STRINGSTRING
LRP5 LRP5 SMC3 SMC3 FGFR3 FGFR3 FANCC FANCC NR2E1 NR2E1 TFAP2C TFAP2C APC APC ENSSTOP00000031711 ENSSTOP00000031711 TCF7L2 TCF7L2 ENSSTOP00000031278 ENSSTOP00000031278 SKI SKI LDB1 LDB1 MTF2 MTF2 LOC101973262 LOC101973262 PRDM16 PRDM16 SETD6 SETD6 ENSSTOP00000029470 ENSSTOP00000029470 FZD7 FZD7 SMC5 SMC5 STAG2 STAG2 ENSSTOP00000028138 ENSSTOP00000028138 PCM1 PCM1 PROX1 PROX1 Arid1a Arid1a FGFR1 FGFR1 JAG1 JAG1 MED6 MED6 MED14 MED14 RBPJ RBPJ TBX3 TBX3 MED24 MED24 SMARCA4 SMARCA4 ENSSTOP00000024131 ENSSTOP00000024131 GNL3 GNL3 HESX1 HESX1 MED30 MED30 Lin28a Lin28a CREBBP CREBBP SMC1A SMC1A DIS3L2 DIS3L2 GATA2 GATA2 LIF LIF KDM4C KDM4C STAT3 STAT3 Tpt1 Tpt1 Rest Rest Med17 Med17 TRIM8 TRIM8 RTF1 RTF1 MED21 MED21 ELF5 ELF5 MED27 MED27 ASPM ASPM MED7 MED7 Foxo1 Foxo1 IGF2BP1 IGF2BP1 HOOK3 HOOK3 MED15 MED15 MAPK8 MAPK8 NODAL NODAL PHF19 PHF19 MMP24 MMP24 CTR9 CTR9 FAXC FAXC SRRT SRRT FANCD2 FANCD2 JMJD1C JMJD1C EIF4ENIF1 EIF4ENIF1 DDX6 DDX6 METTL14 METTL14 NIPBL NIPBL PAF1 PAF1 TUT4 TUT4 SS18 SS18 BMPR1A BMPR1A MED12 MED12 PIWIL2 PIWIL2 LSM1 LSM1 RIF1 RIF1 KLF10 KLF10 ZHX2 ZHX2 SFRP1 SFRP1 Nanos2 Nanos2 Pou5f1 Pou5f1 Nanog Nanog PELO PELO Fgf4 Fgf4 FGF10 FGF10 I3N0W3_ICTTR I3N0W3_ICTTR WNT9B WNT9B DLL1 DLL1 TCF7L1 TCF7L1 VPS72 VPS72 LOC101958853 LOC101958853 EOMES EOMES SALL4 SALL4 CDC73 CDC73 ZIC3 ZIC3 HES1 HES1 FUT10 FUT10 SIX2 SIX2 SPI1 SPI1 PRDM14 PRDM14 SOX9 SOX9 KAT6A KAT6A ASCL2 ASCL2 HES5 HES5 BCL9L BCL9L Foxo3 Foxo3 ESRRB ESRRB PRRX1 PRRX1 LEO1 LEO1 SALL1 SALL1 LIG4 LIG4 Hmga2 Hmga2 LDB2 LDB2 DICER1 DICER1 KIT KIT BCL9 BCL9 TET1 TET1 METTL3 METTL3 CDH2 CDH2 EIF4E EIF4E VANGL2 VANGL2 BRAF BRAF MCPH1 MCPH1 PADI4 PADI4 CUL4A CUL4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP5Uncharacterized protein. (1516 aa)
SMC3Structural maintenance of chromosomes 3. (995 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
TFAP2CTranscription factor AP-2 gamma. (419 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
ENSSTOP00000031711Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (143 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
ENSSTOP00000031278CSP domain-containing protein. (186 aa)
SKISKI proto-oncogene. (730 aa)
LDB1LIM domain binding 1. (411 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
LOC101973262TCTP domain-containing protein; Belongs to the TCTP family. (147 aa)
PRDM16PR/SET domain 16. (1127 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (519 aa)
ENSSTOP00000029470POU-specific domain-containing protein. (311 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
STAG2Stromal antigen 2. (1268 aa)
ENSSTOP00000028138Uncharacterized protein. (152 aa)
PCM1Pericentriolar material 1. (2117 aa)
PROX1Prospero homeobox 1. (737 aa)
Arid1aARID domain-containing protein. (1014 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (246 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
TBX3T-box transcription factor 3. (744 aa)
MED24Mediator complex subunit 24. (1008 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1646 aa)
ENSSTOP00000024131TCTP domain-containing protein; Belongs to the TCTP family. (161 aa)
GNL3G protein nucleolar 3. (546 aa)
HESX1HESX homeobox 1. (184 aa)
MED30Mediator complex subunit 30. (152 aa)
Lin28aCCHC-type domain-containing protein. (210 aa)
CREBBPCREB binding protein. (2410 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (872 aa)
GATA2GATA binding protein 2. (481 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
KDM4CLysine demethylase 4C. (1050 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
Tpt1Tumor protein, translationally-controlled 1; Belongs to the TCTP family. (172 aa)
RestUncharacterized protein. (328 aa)
Med17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
TRIM8Tripartite motif containing 8. (551 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
ELF5E74 like ETS transcription factor 5. (255 aa)
MED27Mediator complex subunit 27. (311 aa)
ASPMAbnormal spindle microtubule assembly. (3203 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
HOOK3Hook microtubule tethering protein 3. (718 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (785 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NODALNodal growth differentiation factor. (350 aa)
PHF19PHD finger protein 19. (583 aa)
MMP24Matrix metallopeptidase 24. (621 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1176 aa)
FAXCFailed axon connections homolog, metaxin like GST domain containing. (409 aa)
SRRTSerrate, RNA effector molecule. (872 aa)
FANCD2FA complementation group D2. (1276 aa)
JMJD1CJumonji domain containing 1C. (2532 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (967 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (458 aa)
NIPBLNipped-B protein. (2803 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (529 aa)
TUT4Terminal uridylyl transferase 4. (1661 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (412 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MED12Mediator complex subunit 12. (2146 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (962 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (82 aa)
RIF1Replication timing regulatory factor 1. (2480 aa)
KLF10Kruppel like factor 10. (480 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
Nanos2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (130 aa)
Pou5f1POU domain protein. (360 aa)
NanogHomeobox domain-containing protein. (306 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
I3N0W3_ICTTRBAF250_C domain-containing protein. (135 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
LOC101958853Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
EOMESEomesodermin. (702 aa)
SALL4Spalt like transcription factor 4. (610 aa)
CDC73Cell division cycle 73. (531 aa)
ZIC3Zic family member 3. (466 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
FUT10Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family. (481 aa)
SIX2SIX homeobox 2. (296 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
PRDM14PR/SET domain 14. (499 aa)
SOX9SRY-box transcription factor 9. (509 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2017 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (190 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
BCL9LBCL9 like. (1493 aa)
Foxo3Forkhead box O3. (673 aa)
ESRRBEstrogen related receptor beta. (454 aa)
PRRX1Paired related homeobox 1. (245 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
SALL1Spalt like transcription factor 1. (1313 aa)
LIG4DNA ligase. (911 aa)
Hmga2Uncharacterized protein. (109 aa)
LDB2LIM domain binding 2. (373 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
TET1Tet methylcytosine dioxygenase 1. (2077 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (920 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
VANGL2Vang-like protein. (547 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
MCPH1Microcephalin 1. (807 aa)
PADI4Peptidyl arginine deiminase 4. (637 aa)
CUL4ACullin 4A; Belongs to the cullin family. (671 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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