STRINGSTRING
INCA1 INCA1 CORO1C CORO1C DUSP10 DUSP10 CHORDC1 CHORDC1 MYOCD MYOCD ZGPAT ZGPAT STK38 STK38 TAF7 TAF7 CBLB CBLB SFRP5 SFRP5 NCAPG2 NCAPG2 ZFYVE28 ZFYVE28 LRP5 LRP5 RASIP1 RASIP1 PLK1 PLK1 BMP7 BMP7 PPARG PPARG AKT1S1 AKT1S1 PPM1E PPM1E PRKAR1A PRKAR1A PDPK1 PDPK1 CDK5RAP2 CDK5RAP2 DVL1 DVL1 TSC2 TSC2 PTPRB PTPRB CAV3 CAV3 PYCARD PYCARD LATS1 LATS1 WARS1 WARS1 Dusp3 Dusp3 CDKN2C CDKN2C DEPTOR DEPTOR ADAR ADAR I3MMQ2_ICTTR I3MMQ2_ICTTR RGN RGN CHP1 CHP1 MACROH2A1 MACROH2A1 SH3BP5 SH3BP5 LRP6 LRP6 PKIG PKIG ADARB1 ADARB1 ADIPOQ ADIPOQ GSKIP GSKIP DUSP1 DUSP1 HEXIM1 HEXIM1 CDKN1B CDKN1B SIRT1 SIRT1 CAMK2N2 CAMK2N2 CAV1 CAV1 DRD1 DRD1 PTEN PTEN NUP62 NUP62 TRIB1 TRIB1 GSTP1 GSTP1 I3MVL6_ICTTR I3MVL6_ICTTR SMCR8 SMCR8 SFRP1 SFRP1 Spry2 Spry2 GADD45G GADD45G AGT AGT Fam72a Fam72a DBNDD2 DBNDD2 MAPK8IP1 MAPK8IP1 I3N090_ICTTR I3N090_ICTTR I3N0K9_ICTTR I3N0K9_ICTTR SH3BP5L SH3BP5L FBXO7 FBXO7 TESK1 TESK1 Cdkn2d Cdkn2d SMYD3 SMYD3 NF2 NF2 GADD45B GADD45B LOC101960206 LOC101960206 DAB2IP DAB2IP BMP2 BMP2 Tsg101 Tsg101 LOC101974931 LOC101974931 Ptprh Ptprh HSPB1 HSPB1 CHMP6 CHMP6 CDKN1A CDKN1A CAMK2N1 CAMK2N1 PTPN1 PTPN1 DNAJA3 DNAJA3 DUSP19 DUSP19 RB1 RB1 PTPN5 PTPN5 SH2B3 SH2B3 BMP4 BMP4 PIK3CB PIK3CB MVP MVP DUSP22 DUSP22 QARS1 QARS1 IL1B IL1B SFRP2 SFRP2 MLLT1 MLLT1 GGNBP2 GGNBP2 LOC101973790 LOC101973790 RGS2 RGS2 SORL1 SORL1 VPS25 VPS25 IBTK IBTK SLC8A3 SLC8A3 SOCS4 SOCS4 PRKCD PRKCD I3M4W8_ICTTR I3M4W8_ICTTR INPP5K INPP5K CEP85 CEP85 EPHA1 EPHA1 CBL CBL THY1 THY1 CDK5RAP1 CDK5RAP1 SPRED1 SPRED1 PAQR3 PAQR3 HHEX HHEX CDK5RAP3 CDK5RAP3 RACK1 RACK1 IRAK3 IRAK3 PTPN2 PTPN2 I3MA50_ICTTR I3MA50_ICTTR PTK6 PTK6 TNFAIP3 TNFAIP3 RGS14 RGS14 Fabp4 Fabp4 TRIB3 TRIB3 GBA GBA PTPRT PTPRT SMPD1 SMPD1 HMGCR HMGCR HIPK3 HIPK3 ERRFI1 ERRFI1 ACP4 ACP4 PKIA PKIA TMEM130 TMEM130 INPPL1 INPPL1 ENSSTOP00000028075 ENSSTOP00000028075 UBASH3B UBASH3B LOC101954990 LOC101954990 PTPRO PTPRO AKT1 AKT1 ENSSTOP00000029018 ENSSTOP00000029018 PKIB PKIB ENSSTOP00000029359 ENSSTOP00000029359 LYN LYN PDCD4 PDCD4 PTPN6 PTPN6 HEXIM2 HEXIM2 PPM1F PPM1F ENSSTOP00000031788 ENSSTOP00000031788 APC APC PRKAR2B PRKAR2B DRD5 DRD5 HEG1 HEG1 SPRY1 SPRY1 LATS2 LATS2 CDKN2B CDKN2B PTPRQ PTPRQ LAX1 LAX1 SOCS5 SOCS5 Shb Shb TFAP4 TFAP4 I3ND30_ICTTR I3ND30_ICTTR I3NE23_ICTTR I3NE23_ICTTR DUSP16 DUSP16 GSK3B GSK3B SPRY4 SPRY4 PSEN2 PSEN2 TRIM27 TRIM27 PSEN1 PSEN1 PRKAR2A PRKAR2A GPRC5A GPRC5A PKN1 PKN1 ITGB1BP1 ITGB1BP1 PTPRC PTPRC EPHB2 EPHB2 SRCIN1 SRCIN1 PRKAG2 PRKAG2 NF1 NF1 HYAL2 HYAL2 UCHL1 UCHL1 MEN1 MEN1 PTPRJ PTPRJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INCA1Inhibitor of CDK, cyclin A1 interacting protein 1. (233 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (332 aa)
MYOCDMyocardin. (894 aa)
ZGPATZinc finger CCCH-type and G-patch domain containing. (465 aa)
STK38Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa)
TAF7TATA-box binding protein associated factor 7. (349 aa)
CBLBCbl proto-oncogene B. (985 aa)
SFRP5Secreted frizzled related protein 5. (316 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1139 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (910 aa)
LRP5Uncharacterized protein. (1516 aa)
RASIP1Ras interacting protein 1. (963 aa)
PLK1Serine/threonine-protein kinase PLK. (601 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
AKT1S1AKT1 substrate 1. (274 aa)
PPM1EProtein phosphatase, Mg2+/Mn2+ dependent 1E. (747 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1860 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
TSC2TSC complex subunit 2. (1745 aa)
PTPRBProtein tyrosine phosphatase receptor type B. (1998 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PYCARDPYD and CARD domain containing. (194 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (475 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (170 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
ADARAdenosine deaminase RNA specific. (1165 aa)
I3MMQ2_ICTTRUncharacterized protein. (384 aa)
RGNRegucalcin. (299 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
SH3BP5SH3 domain binding protein 5. (390 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
ADARB1Adenosine deaminase RNA specific B1. (700 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
GSKIPGSK3B interacting protein. (143 aa)
DUSP1Dual specificity phosphatase 1. (272 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (355 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SIRT1Sirtuin 1. (602 aa)
CAMK2N2Calcium/calmodulin dependent protein kinase II inhibitor 2. (79 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NUP62Nucleoporin 62. (520 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
Spry2Uncharacterized protein. (315 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
Fam72aUncharacterized protein. (149 aa)
DBNDD2Dysbindin domain containing 2. (160 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (697 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
I3N0K9_ICTTRUncharacterized protein. (198 aa)
SH3BP5LSH3 binding domain protein 5 like. (393 aa)
FBXO7F-box protein 7. (440 aa)
TESK1Testis associated actin remodelling kinase 1. (587 aa)
Cdkn2dANK_REP_REGION domain-containing protein. (166 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
NF2Neurofibromin 2. (596 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LOC101960206Uncharacterized protein. (207 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
Tsg101SB domain-containing protein. (325 aa)
LOC101974931Tyrosine-protein phosphatase non-receptor type. (433 aa)
PtprhUncharacterized protein. (455 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
CAMK2N1Calcium/calmodulin dependent protein kinase II inhibitor 1. (78 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (413 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
RB1RB transcriptional corepressor 1. (957 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (538 aa)
SH2B3SH2B adaptor protein 3. (429 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MVPMajor vault protein. (759 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
QARS1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
MLLT1MLLT1 super elongation complex subunit. (552 aa)
GGNBP2Gametogenetin binding protein 2. (738 aa)
LOC101973790Uncharacterized protein. (311 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
SORL1Sortilin related receptor 1. (2199 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1354 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (929 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (510 aa)
CEP85Centrosomal protein 85. (761 aa)
EPHA1EPH receptor A1. (978 aa)
CBLCbl proto-oncogene. (870 aa)
THY1Thy-1 cell surface antigen. (162 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (587 aa)
SPRED1Sprouty related EVH1 domain containing 1. (445 aa)
PAQR3Progestin and adipoQ receptor family member 3. (311 aa)
HHEXHematopoietically expressed homeobox. (272 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (502 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (607 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (389 aa)
I3MA50_ICTTRUncharacterized protein. (220 aa)
PTK6Tyrosine-protein kinase. (450 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
RGS14Regulator of G protein signaling 14. (568 aa)
Fabp4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). FABPs are important elements related to the hibernating state in mammals. (132 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
GBAGlucosylceramidase. (516 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1421 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
HIPK3Homeodomain interacting protein kinase 3. (1214 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
ACP4Acid phosphatase 4; Belongs to the histidine acid phosphatase family. (422 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
TMEM130Transmembrane protein 130. (338 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
LOC101954990Tyrosine-protein phosphatase domain-containing protein. (231 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000029018UEV domain-containing protein. (97 aa)
PKIBcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (78 aa)
ENSSTOP00000029359Uncharacterized protein. (65 aa)
LYNTyrosine-protein kinase. (512 aa)
PDCD4Programmed cell death 4. (469 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
HEXIM2HEXIM P-TEFb complex subunit 2. (286 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (452 aa)
ENSSTOP00000031788Aida_C2 domain-containing protein. (135 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (417 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (480 aa)
HEG1Heart development protein with EGF like domains 1. (1314 aa)
SPRY1Sprouty RTK signaling antagonist 1. (315 aa)
LATS2Large tumor suppressor kinase 2. (1060 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2237 aa)
LAX1Lymphocyte transmembrane adaptor 1. (382 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ShbSH2 domain-containing protein. (495 aa)
TFAP4Transcription factor AP-4. (338 aa)
I3ND30_ICTTRUncharacterized protein. (158 aa)
I3NE23_ICTTRANK_REP_REGION domain-containing protein. (150 aa)
DUSP16Dual specificity phosphatase 16. (660 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
TRIM27Tripartite motif containing 27. (513 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (399 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (357 aa)
PKN1Protein kinase N1. (947 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1180 aa)
EPHB2EPH receptor B2. (978 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1234 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
NF1Neurofibromin 1. (2473 aa)
HYAL2Hyaluronidase. (472 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (223 aa)
MEN1Menin 1. (616 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1197 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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