STRINGSTRING
BMPR1A BMPR1A Cks2 Cks2 ERBB4 ERBB4 PIBF1 PIBF1 EREG EREG GPRC5D GPRC5D DUSP19 DUSP19 DELE1 DELE1 INSR INSR AGAP2 AGAP2 TGFB2 TGFB2 PDGFC PDGFC BMPR2 BMPR2 Map2k2 Map2k2 LOC101973790 LOC101973790 DAXX DAXX RIPK3 RIPK3 STK11 STK11 Cd86 Cd86 ALK ALK Itgb3 Itgb3 CAB39L CAB39L ALKAL1 ALKAL1 EPGN EPGN ERCC6 ERCC6 PRRC1 PRRC1 DRD2 DRD2 CALCA CALCA PRKCD PRKCD HNF1A HNF1A TRAF4 TRAF4 MOB3C MOB3C RICTOR RICTOR CD40LG CD40LG LOC101973389 LOC101973389 JAK2 JAK2 EGFR EGFR CARD10 CARD10 TRAF6 TRAF6 CHRNA3 CHRNA3 TPX2 TPX2 ANGPT1 ANGPT1 CCNQ CCNQ PAK2 PAK2 TAL1 TAL1 PRLR PRLR AREG AREG LTF LTF PARP16 PARP16 MAP2K1 MAP2K1 PPP2R3C PPP2R3C CDK5R1 CDK5R1 P2RX7 P2RX7 TGFB1 TGFB1 TIRAP TIRAP CCNT2 CCNT2 CCNY CCNY UCN UCN BORA BORA TRAF2 TRAF2 Tom1l1 Tom1l1 AXIN1 AXIN1 PIK3CA PIK3CA PDPK1 PDPK1 EPO EPO Fgf13 Fgf13 BTC BTC TAOK1 TAOK1 INCENP INCENP DGKQ DGKQ ACVR2B ACVR2B BMPR1B BMPR1B PRNP PRNP CHI3L1 CHI3L1 Zfp91 Zfp91 CCNYL1 CCNYL1 IL18 IL18 LEP LEP TNFSF15 TNFSF15 ADRA2B ADRA2B COPS8 COPS8 Spry2 Spry2 Ect2 Ect2 AGT AGT FAM20A FAM20A Ins Ins CAB39 CAB39 NRG2 NRG2 MAP3K12 MAP3K12 NCKAP1L NCKAP1L MALT1 MALT1 MOB2 MOB2 ADNP ADNP NTF3 NTF3 EMP2 EMP2 CCDC88A CCDC88A RPLP1 RPLP1 IGF2 IGF2 DAB2IP DAB2IP BMP2 BMP2 PDGFB PDGFB ETAA1 ETAA1 SPDYA SPDYA CDKN1A CDKN1A LOC101961074 LOC101961074 SLC1A1 SLC1A1 WNT5A WNT5A MOB3A MOB3A ANGPT4 ANGPT4 WNT11 WNT11 PHB2 PHB2 CDK5R2 CDK5R2 ALKAL2 ALKAL2 GAS6 GAS6 RGCC RGCC FGF1 FGF1 MNAT1 MNAT1 GREM1 GREM1 CLSPN CLSPN Phb Phb MT3 MT3 GPRC5C GPRC5C STRADB STRADB MOB1B MOB1B GPRC5B GPRC5B DBF4 DBF4 CCNT1 CCNT1 GHRL GHRL ERBB3 ERBB3 HBEGF HBEGF LOC101963381 LOC101963381 STAP1 STAP1 ENSSTOP00000024401 ENSSTOP00000024401 TGFA TGFA LOC101962631 LOC101962631 CKS1B CKS1B TGFBR2 TGFBR2 IRAK1 IRAK1 GPRC5A GPRC5A ENSSTOP00000025794 ENSSTOP00000025794 ALS2 ALS2 ITGB1BP1 ITGB1BP1 SLC11A1 SLC11A1 ENSSTOP00000026404 ENSSTOP00000026404 OSBPL8 OSBPL8 IKBKG IKBKG PRKAG2 PRKAG2 LOC101973512 LOC101973512 STRADA STRADA IQGAP1 IQGAP1 MAS1 MAS1 ABI1 ABI1 CCNK CCNK NTRK3 NTRK3 MAP3K13 MAP3K13 CAMKK2 CAMKK2 ENSSTOP00000029589 ENSSTOP00000029589 MLST8 MLST8 IGF1 IGF1 MOB1A MOB1A MOB3B MOB3B PTK2B PTK2B AFAP1L2 AFAP1L2 ADCY8 ADCY8 ENSSTOP00000031040 ENSSTOP00000031040 RPTOR RPTOR CAMKK1 CAMKK1 NRG1 NRG1 WNK1 WNK1 MAP3K7 MAP3K7 MTCP1 MTCP1 LOC101968601 LOC101968601
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
EREGEpiregulin. (163 aa)
GPRC5DG protein-coupled receptor class C group 5 member D. (300 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
DELE1DAP3 binding cell death enhancer 1. (511 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1116 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
LOC101973790Uncharacterized protein. (311 aa)
DAXXDeath domain associated protein. (740 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
Cd86Ig-like domain-containing protein. (289 aa)
ALKTyrosine-protein kinase receptor. (1612 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
CAB39LCalcium binding protein 39 like. (315 aa)
ALKAL1ALK and LTK ligand 1. (128 aa)
EPGNEpithelial mitogen. (153 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1521 aa)
PRRC1Proline rich coiled-coil 1. (445 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CALCACalcitonin related polypeptide alpha. (137 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HNF1AHNF1 homeobox A. (449 aa)
TRAF4TNF receptor-associated factor. (470 aa)
MOB3CMOB kinase activator 3C. (216 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1660 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (259 aa)
LOC101973389Uncharacterized protein. (182 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
CARD10Caspase recruitment domain family member 10. (1023 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (502 aa)
TPX2TPX2 microtubule nucleation factor. (746 aa)
ANGPT1Angiopoietin 1. (497 aa)
CCNQCyclin Q; Belongs to the cyclin family. (250 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (616 aa)
AREGAmphiregulin. (252 aa)
LTFLactotransferrin; Belongs to the transferrin family. (709 aa)
PARP16Poly [ADP-ribose] polymerase. (321 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (728 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
UCNUrocortin. (127 aa)
BORABORA aurora kinase A activator. (546 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Tom1l1Uncharacterized protein. (282 aa)
AXIN1Axin 1. (869 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
Fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
BTCBetacellulin. (143 aa)
TAOK1TAO kinase 1. (1001 aa)
INCENPInner centromere protein. (826 aa)
DGKQDiacylglycerol kinase. (924 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PRNPMajor prion protein; Belongs to the prion family. (247 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (382 aa)
Zfp91Uncharacterized protein. (564 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (340 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TNFSF15TNF superfamily member 15. (257 aa)
ADRA2BAdrenoceptor alpha 2B. (449 aa)
COPS8COP9 signalosome subunit 8. (209 aa)
Spry2Uncharacterized protein. (315 aa)
Ect2Uncharacterized protein. (188 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (538 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CAB39Calcium binding protein 39. (341 aa)
NRG2Neuregulin 2. (767 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
MALT1MALT1 paracaspase. (747 aa)
MOB2MOB kinase activator 2. (266 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
CCDC88ACoiled-coil domain containing 88A. (1873 aa)
RPLP1Ribosomal protein lateral stalk subunit P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
IGF2Insulin like growth factor 2. (180 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ETAA1ETAA1 activator of ATR kinase. (894 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (312 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
LOC101961074Uncharacterized protein. (295 aa)
SLC1A1Amino acid transporter. (523 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MOB3AMOB kinase activator 3A. (217 aa)
ANGPT4Angiopoietin 4. (496 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PHB2Prohibitin. (299 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
ALKAL2ALK and LTK ligand 2. (131 aa)
GAS6Growth arrest specific 6. (654 aa)
RGCCRegulator of cell cycle. (161 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
GREM1Gremlin. (184 aa)
CLSPNClaspin. (1320 aa)
PhbProhibitin. (272 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
GPRC5CG protein-coupled receptor class C group 5 member C. (445 aa)
STRADBSTE20 related adaptor beta. (418 aa)
MOB1BMOB kinase activator 1B. (216 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (411 aa)
DBF4DBF4 zinc finger. (570 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (726 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1248 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
LOC101963381Prohibitin. (297 aa)
STAP1Signal transducing adaptor family member 1. (297 aa)
ENSSTOP00000024401Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (68 aa)
TGFATransforming growth factor alpha. (159 aa)
LOC101962631Prohibitin. (247 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (357 aa)
ENSSTOP00000025794Uncharacterized protein. (78 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
SLC11A1Solute carrier family 11 member 1. (548 aa)
ENSSTOP00000026404Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (890 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
LOC101973512Uncharacterized protein. (473 aa)
STRADASTE20 related adaptor alpha. (431 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa)
ABI1Abl interactor 1. (508 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
ENSSTOP00000029589TNF receptor-associated factor. (402 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
IGF1Insulin like growth factor 1. (166 aa)
MOB1AMOB kinase activator 1A. (216 aa)
MOB3BMOB kinase activator 3B. (235 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
AFAP1L2Actin filament associated protein 1 like 2. (846 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ENSSTOP00000031040Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (69 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (505 aa)
NRG1Neuregulin 1. (700 aa)
WNK1WNK lysine deficient protein kinase 1. (2635 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
LOC101968601Uncharacterized protein. (80 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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