STRINGSTRING
IRS1 IRS1 BMP4 BMP4 LMNA LMNA NFIB NFIB PDGFA PDGFA PHF14 PHF14 FGFR2 FGFR2 TBX1 TBX1 WNT2 WNT2 CHRD CHRD FOXP2 FOXP2 SHOX2 SHOX2 SMO SMO FBXW4 FBXW4 Mycn Mycn LRP5 LRP5 LRP6 LRP6 BMPR1A BMPR1A CTNNB1 CTNNB1 KDR KDR ZEB1 ZEB1 SHH SHH SIX1 SIX1 LOC101955349 LOC101955349 CTNNBIP1 CTNNBIP1 WNT5A WNT5A WNT11 WNT11 SOX9 SOX9 IHH IHH PTN PTN PRRX1 PRRX1 Foxp1 Foxp1 ARHGAP5 ARHGAP5 TBX18 TBX18 TGFBR2 TGFBR2 FGFR1 FGFR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRS1Insulin receptor substrate 1. (1241 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PHF14PHD finger protein 14. (945 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
TBX1T-box transcription factor 1. (406 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CHRDChordin. (898 aa)
FOXP2Forkhead box P2. (737 aa)
SHOX2Short stature homeobox 2. (319 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
FBXW4F-box and WD repeat domain containing 4. (408 aa)
MycnBHLH domain-containing protein. (460 aa)
LRP5Uncharacterized protein. (1516 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1123 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
SIX1SIX homeobox 1. (284 aa)
LOC101955349BHLH domain-containing protein. (454 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX9SRY-box transcription factor 9. (509 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
PTNPleiotrophin. (142 aa)
PRRX1Paired related homeobox 1. (245 aa)
Foxp1Fork-head domain-containing protein. (674 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
TBX18T-box transcription factor 18. (614 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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