STRINGSTRING
GFRA4 GFRA4 Tob2 Tob2 Rflnb Rflnb ALOX5 ALOX5 CCR1 CCR1 SMAD7 SMAD7 TENT5A TENT5A MDK MDK ADRB2 ADRB2 BCL2 BCL2 SFRP1 SFRP1 CCN1 CCN1 BMP2K BMP2K ACVR2A ACVR2A BMP6 BMP6 BGLAP BGLAP ANO6 ANO6 BMP2 BMP2 LTBP3 LTBP3 CD276 CD276 PTGER4 PTGER4 OSR2 OSR2 FAM20C FAM20C KL KL P2RY2 P2RY2 PTPN11 PTPN11 PTH PTH CSF1 CSF1 TRPM4 TRPM4 SOST SOST LOC101967640 LOC101967640 SIX2 SIX2 WNT5A WNT5A BMPR1A BMPR1A MKX MKX ESRRA ESRRA SOX9 SOX9 PTN PTN GATA1 GATA1 FZD9 FZD9 GREM1 GREM1 ZMPSTE24 ZMPSTE24 TGFB3 TGFB3 PHOSPHO2 PHOSPHO2 MAPK14 MAPK14 GDF10 GDF10 COMP COMP ATRAID ATRAID RBPJ RBPJ LOC101961139 LOC101961139 PBX1 PBX1 TFAP2A TFAP2A SCUBE2 SCUBE2 KREMEN1 KREMEN1 SLC8A1 SLC8A1 LOC101974850 LOC101974850 INTU INTU ENSSTOP00000028967 ENSSTOP00000028967 RUNX2 RUNX2 PTK2B PTK2B MEF2C MEF2C LRP4 LRP4 DHRS3 DHRS3 ATP2B1 ATP2B1 OSR1 OSR1 SMURF1 SMURF1 LRP6 LRP6 SUV39H1 SUV39H1 OMD OMD BMPR1B BMPR1B LOC101967926 LOC101967926 NIPBL NIPBL ACVR2B ACVR2B MAPK1 MAPK1 MATN1 MATN1 ANKH ANKH ASXL2 ASXL2 DKK1 DKK1 BMP7 BMP7 CREB3L1 CREB3L1 NFE2 NFE2 CALCR CALCR DDR2 DDR2 SMAD3 SMAD3 KREMEN2 KREMEN2 TGFB1 TGFB1 P2RX7 P2RX7 ACTN3 ACTN3 AHSG AHSG CHSY1 CHSY1 ECM1 ECM1 FGF23 FGF23 NOTUM NOTUM RSAD2 RSAD2 THRB THRB Hif1a Hif1a ACVR1 ACVR1 WNT10B WNT10B EGR2 EGR2 CALCA CALCA FBN3 FBN3 ZBTB16 ZBTB16 TPH1 TPH1 GPM6B GPM6B BCOR BCOR TXLNG TXLNG BMPR2 BMPR2 SGMS2 SGMS2 TGFB2 TGFB2 CYP27B1 CYP27B1 BMP4 BMP4 MAPK3 MAPK3 WNT4 WNT4 SMAD6 SMAD6 FBN2 FBN2 P3H1 P3H1 PKDCC PKDCC VDR VDR NBR1 NBR1 ENSSTOP00000032440 ENSSTOP00000032440 FGFR3 FGFR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GFRA4GDNF family receptor alpha 4. (254 aa)
Tob2Uncharacterized protein. (345 aa)
RflnbUncharacterized protein. (208 aa)
ALOX5Arachidonate 5-lipoxygenase. (663 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TENT5ATerminal nucleotidyltransferase 5A. (447 aa)
MDKMidkine. (143 aa)
ADRB2Adrenoceptor beta 2. (416 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
CCN1Cellular communication network factor 1. (381 aa)
BMP2KBMP2 inducible kinase. (1130 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (95 aa)
ANO6Anoctamin. (884 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1193 aa)
CD276CD276 molecule. (316 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (580 aa)
KLKlotho. (1008 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
CSF1Colony stimulating factor 1. (497 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1173 aa)
SOSTSclerostin. (212 aa)
LOC101967640Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
SIX2SIX homeobox 2. (296 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MKXMohawk homeobox. (352 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
SOX9SRY-box transcription factor 9. (509 aa)
PTNPleiotrophin. (142 aa)
GATA1GATA binding protein 1. (413 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
GREM1Gremlin. (184 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (171 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
LOC101961139Anti_prolifrtn domain-containing protein. (290 aa)
PBX1PBX homeobox 1. (430 aa)
TFAP2ATranscription factor AP-2 alpha. (477 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (959 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (476 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
LOC101974850Uncharacterized protein. (190 aa)
INTUInturned planar cell polarity protein. (942 aa)
ENSSTOP00000028967Uncharacterized protein. (1864 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (520 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LRP4LDL receptor related protein 4. (1905 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SMURF1E3 ubiquitin-protein ligase. (753 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
OMDOsteomodulin. (424 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
LOC101967926Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
NIPBLNipped-B protein. (2803 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MATN1Matrilin 1. (496 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (492 aa)
ASXL2ASXL transcriptional regulator 2. (1435 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
NFE2Nuclear factor, erythroid 2. (374 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (497 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
AHSGAlpha 2-HS glycoprotein. (348 aa)
CHSY1Hexosyltransferase. (805 aa)
ECM1Extracellular matrix protein 1. (544 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (503 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (361 aa)
THRBThyroid hormone receptor beta. (476 aa)
Hif1aUncharacterized protein. (821 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
EGR2Early growth response 2. (423 aa)
CALCACalcitonin related polypeptide alpha. (137 aa)
FBN3Fibrillin 3. (2786 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
GPM6BGlycoprotein M6B. (328 aa)
BCORBCL6 corepressor. (1744 aa)
TXLNGTaxilin gamma. (523 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
FBN2Fibrillin 2. (2912 aa)
P3H1Prolyl 3-hydroxylase 1. (760 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (294 aa)
VDRVitamin D receptor. (423 aa)
NBR1NBR1 autophagy cargo receptor. (975 aa)
ENSSTOP00000032440G_PROTEIN_RECEP_F2_4 domain-containing protein. (318 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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