STRINGSTRING
LIG4 LIG4 DCLRE1C DCLRE1C POLM POLM ERCC1 ERCC1 ERCC6 ERCC6 KDM2A KDM2A ERCC8 ERCC8 MLH1 MLH1 POLB POLB LIG3 LIG3 XRCC5 XRCC5 TP53BP1 TP53BP1 IFFO1 IFFO1 IFFO2 IFFO2 XRCC6 XRCC6 PRKDC PRKDC POLQ POLQ POLL POLL DNTT DNTT ERCC4 ERCC4 I3MLW0_ICTTR I3MLW0_ICTTR APLF APLF DCLRE1B DCLRE1B PSMD14 PSMD14 SMARCAL1 SMARCAL1 XRCC1 XRCC1 HELQ HELQ UVRAG UVRAG LOC101962206 LOC101962206 PNKP PNKP DCLRE1A DCLRE1A XRCC4 XRCC4 ZBTB7A ZBTB7A PAXX PAXX MRE11 MRE11 Pola1 Pola1 LIG1 LIG1 HMCES HMCES CYREN CYREN PRPF19 PRPF19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIG4DNA ligase. (911 aa)
DCLRE1CDNA cross-link repair 1C. (689 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1521 aa)
KDM2ALysine demethylase 2A. (1162 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
MLH1MutL homolog 1. (758 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (306 aa)
LIG3DNA ligase. (1013 aa)
XRCC5X-ray repair cross complementing 5. (734 aa)
TP53BP1Tumor protein p53 binding protein 1. (1968 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (564 aa)
IFFO2Intermediate filament family orphan 2; Belongs to the intermediate filament family. (287 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
POLQDNA polymerase theta. (2588 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (467 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
I3MLW0_ICTTRUncharacterized protein. (78 aa)
APLFAprataxin and PNKP like factor. (519 aa)
DCLRE1BDNA cross-link repair 1B. (533 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (936 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
HELQHelicase, POLQ like. (1017 aa)
UVRAGUV radiation resistance associated. (698 aa)
LOC101962206Uncharacterized protein. (302 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (520 aa)
DCLRE1ADNA cross-link repair 1A. (1044 aa)
XRCC4X-ray repair cross complementing 4. (330 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (414 aa)
PAXXPAXX non-homologous end joining factor. (206 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
Pola1DNA polymerase. (767 aa)
LIG1DNA ligase. (922 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (291 aa)
CYRENCell cycle regulator of NHEJ. (173 aa)
PRPF19Pre-mRNA processing factor 19. (512 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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