(40 nodes) Endocrine pancreas development network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDPK1	3-phosphoinositide dependent protein kinase 1. (556 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	PAX4	Paired box 4. (350 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (920 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	PAX6	Paired box 6. (436 aa)
	GIP	Gastric inhibitory polypeptide. (140 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)
	NKX6-2	NK6 homeobox 2. (267 aa)
	RFX3	Regulatory factor X3. (749 aa)
	IL6R	Interleukin 6 receptor. (409 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	RFX6	Regulatory factor X6. (928 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	NKX6-1	NK6 homeobox 1. (366 aa)
	VHL	Von Hippel-Lindau tumor suppressor. (182 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	PDE3B	Phosphodiesterase. (1046 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	ZBED6	Zinc finger BED-type containing 6. (979 aa)
	BMP6	Bone morphogenetic protein 6. (507 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
	LOC101960206	Uncharacterized protein. (207 aa)
	GATA6	GATA binding protein 6. (593 aa)
	NEUROG3	Neurogenin 3. (215 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	FOXA2	Forkhead box A2. (463 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	ANXA1	Annexin. (346 aa)
	ONECUT1	One cut domain family member. (465 aa)
	GDF11	Growth differentiation factor 11. (387 aa)
	MYT1	Myelin transcription factor 1. (1148 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	MEN1	Menin 1. (616 aa)
	BAK1	BCL2 antagonist/killer 1. (208 aa)
	SIDT2	SID1 transmembrane family member 2. (853 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP5	ENSSTOP00000001023	ENSSTOP00000002171	Bone morphogenetic protein 4.	Bone morphogenetic protein 5.	0.788
BMP4	BMP6	ENSSTOP00000001023	ENSSTOP00000017540	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.919
BMP4	GATA6	ENSSTOP00000001023	ENSSTOP00000018653	Bone morphogenetic protein 4.	GATA binding protein 6.	0.492
BMP4	SMO	ENSSTOP00000001023	ENSSTOP00000010265	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.408
BMP4	WNT5A	ENSSTOP00000001023	ENSSTOP00000020681	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.434
BMP5	BMP4	ENSSTOP00000002171	ENSSTOP00000001023	Bone morphogenetic protein 5.	Bone morphogenetic protein 4.	0.788
BMP6	BMP4	ENSSTOP00000017540	ENSSTOP00000001023	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.919
DLL1	HES1	ENSSTOP00000018225	ENSSTOP00000020051	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.522
FOXA2	GATA6	ENSSTOP00000020242	ENSSTOP00000018653	Forkhead box A2.	GATA binding protein 6.	0.757
FOXA2	HNF4A	ENSSTOP00000020242	ENSSTOP00000027193	Forkhead box A2.	Hepatocyte nuclear factor 4 alpha.	0.547
FOXA2	ONECUT1	ENSSTOP00000020242	ENSSTOP00000021930	Forkhead box A2.	One cut domain family member.	0.510
FOXA2	PAX6	ENSSTOP00000020242	ENSSTOP00000002864	Forkhead box A2.	Paired box 6.	0.603
GATA6	BMP4	ENSSTOP00000018653	ENSSTOP00000001023	GATA binding protein 6.	Bone morphogenetic protein 4.	0.492
GATA6	FOXA2	ENSSTOP00000018653	ENSSTOP00000020242	GATA binding protein 6.	Forkhead box A2.	0.757
GATA6	HNF4A	ENSSTOP00000018653	ENSSTOP00000027193	GATA binding protein 6.	Hepatocyte nuclear factor 4 alpha.	0.440
GATA6	SOX9	ENSSTOP00000018653	ENSSTOP00000021123	GATA binding protein 6.	SRY-box transcription factor 9.	0.650
GIP	PAX4	ENSSTOP00000003611	ENSSTOP00000001895	Gastric inhibitory polypeptide.	Paired box 4.	0.422
GIP	PAX6	ENSSTOP00000003611	ENSSTOP00000002864	Gastric inhibitory polypeptide.	Paired box 6.	0.501
HES1	DLL1	ENSSTOP00000020051	ENSSTOP00000018225	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.522
HES1	NEUROD1	ENSSTOP00000020051	ENSSTOP00000019657	Hes family bHLH transcription factor 1.	Neurogenic differentiation factor.	0.542