(19 nodes) Activation of protein kinase B activity network (Ictidomys tridecemlineatus)

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Your Input:
	Ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	INSR	Tyrosine-protein kinase receptor. (1359 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (556 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	ADRA2B	Adrenoceptor alpha 2B. (449 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
	CCDC88A	Coiled-coil domain containing 88A. (1873 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	SLC1A1	Amino acid transporter. (523 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	GAS6	Growth arrest specific 6. (654 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	MT3	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (890 aa)
	LOC101973512	Uncharacterized protein. (473 aa)
	NTRK3	Tyrosine-protein kinase receptor. (864 aa)
	IGF1	Insulin like growth factor 1. (166 aa)
	NRG1	Neuregulin 1. (700 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF1	IGF1	ENSSTOP00000021782	ENSSTOP00000029785	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Insulin like growth factor 1.	0.564
FGF1	INSR	ENSSTOP00000021782	ENSSTOP00000000977	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Tyrosine-protein kinase receptor.	0.848
FGF1	Ins	ENSSTOP00000021782	ENSSTOP00000017025	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.501
FGF1	NTF3	ENSSTOP00000021782	ENSSTOP00000018090	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.477
FGF1	NTRK3	ENSSTOP00000021782	ENSSTOP00000028745	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Tyrosine-protein kinase receptor.	0.811
GAS6	NTRK3	ENSSTOP00000021634	ENSSTOP00000028745	Growth arrest specific 6.	Tyrosine-protein kinase receptor.	0.439
IGF1	FGF1	ENSSTOP00000029785	ENSSTOP00000021782	Insulin like growth factor 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.564
IGF1	INSR	ENSSTOP00000029785	ENSSTOP00000000977	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.995
IGF1	Ins	ENSSTOP00000029785	ENSSTOP00000017025	Insulin like growth factor 1.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.956
IGF1	NTF3	ENSSTOP00000029785	ENSSTOP00000018090	Insulin like growth factor 1.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.412
IGF1	NTRK3	ENSSTOP00000029785	ENSSTOP00000028745	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.883
IGF1	PDGFB	ENSSTOP00000029785	ENSSTOP00000019197	Insulin like growth factor 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.910
INSR	FGF1	ENSSTOP00000000977	ENSSTOP00000021782	Tyrosine-protein kinase receptor.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.848
INSR	IGF1	ENSSTOP00000000977	ENSSTOP00000029785	Tyrosine-protein kinase receptor.	Insulin like growth factor 1.	0.995
INSR	Ins	ENSSTOP00000000977	ENSSTOP00000017025	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.995
INSR	NTF3	ENSSTOP00000000977	ENSSTOP00000018090	Tyrosine-protein kinase receptor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.874
INSR	NTRK3	ENSSTOP00000000977	ENSSTOP00000028745	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.481
INSR	PDGFB	ENSSTOP00000000977	ENSSTOP00000019197	Tyrosine-protein kinase receptor.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.878
INSR	PDPK1	ENSSTOP00000000977	ENSSTOP00000011658	Tyrosine-protein kinase receptor.	3-phosphoinositide dependent protein kinase 1.	0.623
Ins	FGF1	ENSSTOP00000017025	ENSSTOP00000021782	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.501