STRINGSTRING
TPCN1 TPCN1 ATP7A ATP7A EPHA4 EPHA4 SORL1 SORL1 WDR91 WDR91 DOP1B DOP1B MMGT1 MMGT1 I3M6L1_ICTTR I3M6L1_ICTTR VAMP8 VAMP8 SNX21 SNX21 PI4K2A PI4K2A EGFR EGFR RAC1 RAC1 SNX3 SNX3 NTRK1 NTRK1 DNAJC13 DNAJC13 WLS WLS OR51E2 OR51E2 Snx4 Snx4 BOK BOK SNX8 SNX8 LITAF LITAF SLC1A1 SLC1A1 ABCA7 ABCA7 RAB14 RAB14 ANXA1 ANXA1 HPS6 HPS6 PDLIM4 PDLIM4 NAPEPLD NAPEPLD SPHK1 SPHK1 TMEM184A TMEM184A SORCS2 SORCS2 STAM STAM ARC ARC ARF6 ARF6 SNX19 SNX19 RAB5A RAB5A CLCN4 CLCN4 PSEN1 PSEN1 SNX2 SNX2 ENSSTOP00000025451 ENSSTOP00000025451 NSG1 NSG1 PLD3 PLD3 ENSSTOP00000026262 ENSSTOP00000026262 Cln3 Cln3 SNX20 SNX20 LOC101958063 LOC101958063 TMEM30A TMEM30A DAGLA DAGLA NSG2 NSG2 SNX12 SNX12 VPS41 VPS41 GGA3 GGA3 GRIPAP1 GRIPAP1 KIAA0319 KIAA0319 PIKFYVE PIKFYVE CLCN3 CLCN3 OSBPL6 OSBPL6 SNX1 SNX1 ZFYVE9 ZFYVE9 ENSSTOP00000029018 ENSSTOP00000029018 EPHA8 EPHA8 MARCHF1 MARCHF1 MARCHF3 MARCHF3 SNX27 SNX27 ATP9A ATP9A GGA2 GGA2 Lamp3 Lamp3 ATP13A3 ATP13A3 EHD1 EHD1 STEAP4 STEAP4 CLIP3 CLIP3 NTRK2 NTRK2 GRIA1 GRIA1 SH3GL1 SH3GL1 GPNMB GPNMB CLVS2 CLVS2 HGS HGS LDLRAD4 LDLRAD4 VTI1B VTI1B LAMP5 LAMP5 RCC2 RCC2 MR1 MR1 PMEPA1 PMEPA1 INPP5B INPP5B TMEM165 TMEM165 WASHC1 WASHC1 STAM2 STAM2 CMTM6 CMTM6 CLVS1 CLVS1 ZFYVE28 ZFYVE28 KCNH1 KCNH1 SLC9A6 SLC9A6 SYNDIG1 SYNDIG1 LOC101976737 LOC101976737 PLPP2 PLPP2 ATP13A4 ATP13A4 MON2 MON2 INPP4A INPP4A Rep15 Rep15 RAB21 RAB21 ABCB6 ABCB6 STX7 STX7 RAB4A RAB4A SNX16 SNX16 NEU3 NEU3 WDR81 WDR81 Tsg101 Tsg101 STX12 STX12 I3N4W4_ICTTR I3N4W4_ICTTR SH3GL3 SH3GL3 GGA1 GGA1 PLA2G4E PLA2G4E APPL2 APPL2 EPHB1 EPHB1 UBXN6 UBXN6 LLGL1 LLGL1 APPL1 APPL1 SNX5 SNX5 OCRL OCRL PI4K2B PI4K2B VPS16 VPS16 ATP11B ATP11B Vps33b Vps33b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPCN1Two pore segment channel 1. (815 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
EPHA4EPH receptor A4. (986 aa)
SORL1Sortilin related receptor 1. (2199 aa)
WDR91WD repeat domain 91. (746 aa)
DOP1BDOP1 leucine zipper like protein B. (2290 aa)
MMGT1Membrane magnesium transporter 1. (127 aa)
I3M6L1_ICTTRABC transmembrane type-1 domain-containing protein. (528 aa)
VAMP8Vesicle associated membrane protein 8. (141 aa)
SNX21Sorting nexin family member 21. (364 aa)
PI4K2API3K/PI4K domain-containing protein. (479 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
RAC1Rac family small GTPase 1. (211 aa)
SNX3Sorting nexin 3. (162 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2177 aa)
WLSWnt ligand secretion mediator. (541 aa)
OR51E2Olfactory receptor. (320 aa)
Snx4Uncharacterized protein. (165 aa)
BOKBCL2 family apoptosis regulator BOK. (173 aa)
SNX8Sorting nexin 8. (455 aa)
LITAFLipopolysaccharide induced TNF factor. (167 aa)
SLC1A1Amino acid transporter. (523 aa)
ABCA7ATP binding cassette subfamily A member 7. (2098 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
ANXA1Annexin. (346 aa)
HPS6Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (806 aa)
PDLIM4PDZ and LIM domain 4. (331 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (400 aa)
SPHK1Sphingosine kinase 1. (385 aa)
TMEM184ATransmembrane protein 184A. (448 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1046 aa)
STAMSignal transducing adaptor molecule. (535 aa)
ARCActivity regulated cytoskeleton associated protein. (391 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SNX19Sorting nexin 19. (997 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
CLCN4Chloride channel protein. (747 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SNX2Sorting nexin 2. (523 aa)
ENSSTOP00000025451MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (212 aa)
NSG1Neuronal vesicle trafficking associated 1. (185 aa)
PLD3Phospholipase D family member 3. (520 aa)
ENSSTOP00000026262Ig-like domain-containing protein; Belongs to the MHC class I family. (423 aa)
Cln3Battenin. (466 aa)
SNX20Sorting nexin 20. (318 aa)
LOC101958063CAP-ZIP_m domain-containing protein. (1334 aa)
TMEM30ACell cycle control protein; Belongs to the CDC50/LEM3 family. (346 aa)
DAGLADiacylglycerol lipase alpha. (1042 aa)
NSG2Neuronal vesicle trafficking associated 2. (171 aa)
SNX12Sorting nexin 12. (163 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (728 aa)
GRIPAP1GRIP1 associated protein 1. (841 aa)
KIAA0319KIAA0319. (901 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (1999 aa)
CLCN3Chloride channel protein. (866 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (967 aa)
SNX1Sorting nexin 1. (529 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
ENSSTOP00000029018UEV domain-containing protein. (97 aa)
EPHA8EPH receptor A8. (1006 aa)
MARCHF1Membrane associated ring-CH-type finger 1. (533 aa)
MARCHF3Membrane associated ring-CH-type finger 3. (253 aa)
SNX27Sorting nexin 27. (542 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (986 aa)
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (609 aa)
Lamp3Uncharacterized protein. (413 aa)
ATP13A3ATPase 13A3. (1017 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (551 aa)
STEAP4STEAP4 metalloreductase. (470 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
NTRK2Tyrosine-protein kinase receptor. (821 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (837 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
GPNMBGlycoprotein nmb. (556 aa)
CLVS2Clavesin 2. (327 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
LAMP5Lysosomal associated membrane protein family member 5. (264 aa)
RCC2Regulator of chromosome condensation 2. (427 aa)
MR1Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (343 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (264 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (994 aa)
TMEM165GDT1 family protein. (322 aa)
WASHC1WASH complex subunit 1. (471 aa)
STAM2Signal transducing adaptor molecule 2. (524 aa)
CMTM6CKLF like MARVEL transmembrane domain containing 6. (183 aa)
CLVS1Clavesin 1. (354 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (910 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1. (962 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (677 aa)
SYNDIG1Synapse differentiation inducing 1. (258 aa)
LOC101976737FYVE-type domain-containing protein. (1544 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
ATP13A4Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1199 aa)
MON2MON2 homolog, regulator of endosome-to-Golgi trafficking. (1686 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (972 aa)
Rep15Uncharacterized protein. (236 aa)
RAB21RAB21, member RAS oncogene family. (221 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
RAB4ARAB4A, member RAS oncogene family. (218 aa)
SNX16Sorting nexin 16. (344 aa)
NEU3Neuraminidase 3. (435 aa)
WDR81WD repeat domain 81. (1941 aa)
Tsg101SB domain-containing protein. (325 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
I3N4W4_ICTTRRING-CH-type domain-containing protein. (261 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (636 aa)
PLA2G4EPhospholipase A2. (876 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
EPHB1EPH receptor B1. (984 aa)
UBXN6UBX domain protein 6. (442 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1045 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (699 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (394 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (901 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (461 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
ATP11BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1174 aa)
Vps33bUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.