STRINGSTRING
PRKCD PRKCD FGG FGG SH2B3 SH2B3 Cd9 Cd9 PDGFA PDGFA ALOX12 ALOX12 SERPINE2 SERPINE2 PDGFRA PDGFRA ADAMTS18 ADAMTS18 PDGFB PDGFB PTGER3 PTGER3 ABAT ABAT C1QTNF1 C1QTNF1 UBASH3B UBASH3B ENSSTOP00000028985 ENSSTOP00000028985 PRKG1 PRKG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
FGGFibrinogen gamma chain. (445 aa)
SH2B3SH2B adaptor protein 3. (429 aa)
Cd9Tetraspanin. (226 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1211 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PTGER3Prostaglandin E receptor 3. (388 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
C1QTNF1C1q and TNF related 1. (284 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
ENSSTOP00000028985Tetraspanin. (232 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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