STRINGSTRING
Slc33a1 Slc33a1 MSX2 MSX2 ACVRL1 ACVRL1 SMAD6 SMAD6 USP9X USP9X MEGF8 MEGF8 CCDC142 CCDC142 BMP4 BMP4 ROR2 ROR2 TGFB2 TGFB2 GDF3 GDF3 SFRP2 SFRP2 BMPR2 BMPR2 BMP5 BMP5 SOSTDC1 SOSTDC1 ECSIT ECSIT SMAD2 SMAD2 RGMB RGMB NOTCH2 NOTCH2 ACVR1 ACVR1 DLX5 DLX5 CHRDL1 CHRDL1 SMAD9 SMAD9 ID1 ID1 LOC101967701 LOC101967701 CHRD CHRD BMPER BMPER SMAD3 SMAD3 DLX3 DLX3 BMP10 BMP10 DSG4 DSG4 SMAD1 SMAD1 SMAD5 SMAD5 TMEM100 TMEM100 DDX5 DDX5 BMP7 BMP7 FAM83G FAM83G PPARG PPARG NODAL NODAL Etv2 Etv2 FST FST SMPD3 SMPD3 FKBP8 FKBP8 ATF2 ATF2 ACVR2B ACVR2B BMPR1B BMPR1B SMURF1 SMURF1 EXT1 EXT1 BMPR1A BMPR1A SLC39A5 SLC39A5 TWSG1 TWSG1 TGFBR3 TGFBR3 SMAD7 SMAD7 SFRP1 SFRP1 EGR1 EGR1 ZNF831 ZNF831 SMAD4 SMAD4 ACVR2A ACVR2A Nanog Nanog BMP6 BMP6 GDF9 GDF9 GDF6 GDF6 BMP2 BMP2 GDF7 GDF7 GDF15 GDF15 HES1 HES1 SOST SOST HES5 HES5 Zcchc12 Zcchc12 TGFB3 TGFB3 GDF2 GDF2 GDF5 GDF5 LOC101961346 LOC101961346 Gdf1 Gdf1 COMP COMP Zcchc18 Zcchc18 ENSSTOP00000026381 ENSSTOP00000026381 HIVEP1 HIVEP1 RUNX2 RUNX2 PDCD4 PDCD4 HJV HJV ENSSTOP00000030884 ENSSTOP00000030884 RGMA RGMA USP15 USP15 LOC101962293 LOC101962293 Bmp8b Bmp8b LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Slc33a1Solute carrier family 33 member 1. (550 aa)
MSX2Msh homeobox 2. (267 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
MEGF8Multiple EGF like domains 8. (2815 aa)
CCDC142Coiled-coil domain containing 142. (800 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (910 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GDF3Growth differentiation factor 3. (360 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
ECSITECSIT signalling integrator. (432 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (482 aa)
NOTCH2Notch receptor 2. (2364 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
DLX5Distal-less homeobox 5. (289 aa)
CHRDL1Chordin like 1. (447 aa)
SMAD9Mothers against decapentaplegic homolog. (452 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
LOC101967701TGF_BETA_2 domain-containing protein. (397 aa)
CHRDChordin. (898 aa)
BMPERBMP binding endothelial regulator. (685 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DLX3Distal-less homeobox 3. (287 aa)
BMP10Bone morphogenetic protein 10. (422 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1010 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TMEM100Transmembrane protein 100. (134 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FAM83GFamily with sequence similarity 83 member G. (820 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NODALNodal growth differentiation factor. (350 aa)
Etv2ETS domain-containing protein. (153 aa)
FSTFollistatin. (330 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FKBP8Peptidylprolyl isomerase. (374 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
SMURF1E3 ubiquitin-protein ligase. (753 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SLC39A5Solute carrier family 39 member 5. (538 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ZNF831Zinc finger protein 831. (1635 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
NanogHomeobox domain-containing protein. (306 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
GDF9Growth differentiation factor 9. (449 aa)
GDF6Growth differentiation factor 6. (460 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF7Growth differentiation factor 7. (445 aa)
GDF15Growth differentiation factor 15. (329 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SOSTSclerostin. (212 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
Zcchc12Uncharacterized protein. (401 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF5Growth differentiation factor 5. (495 aa)
LOC101961346Left-right determination factor. (363 aa)
Gdf1TGF_BETA_2 domain-containing protein. (373 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
Zcchc18Uncharacterized protein. (410 aa)
ENSSTOP00000026381Uncharacterized protein. (87 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2705 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (520 aa)
PDCD4Programmed cell death 4. (469 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
ENSSTOP00000030884TGF_BETA_2 domain-containing protein. (272 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (450 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
LOC101962293Left-right determination factor. (367 aa)
Bmp8bTGF_BETA_2 domain-containing protein. (252 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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