STRINGSTRING
WNT4 WNT4 MAPK3 MAPK3 ENDOU ENDOU CYP27B1 CYP27B1 BMPR2 BMPR2 PRDX3 PRDX3 ATP7A ATP7A RGS2 RGS2 Itgb3 Itgb3 EPOR EPOR ANGPT2 ANGPT2 FOSL1 FOSL1 UBE2Q1 UBE2Q1 CALCA CALCA HMX3 HMX3 GIP GIP STC2 STC2 CRH CRH ACSL4 ACSL4 UMPS UMPS I3M6M8_ICTTR I3M6M8_ICTTR SP1 SP1 LIF LIF MMP9 MMP9 DEDD DEDD DAZAP1 DAZAP1 ACE2 ACE2 MAGED2 MAGED2 STAT5B STAT5B STAT5A STAT5A STC1 STC1 I3MA50_ICTTR I3MA50_ICTTR CTSV CTSV ITGA5 ITGA5 POLR1B POLR1B Cuzd1 Cuzd1 CITED2 CITED2 CSMD2 CSMD2 CAPN2 CAPN2 CRHBP CRHBP Ptgs2 Ptgs2 ITGA2 ITGA2 UCP2 UCP2 NDP NDP IGFBP2 IGFBP2 UCN UCN CSMD1 CSMD1 PCSK5 PCSK5 SPHK2 SPHK2 NODAL NODAL EPO EPO MST1 MST1 MAPK1 MAPK1 ITGA3 ITGA3 LOC101967926 LOC101967926 TCF23 TCF23 GHSR GHSR SLC38A3 SLC38A3 LOC101965973 LOC101965973 VMP1 VMP1 SLC38A1 SLC38A1 SLC38A2 SLC38A2 HSD11B2 HSD11B2 AGRP AGRP PRDM1 PRDM1 EXOC1 EXOC1 LEP LEP AR AR ATR ATR LDOC1 LDOC1 FUT7 FUT7 RXRA RXRA MMP2 MMP2 AGT AGT I3MYY7_ICTTR I3MYY7_ICTTR I3MXG6_ICTTR I3MXG6_ICTTR FBLN1 FBLN1 ENSSTOP00000017333 ENSSTOP00000017333 IGFBP5 IGFBP5 H3-3A H3-3A TRIM28 TRIM28 MED1 MED1 ACOD1 ACOD1 I3N0W3_ICTTR I3N0W3_ICTTR OXTR OXTR EMP2 EMP2 ADIPOR2 ADIPOR2 RXRB RXRB STS STS BSG BSG ASH1L ASH1L TPPP3 TPPP3 COMT COMT PGR PGR PTGIS PTGIS GJB2 GJB2 LOC101967640 LOC101967640 PGF PGF ITGB4 ITGB4 SP3 SP3 ENSSTOP00000020850 ENSSTOP00000020850 TEAD4 TEAD4 PRDM14 PRDM14 IHH IHH PTN PTN CAPN14 CAPN14 LOC101976584 LOC101976584 LOC101963257 LOC101963257 TGFB3 TGFB3 CNR1 CNR1 FOSB FOSB HPGD HPGD PPARD PPARD LOC101968945 LOC101968945 GHRL GHRL FKBP4 FKBP4 I3NHR2_ICTTR I3NHR2_ICTTR LAMB1 LAMB1 PAM PAM Prl Prl TGFBR2 TGFBR2 JUNB JUNB RARA RARA STOX2 STOX2 HSF1 HSF1 Cbs Cbs ADM ADM DDR1 DDR1 SLC2A1 SLC2A1 Arid1a Arid1a TMED2 TMED2 MEN1 MEN1 KISS1 KISS1 AKT1 AKT1 ADCY7 ADCY7 PAPPA PAPPA GGN GGN PLA2G4A PLA2G4A CORIN CORIN RECK RECK PLA2G6 PLA2G6 VDR VDR MTOR MTOR ENSSTOP00000032295 ENSSTOP00000032295 ABCC8 ABCC8 CDH1 CDH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
ENDOUEndonuclease, poly(U) specific. (409 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PRDX3Peroxiredoxin 3. (257 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
ANGPT2Angiopoietin 2. (495 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
CALCACalcitonin related polypeptide alpha. (137 aa)
HMX3H6 family homeobox 3. (357 aa)
GIPGastric inhibitory polypeptide. (140 aa)
STC2Stanniocalcin 2. (302 aa)
CRHCorticotropin releasing hormone. (180 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
UMPSUridine monophosphate synthetase. (480 aa)
I3M6M8_ICTTRRRM domain-containing protein. (122 aa)
SP1Sp1 transcription factor. (788 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
DEDDDeath effector domain containing. (318 aa)
DAZAP1DAZ associated protein 1. (390 aa)
ACE2Angiotensin-converting enzyme. (807 aa)
MAGED2MAGE family member D2. (607 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
STC1Stanniocalcin 1. (247 aa)
I3MA50_ICTTRUncharacterized protein. (220 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (332 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1076 aa)
Cuzd1Uncharacterized protein. (607 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
CSMD2CUB and Sushi multiple domains 2. (3551 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1183 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
IGFBP2Insulin like growth factor binding protein 2. (308 aa)
UCNUrocortin. (127 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1880 aa)
SPHK2Sphingosine kinase 2. (655 aa)
NODALNodal growth differentiation factor. (350 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
LOC101967926Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
TCF23Transcription factor 23. (214 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SLC38A3Solute carrier family 38 member 3. (504 aa)
LOC101965973Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (279 aa)
VMP1Vacuole membrane protein 1. (406 aa)
SLC38A1Solute carrier family 38 member 1. (428 aa)
SLC38A2Solute carrier family 38 member 2. (509 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (398 aa)
AGRPAgouti related neuropeptide. (132 aa)
PRDM1PR/SET domain 1. (821 aa)
EXOC1Exocyst complex component 1. (901 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ARAndrogen receptor. (884 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
LDOC1LDOC1 regulator of NFKB signaling. (146 aa)
FUT7Fucosyltransferase 7. (342 aa)
RXRARetinoid X receptor alpha. (461 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
I3MYY7_ICTTRDUF4939 domain-containing protein. (113 aa)
I3MXG6_ICTTRUncharacterized protein. (191 aa)
FBLN1Fibulin 1. (599 aa)
ENSSTOP00000017333annotation not available (113 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
TRIM28Tripartite motif containing 28. (835 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
ACOD1Aconitate decarboxylase 1. (473 aa)
I3N0W3_ICTTRBAF250_C domain-containing protein. (135 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
RXRBRetinoid X receptor beta. (531 aa)
STSSteroid sulfatase. (580 aa)
BSGBasigin (Ok blood group). (389 aa)
ASH1LASH1 like histone lysine methyltransferase. (2965 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
PGRProgesterone receptor. (932 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (414 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
LOC101967640Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
ITGB4Integrin beta. (1796 aa)
SP3Sp3 transcription factor. (690 aa)
ENSSTOP00000020850annotation not available (113 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (427 aa)
PRDM14PR/SET domain 14. (499 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
PTNPleiotrophin. (142 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (674 aa)
LOC101976584DUF4939 domain-containing protein. (113 aa)
LOC101963257Histone H3; Belongs to the histone H3 family. (136 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
LOC101968945Uncharacterized protein; Belongs to the peptidase C1 family. (339 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
I3NHR2_ICTTRUncharacterized protein. (435 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (979 aa)
PrlUncharacterized protein. (227 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
RARARetinoic acid receptor alpha. (462 aa)
STOX2Storkhead box 2. (925 aa)
HSF1Heat shock transcription factor 1. (545 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (555 aa)
ADMAdrenomedullin. (188 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (915 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
Arid1aARID domain-containing protein. (1014 aa)
TMED2Transmembrane p24 trafficking protein 2. (128 aa)
MEN1Menin 1. (616 aa)
KISS1KiSS-1 metastasis suppressor. (135 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PAPPAPappalysin 1. (1549 aa)
GGNGametogenetin. (662 aa)
PLA2G4APhospholipase A2. (750 aa)
CORINCorin, serine peptidase. (1113 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (972 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
VDRVitamin D receptor. (423 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
ABCC8ATP binding cassette subfamily C member 8. (1624 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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