 IAPP IAPP SIRT1 SIRT1 CHUK CHUK ITGB8 ITGB8 Tob2 Tob2 CTNNB1 CTNNB1 SRP54 SRP54 AP3B1 AP3B1 CSF2 CSF2 LTBR LTBR TNF TNF PPARG PPARG I3MIQ6_ICTTR I3MIQ6_ICTTR CALCR CALCR Spib Spib IRF4 IRF4 CASP8 CASP8 NKX2-3 NKX2-3 FASN FASN TREM2 TREM2 TNFSF11 TNFSF11 GPC3 GPC3 L3MBTL3 L3MBTL3 TGFB1 TGFB1 LOC101968188 LOC101968188 IREB2 IREB2 EIF2AK1 EIF2AK1 LRRK1 LRRK1 GBA GBA CITED2 CITED2 ITGB6 ITGB6 NFATC1 NFATC1 TRAF6 TRAF6 CEBPE CEBPE BATF3 BATF3 PIR PIR IL20 IL20 HHEX HHEX GATA2 GATA2 LBR LBR MITF MITF GLO1 GLO1 IL15 IL15 DHRS7B DHRS7B IL31RA IL31RA NOTCH2 NOTCH2 CAMK4 CAMK4 TFRC TFRC GAB2 GAB2 EPHA2 EPHA2 FOS FOS CCL19 CCL19 IL25 IL25 PAFAH1B1 PAFAH1B1 KDM1A KDM1A TMEM64 TMEM64 BMP4 BMP4 GATA3 GATA3 GAB3 GAB3 KIT KIT CD81 CD81
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNX10Sorting nexin 10. (201 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
Anxa2Annexin. (339 aa)
SBNO2Strawberry notch homolog 2. (1382 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
NRROSNegative regulator of reactive oxygen species. (732 aa)
SH3PXD2ASH3 and PX domains 2A. (1106 aa)
ZBTB46Zinc finger and BTB domain containing 46. (598 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
THOC5THO complex 5. (695 aa)
PDE1BPhosphodiesterase. (535 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (861 aa)
NF1Neurofibromin 1. (2473 aa)
APPAmyloid beta precursor protein. (739 aa)
CD109CD109 molecule. (1235 aa)
RELBRELB proto-oncogene, NF-kB subunit. (567 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC101961139Anti_prolifrtn domain-containing protein. (290 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
TCTAT cell leukemia translocation altered. (133 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (274 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CD4CD4 molecule. (451 aa)
Dusp15IRF tryptophan pentad repeat domain-containing protein. (433 aa)
OSCAROsteoclast associated Ig-like receptor. (277 aa)
TSPAN2Tetraspanin. (231 aa)
Foxp1Fork-head domain-containing protein. (674 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (197 aa)
GATA1GATA binding protein 1. (413 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (474 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
SP3Sp3 transcription factor. (690 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
UBDUbiquitin D. (164 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
CSF1Colony stimulating factor 1. (497 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (469 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (580 aa)
LOC106144927AIG1-type G domain-containing protein. (307 aa)
TNFRSF11ATNF receptor superfamily member 11a. (625 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (616 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
ZFPM1Zinc finger protein, FOG family member 1. (783 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
CebpaUncharacterized protein. (122 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IL17CInterleukin 17C. (207 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
CCN4Cellular communication network factor 4. (366 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1063 aa)
IAPPIslet amyloid polypeptide. (93 aa)
SIRT1Sirtuin 1. (602 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
Tob2Uncharacterized protein. (345 aa)
CTNNB1Catenin beta 1. (781 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1083 aa)
CSF2Colony stimulating factor 2. (138 aa)
LTBRLymphotoxin beta receptor. (435 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
I3MIQ6_ICTTRUncharacterized protein. (168 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (497 aa)
SpibETS domain-containing protein. (262 aa)
IRF4Interferon regulatory factor 4. (451 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NKX2-3NK2 homeobox 3. (360 aa)
FASNFatty acid synthase. (2467 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (699 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC101968188Ig-like domain-containing protein. (266 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (623 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
GBAGlucosylceramidase. (516 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (786 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (122 aa)
PIRPirin; Belongs to the pirin family. (291 aa)
IL20Interleukin 20. (176 aa)
HHEXHematopoietically expressed homeobox. (272 aa)
GATA2GATA binding protein 2. (481 aa)
LBRLamin B receptor. (629 aa)
MITFMelanocyte inducing transcription factor. (482 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (185 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
IL31RAInterleukin 31 receptor A. (704 aa)
NOTCH2Notch receptor 2. (2364 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
TFRCTransferrin receptor. (760 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
EPHA2EPH receptor A2. (923 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CCL19C-C motif chemokine. (135 aa)
IL25Interleukin 25. (169 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (411 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (755 aa)
TMEM64Transmembrane protein 64. (313 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GATA3GATA binding protein 3. (444 aa)
GAB3GRB2 associated binding protein 3. (585 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
CD81Tetraspanin. (214 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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