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| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (631 aa) |
| | I3LWG0_ICTTR | RECA_2 domain-containing protein. (187 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | INO80 | INO80 complex ATPase subunit. (1560 aa) |
| | Brca1 | Uncharacterized protein. (353 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (780 aa) |
| | I3LWU8_ICTTR | Uncharacterized protein. (69 aa) |
| | INTS3 | Integrator complex subunit 3. (1040 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (329 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (307 aa) |
| | POLN | DNA polymerase nu. (843 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (807 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (253 aa) |
| | LOC101954381 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1451 aa) |
| | I3LZW4_ICTTR | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (689 aa) |
| | REC8 | REC8 meiotic recombination protein. (594 aa) |
| | RNF138 | Ring finger protein 138. (244 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (278 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | RAD51C | RAD51 paralog C. (360 aa) |
| | CDC45 | Cell division cycle 45. (567 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (260 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (567 aa) |
| | RPAIN | RPA interacting protein. (219 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (359 aa) |
| | FANCB | FA complementation group B. (850 aa) |
| | I3M447_ICTTR | RING-type domain-containing protein. (102 aa) |
| | FOXP3 | Forkhead box P3. (431 aa) |
| | RPA2 | Replication protein A2. (271 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (422 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (384 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1534 aa) |
| | BLM | BLM RecQ like helicase. (1414 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | I3M6A8_ICTTR | Uncharacterized protein. (968 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (306 aa) |
| | LIG3 | DNA ligase. (1013 aa) |
| | Pms2 | MutL_C domain-containing protein. (461 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (259 aa) |
| | Bivm | Uncharacterized protein. (503 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (606 aa) |
| | LOC101968680 | ERCC excision repair 5, endonuclease. (1170 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (734 aa) |
| | FBH1 | F-box DNA helicase 1. (1042 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | LOC101966186 | Uncharacterized protein. (159 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | HDGFL2 | HDGF like 2. (672 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1602 aa) |
| | I3MBP4_ICTTR | Helicase ATP-binding domain-containing protein. (465 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (529 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) |
| | CENPS | Centromere protein S. (138 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (211 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | TEX11 | Testis expressed 11. (918 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1312 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (862 aa) |
| | I3MEP9_ICTTR | Uncharacterized protein. (396 aa) |
| | TEP1 | Telomerase associated protein 1. (2608 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (808 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (204 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (948 aa) |
| | AICDA | Activation induced cytidine deaminase. (198 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (937 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (382 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | Sem1 | Uncharacterized protein. (70 aa) |
| | Rbbp8 | CtIP_N domain-containing protein. (773 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (334 aa) |
| | Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1256 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (182 aa) |
| | C11orf80 | Chromosome 11 open reading frame 80. (714 aa) |
| | CNTD1 | Cyclin N-terminal domain containing 1. (333 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (592 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa) |
| | Msh5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa) |
| | HROB | Chromosome 17 open reading frame 53. (614 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | Nabp1 | Uncharacterized protein. (199 aa) |
| | WRN | WRN RecQ like helicase. (1448 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | I3MLW0_ICTTR | Uncharacterized protein. (78 aa) |
| | FANCD2 | FA complementation group D2. (1276 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1095 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (913 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | NIPBL | Nipped-B protein. (2803 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1007 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa) |
| | HDAC10 | Histone deacetylase 10. (697 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2528 aa) |
| | RAD51B | RAD51 paralog B. (258 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13. (349 aa) |
| | INO80C | INO80 complex subunit C. (192 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (850 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | Palb2 | PALB2_WD40 domain-containing protein. (384 aa) |
| | TCF7 | Transcription factor 7. (302 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (654 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1897 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (724 aa) |
| | HELQ | Helicase, POLQ like. (1017 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (140 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (273 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1748 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (274 aa) |
| | CEP63 | Centrosomal protein 63. (700 aa) |
| | MSH3 | MutS homolog 3. (1031 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (807 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | RNF212B | Ring finger protein 212B. (299 aa) |
| | KDM4D | Lysine demethylase 4D. (506 aa) |
| | I3N7W8_ICTTR | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (202 aa) |
| | CUNH19orf57 | Uncharacterized protein. (666 aa) |
| | RAG2 | Recombination activating 2. (526 aa) |
| | Swi5 | Uncharacterized protein. (185 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (330 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | Tm4sf19 | Uncharacterized protein. (210 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (548 aa) |
| | Foxp1 | Fork-head domain-containing protein. (674 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (630 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | Mcmdc2 | Uncharacterized protein. (358 aa) |
| | Rad51ap2 | RAD51_interact domain-containing protein. (974 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | EXOSC6 | Exosome component 6. (272 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (894 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (413 aa) |
| | EID3 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (367 aa) |
| | SYCE3 | Synaptonemal complex central element protein 3. (88 aa) |
| | ENSSTOP00000024032 | Uncharacterized protein. (129 aa) |
| | LOC101977976 | Uncharacterized protein. (262 aa) |
| | MBTD1 | Mbt domain containing 1. (634 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | Yy1 | Uncharacterized protein. (190 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa) |
| | ENSSTOP00000025631 | Uncharacterized protein. (117 aa) |
| | KIAA1841 | KIAA1841. (717 aa) |
| | ENSSTOP00000026046 | RING-type domain-containing protein. (264 aa) |
| | LIG1 | DNA ligase. (922 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | ENSSTOP00000026616 | Uncharacterized protein. (174 aa) |
| | ENSSTOP00000026660 | Uncharacterized protein. (178 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ANKRD31 | Ankyrin repeat domain 31. (1764 aa) |
| | Hmgb1 | Uncharacterized protein. (188 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa) |
| | CDC7 | Cell division cycle 7; Belongs to the protein kinase superfamily. (498 aa) |
| | ENSSTOP00000027930 | Uncharacterized protein. (173 aa) |
| | GINS2 | GINS complex subunit 2. (141 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa) |
| | ENSSTOP00000028194 | SAE2 domain-containing protein. (75 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (583 aa) |
| | EPC1 | Enhancer of polycomb homolog. (835 aa) |
| | ENSSTOP00000028611 | Uncharacterized protein. (195 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1245 aa) |
| | ENSSTOP00000028911 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1103 aa) |
| | Mcm8 | MCM domain-containing protein; Belongs to the MCM family. (833 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | LOC101960243 | Uncharacterized protein. (175 aa) |
| | ENSSTOP00000029801 | RING-type domain-containing protein. (191 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (388 aa) |
| | TPRKB | TP53RK binding protein; Belongs to the CGI121/TPRKB family. (175 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (173 aa) |
| | Rad54b | Uncharacterized protein. (917 aa) |
| | Cenpx | Uncharacterized protein. (79 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (594 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (399 aa) |
