(43 nodes) Lipid storage network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LDAH	Lipid droplet associated hydrolase. (325 aa)
	CRY1	Cryptochrome circadian regulator 1. (609 aa)
	CIDEA	Cell death inducing DFFA like effector a. (171 aa)
	RNF213	Ring finger protein 213. (4892 aa)
	DYSF	Dysferlin. (2121 aa)
	SMIM22	Small integral membrane protein 22. (90 aa)
	Hexa	Beta-hexosaminidase. (527 aa)
	BSCL2	BSCL2 lipid droplet biogenesis associated, seipin. (462 aa)
	STARD4	StAR related lipid transfer domain containing 4. (222 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (443 aa)
	CDS2	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
	PNPLA2	Patatin like phospholipase domain containing 2. (489 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	AUP1	AUP1 lipid droplet regulating VLDL assembly factor. (440 aa)
	B4GALNT1	Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa)
	PLA2G4C	Phospholipase A2 group IVC. (571 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	APOA1	Apolipoprotein A1. (264 aa)
	ANGPTL3	Angiopoietin like 3. (455 aa)
	STAT5B	Signal transducer and activator of transcription. (765 aa)
	SOAT1	O-acyltransferase. (544 aa)
	STAT5A	Signal transducer and activator of transcription. (773 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	CRY2	Cryptochrome circadian regulator 2. (593 aa)
	ZFYVE1	Zinc finger FYVE-type containing 1. (777 aa)
	CDS1	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
	GBA	Glucosylceramidase. (516 aa)
	SQLE	Squalene epoxidase. (574 aa)
	HEXB	Beta-hexosaminidase. (538 aa)
	FITM1	Fat storage inducing transmembrane protein 1. (292 aa)
	TMEM159	Transmembrane protein 159. (161 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LRRN4CL	LRRN4 C-terminal like. (237 aa)
	FITM2	Fat storage inducing transmembrane protein 2. (262 aa)
	LOC101964870	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (327 aa)
	FFAR2	Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
	NRIP1	Nuclear receptor interacting protein 1. (1157 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (465 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (448 aa)
	GM2A	GM2 ganglioside activator. (192 aa)
	DGAT1	O-acyltransferase. (500 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (473 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	AUP1	ENSSTOP00000032180	ENSSTOP00000000941	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	AUP1 lipid droplet regulating VLDL assembly factor.	0.406
ANGPTL3	APOA1	ENSSTOP00000004549	ENSSTOP00000002077	Angiopoietin like 3.	Apolipoprotein A1.	0.434
APOA1	ANGPTL3	ENSSTOP00000002077	ENSSTOP00000004549	Apolipoprotein A1.	Angiopoietin like 3.	0.434
APOA1	CD36	ENSSTOP00000002077	ENSSTOP00000025792	Apolipoprotein A1.	CD36 molecule; Belongs to the CD36 family.	0.831
AUP1	ACVR1C	ENSSTOP00000000941	ENSSTOP00000032180	AUP1 lipid droplet regulating VLDL assembly factor.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.406
AUP1	CDS1	ENSSTOP00000000941	ENSSTOP00000008744	AUP1 lipid droplet regulating VLDL assembly factor.	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	0.617
AUP1	CDS2	ENSSTOP00000000941	ENSSTOP00000006029	AUP1 lipid droplet regulating VLDL assembly factor.	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	0.617
BSCL2	TMEM159	ENSSTOP00000031954	ENSSTOP00000006429	BSCL2 lipid droplet biogenesis associated, seipin.	Transmembrane protein 159.	0.418
CAV1	CD36	ENSSTOP00000015394	ENSSTOP00000025792	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	CD36 molecule; Belongs to the CD36 family.	0.454
CAV1	DYSF	ENSSTOP00000015394	ENSSTOP00000029130	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dysferlin.	0.529
CAV1	PLIN2	ENSSTOP00000015394	ENSSTOP00000032548	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Perilipin; Belongs to the perilipin family.	0.475
CAV1	PLIN3	ENSSTOP00000015394	ENSSTOP00000019914	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Perilipin; Belongs to the perilipin family.	0.469
CD36	APOA1	ENSSTOP00000025792	ENSSTOP00000002077	CD36 molecule; Belongs to the CD36 family.	Apolipoprotein A1.	0.831
CD36	CAV1	ENSSTOP00000025792	ENSSTOP00000015394	CD36 molecule; Belongs to the CD36 family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.454
CD36	DGAT1	ENSSTOP00000025792	ENSSTOP00000023501	CD36 molecule; Belongs to the CD36 family.	O-acyltransferase.	0.490
CD36	IL1B	ENSSTOP00000025792	ENSSTOP00000002047	CD36 molecule; Belongs to the CD36 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.425
CD36	PLIN2	ENSSTOP00000025792	ENSSTOP00000032548	CD36 molecule; Belongs to the CD36 family.	Perilipin; Belongs to the perilipin family.	0.598
CD36	PLIN3	ENSSTOP00000025792	ENSSTOP00000019914	CD36 molecule; Belongs to the CD36 family.	Perilipin; Belongs to the perilipin family.	0.512
CDS1	AUP1	ENSSTOP00000008744	ENSSTOP00000000941	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	AUP1 lipid droplet regulating VLDL assembly factor.	0.617
CDS1	CDS2	ENSSTOP00000008744	ENSSTOP00000006029	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	0.898