STRINGSTRING
ZC3H12A ZC3H12A PLK2 PLK2 NFE2L2 NFE2L2 LGMN LGMN GATA3 GATA3 BMP4 BMP4 THBS1 THBS1 PIK3CB PIK3CB PIK3CG PIK3CG RRAS RRAS HDAC7 HDAC7 VEGFC VEGFC BMPR2 BMPR2 RHOJ RHOJ AMOTL1 AMOTL1 SEMA5A SEMA5A GPI GPI Itgb3 Itgb3 PRKD1 PRKD1 BCAR1 BCAR1 GRN GRN ADORA2B ADORA2B ADAM17 ADAM17 Hif1a Hif1a SRPX2 SRPX2 SP1 SP1 GATA2 GATA2 ALOX12 ALOX12 ATOH8 ATOH8 RAC1 RAC1 SPARC SPARC ANGPT1 ANGPT1 CALR CALR MAP3K3 MAP3K3 VEGFA VEGFA PIK3C2A PIK3C2A MAP2K3 MAP2K3 LOC101962660 LOC101962660 TGFB1 TGFB1 AKT3 AKT3 EMC10 EMC10 PLCG1 PLCG1 FUT1 FUT1 PDPK1 PDPK1 NRP1 NRP1 ATP5F1B ATP5F1B Rhob Rhob KDR KDR ZNF580 ZNF580 LOC101965906 LOC101965906 SHH SHH SIRT1 SIRT1 Fgf2 Fgf2 NUS1 NUS1 AGT AGT FLT4 FLT4 I3N2R3_ICTTR I3N2R3_ICTTR BSG BSG MET MET HSPB1 HSPB1 PDGFB PDGFB I3N5R7_ICTTR I3N5R7_ICTTR LOC101974597 LOC101974597 WNT5A WNT5A ANGPT4 ANGPT4 LOC101956215 LOC101956215 ANXA1 ANXA1 ANXA3 ANXA3 JCAD JCAD FGF1 FGF1 Plpp3 Plpp3 Foxp1 Foxp1 FGF18 FGF18 CD40 CD40 DICER1 DICER1 LCN2 LCN2 GPLD1 GPLD1 LOC101968118 LOC101968118 ITGB1BP1 ITGB1BP1 ADGRA2 ADGRA2 BCAS3 BCAS3 HMOX1 HMOX1 SMOC2 SMOC2 P2RX4 P2RX4 RIN2 RIN2 CIB1 CIB1 PDCD6 PDCD6 FGFR1 FGFR1 CCBE1 CCBE1 TSTA3 TSTA3 PROX1 PROX1 AKT1 AKT1 ETS1 ETS1 HDAC9 HDAC9 Pik3cd Pik3cd ATP5F1A ATP5F1A IGF1 IGF1 PTK2B PTK2B TEK TEK NOS3 NOS3 SASH1 SASH1 AMOT AMOT PRKD2 PRKD2 ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
PLK2Serine/threonine-protein kinase PLK. (683 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
LGMNLegumain. (433 aa)
GATA3GATA binding protein 3. (444 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
THBS1Thrombospondin 1. (1182 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1071 aa)
RRASRAS related. (218 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (956 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
RHOJRas homolog family member J. (214 aa)
AMOTL1Angiomotin like 1. (851 aa)
SEMA5ASemaphorin 5A. (1074 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (874 aa)
GRNGranulin precursor. (596 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
Hif1aUncharacterized protein. (821 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
SP1Sp1 transcription factor. (788 aa)
GATA2GATA binding protein 2. (481 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
ATOH8Atonal bHLH transcription factor 8. (322 aa)
RAC1Rac family small GTPase 1. (211 aa)
SPARCSecreted protein acidic and cysteine rich. (304 aa)
ANGPT1Angiopoietin 1. (497 aa)
CALRCalreticulin. (418 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1641 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EMC10ER membrane protein complex subunit 10. (223 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (378 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
RhobUncharacterized protein. (196 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
ZNF580Zinc finger protein 580. (172 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
SIRT1Sirtuin 1. (602 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (278 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
I3N2R3_ICTTRL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (376 aa)
BSGBasigin (Ok blood group). (389 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
I3N5R7_ICTTRUncharacterized protein. (445 aa)
LOC101974597L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (341 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
ANGPT4Angiopoietin 4. (496 aa)
LOC101956215Uncharacterized protein. (195 aa)
ANXA1Annexin. (346 aa)
ANXA3Annexin. (323 aa)
JCADJunctional cadherin 5 associated. (1363 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
Foxp1Fork-head domain-containing protein. (674 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CD40CD40 molecule. (284 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1335 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (943 aa)
HMOX1Heme oxygenase 1. (288 aa)
SMOC2SPARC related modular calcium binding 2. (446 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
RIN2Ras and Rab interactor 2. (899 aa)
CIB1Calcium and integrin binding 1. (191 aa)
PDCD6Programmed cell death 6. (191 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
CCBE1Collagen and calcium binding EGF domains 1. (290 aa)
TSTA3Tissue specific transplantation antigen P35B. (329 aa)
PROX1Prospero homeobox 1. (737 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
IGF1Insulin like growth factor 1. (166 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
SASH1SAM and SH3 domain containing 1. (1252 aa)
AMOTAngiomotin. (1068 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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