STRINGSTRING
CLCF1 CLCF1 IL34 IL34 ACY3 ACY3 ZNF488 ZNF488 PITX3 PITX3 BIN1 BIN1 NRG1 NRG1 NR2E1 NR2E1 ABCC8 ABCC8 FGFR3 FGFR3 DLX1 DLX1 TNF TNF LTA LTA HDAC2 HDAC2 PPARG PPARG RNF10 RNF10 Mycn Mycn Hdac1 Hdac1 TMEM98 TMEM98 DUSP10 DUSP10 ADCYAP1 ADCYAP1 ACTR3 ACTR3 PRMT5 PRMT5 TREM2 TREM2 Mag Mag TGFB1 TGFB1 GPR37L1 GPR37L1 SERPINE2 SERPINE2 Prkch Prkch PPP1CC PPP1CC ATOH1 ATOH1 SOX8 SOX8 LDLR LDLR CERS2 CERS2 EGFR EGFR ETV5 ETV5 NR1D1 NR1D1 CXCR4 CXCR4 LIF LIF DAB1 DAB1 F2 F2 IL6ST IL6ST I3M4W8_ICTTR I3M4W8_ICTTR RHEB RHEB Lin28a Lin28a EGR2 EGR2 TSPO TSPO E2F1 E2F1 IDH2 IDH2 VEGFC VEGFC IL1B IL1B LOC101959994 LOC101959994 ENPP2 ENPP2 Aspa Aspa FLT1 FLT1 NTF3 NTF3 NF2 NF2 LOC101960206 LOC101960206 DLX2 DLX2 BMP2 BMP2 LINGO1 LINGO1 ATXN1 ATXN1 LOC101955349 LOC101955349 HES1 HES1 Slc7a5 Slc7a5 PTPRZ1 PTPRZ1 CDKN2B CDKN2B SIRT2 SIRT2 PTPRA PTPRA ASCL2 ASCL2 Kdm4a Kdm4a PTN PTN HES5 HES5 ID2 ID2 TLR2 TLR2 GFAP GFAP TP73 TP73 Hmga2 Hmga2 LOC101975488 LOC101975488 DICER1 DICER1 TENM4 TENM4 ZNF365 ZNF365 UFL1 UFL1 IL33 IL33 ATF5 ATF5 ENSSTOP00000026011 ENSSTOP00000026011 MECP2 MECP2 ENSSTOP00000026639 ENSSTOP00000026639 NF1 NF1 MBD1 MBD1 NTRK3 NTRK3 DAG1 DAG1 DAAM2 DAAM2 I3N090_ICTTR I3N090_ICTTR GJC2 GJC2 RELA RELA BMP4 BMP4 RB1 RB1 DLL3 DLL3 NTN1 NTN1 RTN4 RTN4 RNF112 RNF112 SPINT1 SPINT1 LRP2 LRP2 EZH2 EZH2 LYN LYN IGF1 IGF1 MFN2 MFN2 ENSSTOP00000030319 ENSSTOP00000030319 SKI SKI PTK2 PTK2 ENSSTOP00000031278 ENSSTOP00000031278 PRPF19 PRPF19 MTOR MTOR SOX10 SOX10 GSX2 GSX2 DRD3 DRD3 I3MVL6_ICTTR I3MVL6_ICTTR MDK MDK SHH SHH TNFRSF1B TNFRSF1B CTNNB1 CTNNB1 SYNJ1 SYNJ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLCF1Cardiotrophin like cytokine factor 1. (219 aa)
IL34Interleukin 34. (240 aa)
ACY3Aminoacylase 3. (323 aa)
ZNF488Zinc finger protein 488. (325 aa)
PITX3Homeobox protein. (302 aa)
BIN1Bridging integrator 1. (609 aa)
NRG1Neuregulin 1. (700 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
ABCC8ATP binding cassette subfamily C member 8. (1624 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
DLX1Distal-less homeobox 1. (255 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RNF10Ring finger protein 10. (809 aa)
MycnBHLH domain-containing protein. (460 aa)
Hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (399 aa)
TMEM98Transmembrane protein 98. (226 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
MagUncharacterized protein. (64 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GPR37L1G protein-coupled receptor 37 like 1. (480 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
PrkchProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
SOX8SRY-box transcription factor 8. (466 aa)
LDLRLow density lipoprotein receptor. (863 aa)
CERS2Ceramide synthase 2. (380 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
ETV5ETS variant 5. (510 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
DAB1DAB adaptor protein 1. (555 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
Lin28aCCHC-type domain-containing protein. (210 aa)
EGR2Early growth response 2. (423 aa)
TSPOTranslocator protein. (169 aa)
E2F1E2F transcription factor 1. (392 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
LOC101959994Uncharacterized protein. (313 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
AspaUncharacterized protein. (313 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
NF2Neurofibromin 2. (596 aa)
LOC101960206Uncharacterized protein. (207 aa)
DLX2Distal-less homeobox 2. (329 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
ATXN1Ataxin 1. (792 aa)
LOC101955349BHLH domain-containing protein. (454 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
Slc7a5Uncharacterized protein. (448 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2277 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (813 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (190 aa)
Kdm4aUncharacterized protein. (1064 aa)
PTNPleiotrophin. (142 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (430 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
Hmga2Uncharacterized protein. (109 aa)
LOC101975488Uncharacterized protein. (456 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
TENM4Teneurin transmembrane protein 4. (2831 aa)
ZNF365Zinc finger protein 365. (407 aa)
UFL1UFM1 specific ligase 1. (792 aa)
IL33Interleukin 33. (264 aa)
ATF5Activating transcription factor 5. (206 aa)
ENSSTOP00000026011BHLH domain-containing protein. (102 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
ENSSTOP00000026639Hist_deacetyl domain-containing protein. (323 aa)
NF1Neurofibromin 1. (2473 aa)
MBD1Methyl-CpG binding domain protein 1. (626 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
DAG1Dystroglycan 1. (895 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1067 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (435 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
RB1RB transcriptional corepressor 1. (957 aa)
DLL3Delta like canonical Notch ligand 3. (585 aa)
NTN1Netrin 1. (596 aa)
RTN4Reticulon. (1177 aa)
RNF112Ring finger protein 112. (645 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (510 aa)
LRP2LDL receptor related protein 2. (4656 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
LYNTyrosine-protein kinase. (512 aa)
IGF1Insulin like growth factor 1. (166 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
ENSSTOP00000030319Uncharacterized protein. (2101 aa)
SKISKI proto-oncogene. (730 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
ENSSTOP00000031278CSP domain-containing protein. (186 aa)
PRPF19Pre-mRNA processing factor 19. (512 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SOX10SRY-box transcription factor 10. (466 aa)
GSX2GS homeobox 2. (218 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
MDKMidkine. (143 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
TNFRSF1BTNF receptor superfamily member 1B. (436 aa)
CTNNB1Catenin beta 1. (781 aa)
SYNJ1Synaptojanin 1. (1609 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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