STRINGSTRING
HDAC6 HDAC6 SRF SRF EDN2 EDN2 EXT1 EXT1 EIF2AK4 EIF2AK4 NLGN3 NLGN3 EPB41L5 EPB41L5 CTNNB1 CTNNB1 SEMA3F SEMA3F PRMT2 PRMT2 Flrt1 Flrt1 IMPACT IMPACT PLXNA1 PLXNA1 POU4F3 POU4F3 MEX3C MEX3C SLC9A6 SLC9A6 NDN NDN I3MW25_ICTTR I3MW25_ICTTR RNF6 RNF6 AGT AGT Nanog Nanog ADRA1A ADRA1A CSF1R CSF1R SEMA7A SEMA7A NRN1L NRN1L I3N055_ICTTR I3N055_ICTTR DCX DCX CDH4 CDH4 Ndel1 Ndel1 GDF9 GDF9 MAP2K4 MAP2K4 MAPT MAPT CADM1 CADM1 NIN NIN RARG RARG SHBG SHBG SOX9 SOX9 EDNRA EDNRA POU4F2 POU4F2 HSP90AB1 HSP90AB1 TMEM108 TMEM108 FOXL2 FOXL2 CAMK2D CAMK2D EMX1 EMX1 LOC101975245 LOC101975245 GSK3B GSK3B Gata4 Gata4 CYFIP1 CYFIP1 ULK2 ULK2 DCLK1 DCLK1 RYK RYK EDN1 EDN1 LHX2 LHX2 USP9X USP9X IST1 IST1 SPAG6 SPAG6 ARIH2 ARIH2 LAMB2 LAMB2 MAP1B MAP1B I3M023_ICTTR I3M023_ICTTR KDM1A KDM1A SEMA5A SEMA5A STK11 STK11 I3M249_ICTTR I3M249_ICTTR PLXNA3 PLXNA3 KMT2D KMT2D EFNA5 EFNA5 Wasf1 Wasf1 BCAN BCAN CDKL3 CDKL3 FLRT3 FLRT3 BDNF BDNF HSP90AA1 HSP90AA1 ITGA4 ITGA4 SEMA5B SEMA5B C9orf72 C9orf72 SLIT1 SLIT1 TNN TNN SLIT2 SLIT2 ENSSTOP00000032175 ENSSTOP00000032175 ENSSTOP00000031635 ENSSTOP00000031635 LLPH LLPH Nrn1 Nrn1 ENSSTOP00000031279 ENSSTOP00000031279 SORBS2 SORBS2 PAK6 PAK6 CYFIP2 CYFIP2 FUBP1 FUBP1 Akap13 Akap13 NRP2 NRP2 RAPH1 RAPH1 VCL VCL TNR TNR ZEB2 ZEB2 IQGAP1 IQGAP1 POSTN POSTN RND2 RND2 DDR1 DDR1 CPNE1 CPNE1 APP APP PDLIM5 PDLIM5 ALCAM ALCAM ENSSTOP00000026345 ENSSTOP00000026345 LOC101965498 LOC101965498 SIRT6 SIRT6 BIN3 BIN3 LOC101974646 LOC101974646 TGFBR2 TGFBR2 ULK1 ULK1 JADE2 JADE2 SMO SMO MYOCD MYOCD Aurka Aurka AGTR2 AGTR2 ST8SIA2 ST8SIA2 EDN3 EDN3 LIMK1 LIMK1 DVL1 DVL1 ITGB1 ITGB1 NRP1 NRP1 SLIT3 SLIT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC6Histone deacetylase 6. (1142 aa)
SRFSerum response factor. (505 aa)
EDN2Endothelin 2. (148 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
NLGN3Neuroligin 3. (848 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
CTNNB1Catenin beta 1. (781 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
Flrt1Fibronectin leucine rich transmembrane protein 1. (674 aa)
IMPACTImpact RWD domain protein. (297 aa)
PLXNA1Plexin A1. (1878 aa)
POU4F3POU domain protein. (338 aa)
MEX3CMex-3 RNA binding family member C. (556 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (677 aa)
NDNNecdin, MAGE family member. (325 aa)
I3MW25_ICTTRUncharacterized protein. (144 aa)
RNF6Ring finger protein 6. (683 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
NanogHomeobox domain-containing protein. (306 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
NRN1LNeuritin 1 like. (160 aa)
I3N055_ICTTRCobl domain-containing protein. (335 aa)
DCXDoublecortin. (360 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (864 aa)
Ndel1NUDE_C domain-containing protein. (345 aa)
GDF9Growth differentiation factor 9. (449 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
MAPTMicrotubule-associated protein. (430 aa)
CADM1Cell adhesion molecule 1. (477 aa)
NINNinein. (2136 aa)
RARGRetinoic acid receptor gamma. (458 aa)
SHBGSex hormone binding globulin. (405 aa)
SOX9SRY-box transcription factor 9. (509 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POU4F2POU domain protein. (410 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
TMEM108Transmembrane protein 108. (574 aa)
FOXL2Forkhead box L2. (368 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
EMX1Empty spiracles homeobox 1. (257 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
Gata4GATA-type domain-containing protein. (212 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
DCLK1Doublecortin like kinase 1. (761 aa)
RYKReceptor like tyrosine kinase. (475 aa)
EDN1Endothelin 1. (202 aa)
LHX2LIM homeobox 2. (406 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
IST1IST1 factor associated with ESCRT-III. (367 aa)
SPAG6Sperm associated antigen 6. (509 aa)
ARIH2RBR-type E3 ubiquitin transferase. (493 aa)
LAMB2Laminin subunit beta 2. (1846 aa)
MAP1BMicrotubule associated protein 1B. (2469 aa)
I3M023_ICTTRUncharacterized protein. (778 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (755 aa)
SEMA5ASemaphorin 5A. (1074 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
PLXNA3Plexin A3. (1872 aa)
KMT2DLysine methyltransferase 2D. (5449 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (186 aa)
Wasf1WH2 domain-containing protein. (559 aa)
BCANBrevican. (886 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
SEMA5BSemaphorin 5B. (1093 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
SLIT1Slit guidance ligand 1. (1525 aa)
TNNTenascin N. (1561 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
ENSSTOP00000032175Uncharacterized protein. (123 aa)
ENSSTOP00000031635Uncharacterized protein. (493 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (127 aa)
Nrn1Uncharacterized protein. (176 aa)
ENSSTOP00000031279Uncharacterized protein. (117 aa)
SORBS2Sorbin and SH3 domain containing 2. (1300 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
FUBP1Far upstream element binding protein 1. (658 aa)
Akap13Uncharacterized protein. (1423 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1331 aa)
VCLVinculin. (1134 aa)
TNRTenascin R. (1358 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1249 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
POSTNPeriostin. (836 aa)
RND2Rho family GTPase 2. (219 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (915 aa)
CPNE1Copine 1. (537 aa)
APPAmyloid beta precursor protein. (739 aa)
PDLIM5PDZ and LIM domain 5. (607 aa)
ALCAMActivated leukocyte cell adhesion molecule. (583 aa)
ENSSTOP00000026345Protein kinase domain-containing protein. (386 aa)
LOC101965498Uncharacterized protein. (325 aa)
SIRT6Sirtuin 6. (351 aa)
BIN3Bridging integrator 3. (253 aa)
LOC101974646NUDE_C domain-containing protein. (376 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
JADE2Jade family PHD finger 2. (830 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
MYOCDMyocardin. (894 aa)
AurkaProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (363 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (342 aa)
EDN3Endothelin 3. (197 aa)
LIMK1LIM domain kinase 1. (628 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SLIT3Slit guidance ligand 3. (1385 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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