(45 nodes) Negative regulation of epithelial cell differentiation network (Ictidomys tridecemlineatus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	Notch4	Uncharacterized protein. (1955 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (411 aa)
	Spry2	Uncharacterized protein. (315 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1123 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	FOXP4	Forkhead box P4. (666 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (342 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (151 aa)
	MMP9	Matrix metallopeptidase 9. (667 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (445 aa)
	LOC101973790	Uncharacterized protein. (311 aa)
	GDF3	Growth differentiation factor 3. (360 aa)
	GRHL2	Grainyhead like transcription factor 2. (607 aa)
	FRZB	Frizzled related protein. (325 aa)
	VHL	Von Hippel-Lindau tumor suppressor. (182 aa)
	MSX2	Msh homeobox 2. (267 aa)
	CCND1	Cyclin D1. (250 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
	FST	Follistatin. (330 aa)
	NODAL	Nodal growth differentiation factor. (350 aa)
	Nkx6-3	Homeobox domain-containing protein. (263 aa)
	XDH	Xanthine dehydrogenase. (1300 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	HOXA7	Homeobox A7. (232 aa)
	FOXJ2	Forkhead box J2. (574 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (430 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	TBX3	T-box transcription factor 3. (744 aa)
	FOXE3	Forkhead box E3. (228 aa)
	SALL1	Spalt like transcription factor 1. (1313 aa)
	Foxp1	Fork-head domain-containing protein. (674 aa)
	HES5	Hes family bHLH transcription factor 5. (141 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	SIX2	SIX homeobox 2. (296 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (315 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	GDF3	ENSSTOP00000000427	ENSSTOP00000001634	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 3.	0.666
ACVRL1	NODAL	ENSSTOP00000000427	ENSSTOP00000011597	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.730
ACVRL1	TGFBR1	ENSSTOP00000000427	ENSSTOP00000012159	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.806
CAV1	CTNNB1	ENSSTOP00000015394	ENSSTOP00000014441	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.789
CAV1	SPRED1	ENSSTOP00000015394	ENSSTOP00000005209	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 1.	0.445
CAV1	SPRED2	ENSSTOP00000015394	ENSSTOP00000031425	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 2.	0.422
CAV1	TGFBR1	ENSSTOP00000015394	ENSSTOP00000012159	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.408
CCND1	CTNNB1	ENSSTOP00000000365	ENSSTOP00000014441	Cyclin D1.	Catenin beta 1.	0.708
CCND1	JAG1	ENSSTOP00000000365	ENSSTOP00000026569	Cyclin D1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.434
CCND1	MMP9	ENSSTOP00000000365	ENSSTOP00000005706	Cyclin D1.	Matrix metallopeptidase 9.	0.504
CITED1	SIX2	ENSSTOP00000007553	ENSSTOP00000020637	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	SIX homeobox 2.	0.414
CTNNB1	CAV1	ENSSTOP00000014441	ENSSTOP00000015394	Catenin beta 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.789
CTNNB1	CCND1	ENSSTOP00000014441	ENSSTOP00000000365	Catenin beta 1.	Cyclin D1.	0.708
CTNNB1	DLL1	ENSSTOP00000014441	ENSSTOP00000018225	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.540
CTNNB1	EZH2	ENSSTOP00000014441	ENSSTOP00000029493	Catenin beta 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.746
CTNNB1	FRZB	ENSSTOP00000014441	ENSSTOP00000000615	Catenin beta 1.	Frizzled related protein.	0.520
CTNNB1	JAG1	ENSSTOP00000014441	ENSSTOP00000026569	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.518
CTNNB1	MMP9	ENSSTOP00000014441	ENSSTOP00000005706	Catenin beta 1.	Matrix metallopeptidase 9.	0.504
CTNNB1	SMO	ENSSTOP00000014441	ENSSTOP00000010265	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.512
CTNNB1	SOX9	ENSSTOP00000014441	ENSSTOP00000021123	Catenin beta 1.	SRY-box transcription factor 9.	0.843