81 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLD2	Phospholipase. (933 aa)
	PDE8A	Phosphodiesterase. (766 aa)
	MPPED2	Metallophosphoesterase domain containing 2. (294 aa)
	PDE3B	Phosphodiesterase. (1046 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	ENPP6	Ectonucleotide pyrophosphatase/phosphodiesterase 6. (441 aa)
	PLCXD2	Phosphatidylinositol specific phospholipase C X domain containing 2. (341 aa)
	GPCPD1	Glycerophosphocholine phosphodiesterase 1. (668 aa)
	PLCH2	Phosphoinositide phospholipase C. (1480 aa)
	CCR1	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	PLCE1	Phosphoinositide phospholipase C. (2298 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	FICD	FIC domain containing. (458 aa)
	PDE6C	Phosphodiesterase. (862 aa)
	PDE4D	Phosphodiesterase 4D; Belongs to the cyclic nucleotide phosphodiesterase family. (808 aa)
	PDE5A	Phosphodiesterase. (822 aa)
	PLCL1	Phosphoinositide phospholipase C. (1096 aa)
	PLCXD1	Phosphatidylinositol specific phospholipase C X domain containing 1. (323 aa)
	SMPD4	Sphingomyelin phosphodiesterase 4. (827 aa)
	Smpd5	Endo/exonuclease/phosphatase domain-containing protein. (472 aa)
	GDPD5	Glycerophosphodiester phosphodiesterase domain containing 5. (610 aa)
	SMPD2	Sphingomyelin phosphodiesterase 2. (419 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	SMPDL3A	Acid sphingomyelinase-like phosphodiesterase. (454 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa)
	GDPD2	Glycerophosphodiester phosphodiesterase domain containing 2. (539 aa)
	PDE1C	Phosphodiesterase. (769 aa)
	Pde8b	Phosphodiesterase. (865 aa)
	PDE4A	Phosphodiesterase. (776 aa)
	PDE7A	Phosphodiesterase. (482 aa)
	PDE7B	Phosphodiesterase. (499 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
	PDE6G	Phosphodiesterase 6G. (87 aa)
	PLCH1	Phosphoinositide phospholipase C. (1685 aa)
	Pde4c	Phosphodiesterase. (563 aa)
	PDE1A	Phosphodiesterase. (544 aa)
	PLCL2	Phosphoinositide phospholipase C. (1100 aa)
	GDPD3	Glycerophosphodiester phosphodiesterase domain containing 3. (331 aa)
	PDE9A	Phosphodiesterase. (511 aa)
	PLCD1	Phosphoinositide phospholipase C. (756 aa)
	ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
	PDE10A	Phosphodiesterase. (794 aa)
	PDE3A	Phosphodiesterase. (1145 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	LOC101964456	Uncharacterized protein. (315 aa)
	PDE2A	Phosphodiesterase. (941 aa)
	HMOX1	Heme oxygenase 1. (288 aa)
	PDE4B	Phosphodiesterase. (737 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	PLCD4	Phosphoinositide phospholipase C. (783 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
	PDE6B	Phosphodiesterase. (855 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
	NAPEPLD	N-acyl phosphatidylethanolamine phospholipase D. (400 aa)
	GDPD4	Glycerophosphodiester phosphodiesterase domain containing 4. (656 aa)
	GNA11	G protein subunit alpha 11. (359 aa)
	PLD6	Phospholipase D family member 6. (222 aa)
	SMPDL3B	Acid sphingomyelinase-like phosphodiesterase. (456 aa)
	TDP1	Tyrosyl-DNA phosphodiesterase 1. (618 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
	CNP	2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (419 aa)
	SMG8	SMG8 nonsense mediated mRNA decay factor. (991 aa)
	GDPD1	Glycerophosphodiester phosphodiesterase domain containing 1. (314 aa)
	PLCXD3	Phosphatidylinositol specific phospholipase C X domain containing 3. (321 aa)
	GDE1	Glycerophosphodiester phosphodiesterase 1. (328 aa)
	PDE6A	Phosphodiesterase. (860 aa)
	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (342 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones; Belongs to the rod/cone cGMP-PDE gamma subunit family. (83 aa)
	PLCD3	Phosphoinositide phospholipase C. (782 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	PLD1	Phospholipase. (1037 aa)
	GNB1	G protein subunit beta 1. (340 aa)
	PLCZ1	Phosphoinositide phospholipase C. (594 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	MPPE1	Metallophosphoesterase 1. (391 aa)
	PLEKHD1	Pleckstrin homology and coiled-coil domain containing D1. (506 aa)
	Pde11a	Phosphodiesterase. (933 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (655 aa)
	ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7. (427 aa)
	I3MMP4_ICTTR	NUC domain-containing protein. (149 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	APEX2	ENSSTOP00000009066	ENSSTOP00000021606	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.868
APEX1	TDP1	ENSSTOP00000009066	ENSSTOP00000004341	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Tyrosyl-DNA phosphodiesterase 1.	0.692
APEX2	APEX1	ENSSTOP00000021606	ENSSTOP00000009066	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.868
APEX2	TDP1	ENSSTOP00000021606	ENSSTOP00000004341	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Tyrosyl-DNA phosphodiesterase 1.	0.677
CCR1	GNA11	ENSSTOP00000015533	ENSSTOP00000021120	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 11.	0.832
CCR1	GNAQ	ENSSTOP00000015533	ENSSTOP00000015695	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha q.	0.832
CCR1	GNB1	ENSSTOP00000015533	ENSSTOP00000009443	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	G protein subunit beta 1.	0.810
ENPP2	ENPP6	ENSSTOP00000001734	ENSSTOP00000014770	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Ectonucleotide pyrophosphatase/phosphodiesterase 6.	0.860
ENPP2	GDE1	ENSSTOP00000001734	ENSSTOP00000007722	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Glycerophosphodiester phosphodiesterase 1.	0.435
ENPP2	GDPD1	ENSSTOP00000001734	ENSSTOP00000006776	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Glycerophosphodiester phosphodiesterase domain containing 1.	0.936
ENPP2	GDPD2	ENSSTOP00000001734	ENSSTOP00000027259	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Glycerophosphodiester phosphodiesterase domain containing 2.	0.435
ENPP2	GDPD3	ENSSTOP00000001734	ENSSTOP00000000783	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Glycerophosphodiester phosphodiesterase domain containing 3.	0.936
ENPP2	GDPD4	ENSSTOP00000001734	ENSSTOP00000021438	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Glycerophosphodiester phosphodiesterase domain containing 4.	0.435
ENPP2	GDPD5	ENSSTOP00000001734	ENSSTOP00000029818	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Glycerophosphodiester phosphodiesterase domain containing 5.	0.435
ENPP2	PDE10A	ENSSTOP00000001734	ENSSTOP00000001742	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Phosphodiesterase.	0.598
ENPP2	PDE1A	ENSSTOP00000001734	ENSSTOP00000000522	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Phosphodiesterase.	0.574
ENPP2	PDE1B	ENSSTOP00000001734	ENSSTOP00000028426	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Phosphodiesterase.	0.574
ENPP2	PDE1C	ENSSTOP00000001734	ENSSTOP00000027207	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Phosphodiesterase.	0.574
ENPP2	PDE2A	ENSSTOP00000001734	ENSSTOP00000026539	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Phosphodiesterase.	0.598
ENPP2	PDE3A	ENSSTOP00000001734	ENSSTOP00000002021	Ectonucleotide pyrophosphatase/phosphodiesterase 2.	Phosphodiesterase.	0.606