STRINGSTRING
Ppp1r9a Ppp1r9a ENSSTOP00000023976 ENSSTOP00000023976 CYFIP1 CYFIP1 FAM49A FAM49A CTTN CTTN Tmsb4x Tmsb4x CCL26 CCL26 ICAM1 ICAM1 SPTAN1 SPTAN1 SPTBN2 SPTBN2 PAK3 PAK3 ARPC3 ARPC3 TWF1 TWF1 EVL EVL ARPC4 ARPC4 ADD1 ADD1 ENSSTOP00000028287 ENSSTOP00000028287 BBS4 BBS4 MYO1C MYO1C FLII FLII FCHSD2 FCHSD2 TENM1 TENM1 DBN1 DBN1 ADD3 ADD3 CAPN1 CAPN1 Cfl1 Cfl1 ENSSTOP00000029646 ENSSTOP00000029646 MLST8 MLST8 KANK1 KANK1 CYFIP2 CYFIP2 Tmsb15b Tmsb15b PTK2B PTK2B EPS8 EPS8 CAPZB CAPZB SSH3 SSH3 LOC101975760 LOC101975760 MTOR MTOR BAIAP2 BAIAP2 BIN1 BIN1 ARPC5 ARPC5 SLIT2 SLIT2 AVIL AVIL I3LYR0_ICTTR I3LYR0_ICTTR Arpc1a Arpc1a ARPC1B ARPC1B NCK1 NCK1 DAAM2 DAAM2 Pik3r2 Pik3r2 HAX1 HAX1 MKKS MKKS FAM49B FAM49B CDC42EP3 CDC42EP3 LATS1 LATS1 PYCARD PYCARD CARMIL1 CARMIL1 MYADM MYADM GRB2 GRB2 PRKCE PRKCE SSH1 SSH1 SCIN SCIN ACTR3 ACTR3 CAPZA3 CAPZA3 PFN2 PFN2 ARHGAP28 ARHGAP28 SNX9 SNX9 SPTB SPTB HCLS1 HCLS1 CAPG CAPG ARHGAP18 ARHGAP18 CORO1A CORO1A MTPN MTPN ARPC5L ARPC5L ARFGEF1 ARFGEF1 MAP3K1 MAP3K1 BAG4 BAG4 RAC1 RAC1 SPTBN1 SPTBN1 RICTOR RICTOR GSN GSN GBA2 GBA2 CSF3 CSF3 CCL24 CCL24 PRKCD PRKCD RDX RDX PFN4 PFN4 TMOD1 TMOD1 DBNL DBNL Tmsb10 Tmsb10 NCKAP1 NCKAP1 KANK3 KANK3 BAIAP2L2 BAIAP2L2 Cdc42ep5 Cdc42ep5 LMOD3 LMOD3 TLR2 TLR2 Cracd Cracd BAIAP2L1 BAIAP2L1 ARF6 ARF6 SVIL SVIL ABITRAM ABITRAM PFN1 PFN1 CAPZA2 CAPZA2 PLEKHG2 PLEKHG2 COTL1 COTL1 I3N6Q6_ICTTR I3N6Q6_ICTTR ALOX15 ALOX15 MPHOSPH8 MPHOSPH8 LOC101973767 LOC101973767 CDC42EP4 CDC42EP4 CCL21 CCL21 HIP1R HIP1R PECAM1 PECAM1 FHOD3 FHOD3 NCKAP1L NCKAP1L LMOD1 LMOD1 LOC101976085 LOC101976085 LMOD2 LMOD2 PFN3 PFN3 TMOD3 TMOD3 Sptbn4 Sptbn4 SSH2 SSH2 WASHC1 WASHC1 VIL1 VIL1 KIRREL1 KIRREL1 CARMIL2 CARMIL2 ESAM ESAM FCHSD1 FCHSD1 Capza1 Capza1 NPHS1 NPHS1 SPTA1 SPTA1 ARPC2 ARPC2 TMOD4 TMOD4 RASA1 RASA1 FER FER ADD2 ADD2 NCK2 NCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ppp1r9aUncharacterized protein. (446 aa)
ENSSTOP00000023976Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (151 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
FAM49AFamily with sequence similarity 49 member A. (323 aa)
CTTNCortactin. (549 aa)
Tmsb4xThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
CCL26C-C motif chemokine. (91 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
ARPC3Actin related protein 2/3 complex subunit 3. (102 aa)
TWF1Twinfilin actin binding protein 1. (357 aa)
EVLEnah/Vasp-like; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (421 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (176 aa)
ADD1Adducin 1. (764 aa)
ENSSTOP00000028287F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (267 aa)
BBS4Bardet-Biedl syndrome 4. (514 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1094 aa)
FLIIFLII actin remodeling protein. (1306 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
DBN1Drebrin 1. (679 aa)
ADD3Adducin 3. (706 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (743 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
ENSSTOP00000029646WH1 domain-containing protein. (363 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
KANK1KN motif and ankyrin repeat domains 1. (1361 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
Tmsb15bThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (839 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
SSH3Slingshot protein phosphatase 3. (648 aa)
LOC101975760F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (233 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
BIN1Bridging integrator 1. (609 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
AVILAdvillin. (819 aa)
I3LYR0_ICTTRUncharacterized protein. (381 aa)
Arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
NCK1Cytoplasmic protein. (377 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1067 aa)
Pik3r2Uncharacterized protein. (724 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (253 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
PYCARDPYD and CARD domain containing. (194 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1387 aa)
MYADMMyeloid associated differentiation marker. (321 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
SSH1Slingshot protein phosphatase 1. (1016 aa)
SCINScinderin. (715 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
ARHGAP28Rho GTPase activating protein 28. (706 aa)
SNX9Sorting nexin. (610 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2326 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (478 aa)
CAPGCapping actin protein, gelsolin like. (349 aa)
ARHGAP18Rho GTPase activating protein 18. (661 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
MTPNMyotrophin. (118 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1437 aa)
BAG4BCL2 associated athanogene 4. (324 aa)
RAC1Rac family small GTPase 1. (211 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1660 aa)
GSNGelsolin. (748 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (919 aa)
CSF3Colony stimulating factor 3. (210 aa)
CCL24C-C motif chemokine. (119 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
RDXRadixin. (583 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
TMOD1Tropomodulin 1. (359 aa)
DBNLDrebrin like. (433 aa)
Tmsb10Uncharacterized protein. (58 aa)
NCKAP1NCK associated protein 1. (1132 aa)
KANK3KN motif and ankyrin repeat domains 3. (818 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (460 aa)
Cdc42ep5CRIB domain-containing protein. (79 aa)
LMOD3Leiomodin 3. (570 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
CracdUncharacterized protein. (246 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (492 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SVILSupervillin. (2287 aa)
ABITRAMActin binding transcription modulator. (179 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (287 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1390 aa)
COTL1Coactosin like F-actin binding protein 1. (131 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
MPHOSPH8M-phase phosphoprotein 8. (867 aa)
LOC101973767WH1 domain-containing protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
CDC42EP4CDC42 effector protein 4. (347 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
HIP1RHuntingtin interacting protein 1 related. (1037 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (740 aa)
FHOD3Formin homology 2 domain containing 3. (1549 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
LMOD1Leiomodin 1. (602 aa)
LOC101976085Profilin; Belongs to the profilin family. (153 aa)
LMOD2Leiomodin 2. (553 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
TMOD3Tropomodulin 3. (352 aa)
Sptbn4Spectrin beta, non-erythrocytic 4. (2570 aa)
SSH2Slingshot protein phosphatase 2. (1423 aa)
WASHC1WASH complex subunit 1. (471 aa)
VIL1Villin 1. (827 aa)
KIRREL1Kirre like nephrin family adhesion molecule 1. (769 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1403 aa)
ESAMEndothelial cell adhesion molecule. (393 aa)
FCHSD1FCH and double SH3 domains 1. (688 aa)
Capza1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1140 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2417 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
TMOD4Tropomodulin 4. (345 aa)
RASA1RAS p21 protein activator 1. (1030 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ADD2Adducin 2. (724 aa)
NCK2Cytoplasmic protein. (380 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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