STRINGSTRING
Cfl1 Cfl1 P3H1 P3H1 RYK RYK CTH CTH SEMA3G SEMA3G RTN4 RTN4 ACVRL1 ACVRL1 ACVR1B ACVR1B FOXK1 FOXK1 SEMA6C SEMA6C NDUFS3 NDUFS3 FRZB FRZB NTN1 NTN1 GSK3A GSK3A SEMA4D SEMA4D RB1 RB1 SEMA4F SEMA4F CYP27B1 CYP27B1 TGFB2 TGFB2 DRAXIN DRAXIN TRIM40 TRIM40 SFRP2 SFRP2 BMPR2 BMPR2 SEMA5A SEMA5A STK11 STK11 NME6 NME6 RGS2 RGS2 RBBP7 RBBP7 SERTAD1 SERTAD1 CCDC85B CCDC85B PLXNA3 PLXNA3 DIP2B DIP2B C10orf90 C10orf90 EI24 EI24 CAPRIN2 CAPRIN2 MINAR1 MINAR1 PPT1 PPT1 DNAJC2 DNAJC2 SEMA3D SEMA3D SEMA4C SEMA4C SMARCA2 SMARCA2 TOMM70 TOMM70 RACK1 RACK1 DCUN1D3 DCUN1D3 TNK1 TNK1 CDKL3 CDKL3 NAIF1 NAIF1 RRAD RRAD ADAM15 ADAM15 TRIM46 TRIM46 SEMA4G SEMA4G SESN2 SESN2 TP53TG5 TP53TG5 SERPINE2 SERPINE2 TGFB1 TGFB1 Mag Mag SEMA4B SEMA4B CCN3 CCN3 SMAD3 SMAD3 SEMA5B SEMA5B SEMA3E SEMA3E BMP10 BMP10 IFRD1 IFRD1 SLIT1 SLIT1 ULK1 ULK1 ACTR3 ACTR3 CTDP1 CTDP1 SPHK2 SPHK2 CRLF3 CRLF3 FLCN FLCN HRG HRG PPARG PPARG PAK1 PAK1 Hspa1a Hspa1a CAV3 CAV3 NRP1 NRP1 PML PML CDKN2C CDKN2C SLIT3 SLIT3 Fgf13 Fgf13 ZC3H12D ZC3H12D DCBLD2 DCBLD2 SPART SPART OSGIN2 OSGIN2 SEMA6D SEMA6D ADIPOR1 ADIPOR1 CGREF1 CGREF1 CDA CDA GNG4 GNG4 PRDM4 PRDM4 SEMA3F SEMA3F HYAL1 HYAL1 SH3BP4 SH3BP4 CDKN1B CDKN1B SIRT1 SIRT1 EAF2 EAF2 Tchp Tchp NPPB NPPB BCL2 BCL2 OSTN OSTN SFRP1 SFRP1 SESN1 SESN1 Ppp1r9b Ppp1r9b RNF6 RNF6 SMAD4 SMAD4 AGT AGT WT1 WT1 SEMA7A SEMA7A Cdkn2d Cdkn2d GDF9 GDF9 FBP1 FBP1 ADIPOR2 ADIPOR2 Hspa1b Hspa1b NF2 NF2 OSGIN1 OSGIN1 DAB2IP DAB2IP RGS4 RGS4 PI16 PI16 CCR5 CCR5 CDKN1A CDKN1A GAS2L1 GAS2L1 MAP2 MAP2 TP53 TP53 I3N6Q6_ICTTR I3N6Q6_ICTTR G6PD G6PD WNT3 WNT3 CGRRF1 CGRRF1 WNT5A WNT5A WNT11 WNT11 IFRD2 IFRD2 I3NA52_ICTTR I3NA52_ICTTR WNT3A WNT3A DCSTAMP DCSTAMP NDUFA13 NDUFA13 I3NB69_ICTTR I3NB69_ICTTR CDKN2AIP CDKN2AIP SEMA6B SEMA6B GREM1 GREM1 SERTAD2 SERTAD2 RERG RERG Phb Phb Foxp1 Foxp1 SOX17 SOX17 MT3 MT3 TSPYL2 TSPYL2 I3NE23_ICTTR I3NE23_ICTTR GDF2 GDF2 MYL10 MYL10 FSTL4 FSTL4 PPARD PPARD RTN4R RTN4R Tro Tro ST7L ST7L LOC101963381 LOC101963381 SEMA6A SEMA6A SEMA3B SEMA3B SMARCA4 SMARCA4 MUL1 MUL1 ULK2 ULK2 BCL6 BCL6 LOC101962631 LOC101962631 Yy1 Yy1 CDHR2 CDHR2 MECP2 MECP2 PSRC1 PSRC1 ENSSTOP00000026660 ENSSTOP00000026660 CCAR2 CCAR2 HNF4A HNF4A PTPRS PTPRS HYAL2 HYAL2 DNAJB2 DNAJB2 TNR TNR PTPRJ PTPRJ EPHA7 EPHA7 PRDM11 PRDM11 FHL1 FHL1 KIAA0319 KIAA0319 SEMA3C SEMA3C IP6K2 IP6K2 LOC101960243 LOC101960243 Inhba Inhba VGLL4 VGLL4 SPAG9 SPAG9 BCL11A BCL11A MYL2 MYL2 SEMA4A SEMA4A RGMA RGMA ARHGAP4 ARHGAP4 DAB2 DAB2 CDK5 CDK5 CIRBP CIRBP SLIT2 SLIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
P3H1Prolyl 3-hydroxylase 1. (760 aa)
RYKReceptor like tyrosine kinase. (475 aa)
CTHCystathionine gamma-lyase. (405 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (773 aa)
RTN4Reticulon. (1177 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
FOXK1Forkhead box K1. (608 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (866 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (263 aa)
FRZBFrizzled related protein. (325 aa)
NTN1Netrin 1. (596 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (395 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (747 aa)
RB1RB transcriptional corepressor 1. (957 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (336 aa)
TRIM40Tripartite motif containing 40. (249 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SEMA5ASemaphorin 5A. (1074 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
NME6NME/NM23 nucleoside diphosphate kinase 6; Belongs to the NDK family. (115 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (425 aa)
SERTAD1SERTA domain containing 1. (236 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
PLXNA3Plexin A3. (1872 aa)
DIP2BDisco interacting protein 2 homolog B. (1576 aa)
C10orf90Chromosome 10 open reading frame 90. (790 aa)
EI24EI24 autophagy associated transmembrane protein. (326 aa)
CAPRIN2Caprin family member 2. (1205 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
PPT1Palmitoyl-protein thioesterase 1. (278 aa)
DNAJC2DnaJ heat shock protein family (Hsp40) member C2. (621 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (735 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (831 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1592 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
DCUN1D3DCN1-like protein. (304 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (662 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
NAIF1Nuclear apoptosis inducing factor 1. (327 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
ADAM15ADAM metallopeptidase domain 15. (837 aa)
TRIM46Tripartite motif containing 46. (759 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (839 aa)
SESN2Sestrin 2. (479 aa)
TP53TG5TP53 target 5. (236 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MagUncharacterized protein. (64 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (823 aa)
CCN3Cellular communication network factor 3. (350 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SEMA5BSemaphorin 5B. (1093 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (721 aa)
BMP10Bone morphogenetic protein 10. (422 aa)
IFRD1Interferon related developmental regulator 1. (449 aa)
SLIT1Slit guidance ligand 1. (1525 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (884 aa)
SPHK2Sphingosine kinase 2. (655 aa)
CRLF3Cytokine receptor like factor 3. (442 aa)
FLCNFolliculin. (579 aa)
HRGHistidine rich glycoprotein. (531 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
Hspa1aUncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PMLPromyelocytic leukemia. (877 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (170 aa)
SLIT3Slit guidance ligand 3. (1385 aa)
Fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (518 aa)
DCBLD2Discoidin, CUB and LCCL domain containing 2. (774 aa)
SPARTSpartin. (665 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (546 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1061 aa)
ADIPOR1Uncharacterized protein. (375 aa)
CGREF1Cell growth regulator with EF-hand domain 1. (305 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
HYAL1Hyaluronidase. (449 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SIRT1Sirtuin 1. (602 aa)
EAF2ELL associated factor 2. (263 aa)
TchpUncharacterized protein. (500 aa)
NPPBUncharacterized protein. (132 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
OSTNOsteocrin. (132 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SESN1Sestrin 1. (552 aa)
Ppp1r9bPDZ domain-containing protein. (361 aa)
RNF6Ring finger protein 6. (683 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
WT1WT1 transcription factor. (523 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
Cdkn2dANK_REP_REGION domain-containing protein. (166 aa)
GDF9Growth differentiation factor 9. (449 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
Hspa1bHeat shock protein family A (Hsp70) member 1B. (641 aa)
NF2Neurofibromin 2. (596 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (478 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (476 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (351 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
GAS2L1Growth arrest specific 2 like 1. (676 aa)
MAP2Microtubule-associated protein. (1878 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CGRRF1Cell growth regulator with ring finger domain 1. (332 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
IFRD2Interferon related developmental regulator 2. (440 aa)
I3NA52_ICTTRUncharacterized protein. (90 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (474 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
I3NB69_ICTTRUncharacterized protein. (166 aa)
CDKN2AIPCDKN2A interacting protein. (561 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (801 aa)
GREM1Gremlin. (184 aa)
SERTAD2SERTA domain containing 2. (307 aa)
RERGRAS like estrogen regulated growth inhibitor. (199 aa)
PhbProhibitin. (272 aa)
Foxp1Fork-head domain-containing protein. (674 aa)
SOX17SRY-box transcription factor 17. (415 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (584 aa)
I3NE23_ICTTRANK_REP_REGION domain-containing protein. (150 aa)
GDF2Growth differentiation factor 2. (429 aa)
MYL10Myosin light chain 10. (147 aa)
FSTL4Follistatin like 4. (760 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RTN4RReticulon 4 receptor. (473 aa)
TroMAGE domain-containing protein. (288 aa)
ST7LSuppression of tumorigenicity 7 like. (558 aa)
LOC101963381Prohibitin. (297 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (778 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1646 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
BCL6BCL6 transcription repressor. (706 aa)
LOC101962631Prohibitin. (247 aa)
Yy1Uncharacterized protein. (190 aa)
CDHR2Cadherin related family member 2. (1263 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
PSRC1Proline and serine rich coiled-coil 1. (326 aa)
ENSSTOP00000026660Uncharacterized protein. (178 aa)
CCAR2Cell cycle and apoptosis regulator 2. (920 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1855 aa)
HYAL2Hyaluronidase. (472 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (278 aa)
TNRTenascin R. (1358 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1197 aa)
EPHA7EPH receptor A7. (998 aa)
PRDM11PR/SET domain 11. (1177 aa)
FHL1Four and a half LIM domains 1. (323 aa)
KIAA0319KIAA0319. (901 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (448 aa)
LOC101960243Uncharacterized protein. (175 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
VGLL4Vestigial like family member 4. (283 aa)
SPAG9Sperm associated antigen 9. (1329 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (834 aa)
MYL2Myosin light chain 2. (166 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (758 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (450 aa)
ARHGAP4Rho GTPase activating protein 4. (940 aa)
DAB2DAB adaptor protein 2. (767 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CIRBPCold inducible RNA binding protein. (204 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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