STRINGSTRING
MESP1 MESP1 NCOA3 NCOA3 NUMA1 NUMA1 PROM1 PROM1 ZEB2 ZEB2 PAX8 PAX8 LOC101962934 LOC101962934 ENSSTOP00000025794 ENSSTOP00000025794 ETV4 ETV4 ENSSTOP00000024694 ENSSTOP00000024694 GDF2 GDF2 LOC101968601 LOC101968601 VDR VDR PTCH1 PTCH1 FOXN1 FOXN1 FOXJ1 FOXJ1 FOXA3 FOXA3 Fgf2 Fgf2 SULT2B1 SULT2B1 CTNNB1 CTNNB1 KDF1 KDF1 SFN SFN MACROH2A1 MACROH2A1 Etv2 Etv2 MACROH2A2 MACROH2A2 BMP7 BMP7 SFRP4 SFRP4 TMEM100 TMEM100 PAX2 PAX2 Prkch Prkch ATOH1 ATOH1 BAD BAD WNT9A WNT9A AHI1 AHI1 RFX3 RFX3 ATOH8 ATOH8 PTCH2 PTCH2 LIF LIF WNT10B WNT10B PAX6 PAX6 ALOX15B ALOX15B PAX4 PAX4 CYP27B1 CYP27B1 BMP4 BMP4 SERPINE1 SERPINE1 ACVRL1 ACVRL1 VEZF1 VEZF1 Trim16 Trim16 OVOL2 OVOL2 MED1 MED1 BMP6 BMP6 LHX1 LHX1 TP73 TP73 SOX9 SOX9 CDKN2B CDKN2B COMMD5 COMMD5 GDNF GDNF BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MESP1Mesoderm posterior bHLH transcription factor 1. (246 aa)
NCOA3Nuclear receptor coactivator. (1413 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2106 aa)
PROM1Prominin 1. (896 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1249 aa)
PAX8Paired box 8. (574 aa)
LOC101962934Anti_prolifrtn domain-containing protein. (137 aa)
ENSSTOP00000025794Uncharacterized protein. (78 aa)
ETV4ETS variant 4. (486 aa)
ENSSTOP00000024694Uncharacterized protein. (158 aa)
GDF2Growth differentiation factor 2. (429 aa)
LOC101968601Uncharacterized protein. (80 aa)
VDRVitamin D receptor. (423 aa)
PTCH1Patched 1. (1450 aa)
FOXN1Forkhead box N1. (648 aa)
FOXJ1Forkhead box J1. (421 aa)
FOXA3Forkhead box A3. (349 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (340 aa)
CTNNB1Catenin beta 1. (781 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
Etv2ETS domain-containing protein. (153 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SFRP4Secreted frizzled related protein 4. (347 aa)
TMEM100Transmembrane protein 100. (134 aa)
PAX2Paired box 2. (417 aa)
PrkchProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
BADBCL2 associated agonist of cell death. (208 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
AHI1Abelson helper integration site 1. (1050 aa)
RFX3Regulatory factor X3. (749 aa)
ATOH8Atonal bHLH transcription factor 8. (322 aa)
PTCH2Patched 2. (1197 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PAX6Paired box 6. (436 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (678 aa)
PAX4Paired box 4. (350 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
VEZF1Vascular endothelial zinc finger 1. (514 aa)
Trim16Uncharacterized protein. (558 aa)
OVOL2Ovo like zinc finger 2. (276 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
LHX1LIM homeobox 1. (406 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
COMMD5COMM domain containing 5. (224 aa)
GDNFGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (212 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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