(27 nodes) Positive regulation of cholesterol efflux network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	ABCG1	ATP binding cassette subfamily G member 1. (666 aa)
	PTCH1	Patched 1. (1450 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (459 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (444 aa)
	LOC106145384	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (495 aa)
	I3NFT9_ICTTR	COesterase domain-containing protein. (179 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2098 aa)
	ZDHHC8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (751 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	LOC101956324	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (536 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2598 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	SIRT1	Sirtuin 1. (602 aa)
	LOC101973014	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	LRP1	LDL receptor related protein 1. (4508 aa)
	ABCA3	ATP binding cassette subfamily A member 3. (1704 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	PON1	Paraoxonase 1. (355 aa)
	LOC101971868	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (262 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	Pltp	BPI1 domain-containing protein. (147 aa)
	APOA1	Apolipoprotein A1. (264 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2261 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCA3	ENSSTOP00000001138	ENSSTOP00000011846	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily A member 3.	0.539
ABCA1	APOA1	ENSSTOP00000001138	ENSSTOP00000002077	ATP binding cassette subfamily A member 1.	Apolipoprotein A1.	0.963
ABCA1	CAV1	ENSSTOP00000001138	ENSSTOP00000015394	ATP binding cassette subfamily A member 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.410
ABCA1	NR1H2	ENSSTOP00000001138	ENSSTOP00000028032	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.897
ABCA1	NR1H3	ENSSTOP00000001138	ENSSTOP00000027881	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.867
ABCA1	PPARG	ENSSTOP00000001138	ENSSTOP00000011453	ATP binding cassette subfamily A member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.603
ABCA1	Pltp	ENSSTOP00000001138	ENSSTOP00000004557	ATP binding cassette subfamily A member 1.	BPI1 domain-containing protein.	0.444
ABCA12	APOA1	ENSSTOP00000015579	ENSSTOP00000002077	ATP binding cassette subfamily A member 12.	Apolipoprotein A1.	0.573
ABCA12	NR1H2	ENSSTOP00000015579	ENSSTOP00000028032	ATP binding cassette subfamily A member 12.	Nuclear receptor subfamily 1 group H member 2.	0.580
ABCA12	NR1H3	ENSSTOP00000015579	ENSSTOP00000027881	ATP binding cassette subfamily A member 12.	Nuclear receptor subfamily 1 group H member 3.	0.517
ABCA12	ZDHHC8	ENSSTOP00000015579	ENSSTOP00000020880	ATP binding cassette subfamily A member 12.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.460
ABCA3	ABCA1	ENSSTOP00000011846	ENSSTOP00000001138	ATP binding cassette subfamily A member 3.	ATP binding cassette subfamily A member 1.	0.539
ABCA3	APOA1	ENSSTOP00000011846	ENSSTOP00000002077	ATP binding cassette subfamily A member 3.	Apolipoprotein A1.	0.569
ABCA3	NR1H2	ENSSTOP00000011846	ENSSTOP00000028032	ATP binding cassette subfamily A member 3.	Nuclear receptor subfamily 1 group H member 2.	0.501
ABCA3	NR1H3	ENSSTOP00000011846	ENSSTOP00000027881	ATP binding cassette subfamily A member 3.	Nuclear receptor subfamily 1 group H member 3.	0.501
ABCA7	APOA1	ENSSTOP00000021012	ENSSTOP00000002077	ATP binding cassette subfamily A member 7.	Apolipoprotein A1.	0.898
ABCA7	NR1H2	ENSSTOP00000021012	ENSSTOP00000028032	ATP binding cassette subfamily A member 7.	Nuclear receptor subfamily 1 group H member 2.	0.501
ABCA7	NR1H3	ENSSTOP00000021012	ENSSTOP00000027881	ATP binding cassette subfamily A member 7.	Nuclear receptor subfamily 1 group H member 3.	0.501
ABCA7	TREM2	ENSSTOP00000021012	ENSSTOP00000009154	ATP binding cassette subfamily A member 7.	Triggering receptor expressed on myeloid cells 2.	0.410
ABCG1	APOA1	ENSSTOP00000016494	ENSSTOP00000002077	ATP binding cassette subfamily G member 1.	Apolipoprotein A1.	0.799