13 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	PLA2G3	Phospholipase A2 group III. (626 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	PTGES	Prostaglandin E synthase. (153 aa)
	PLA2G10	Phospholipase A(2). (148 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	LOC101967926	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (625 aa)
	P2RY2	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	LOC101967640	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	PLA2G4A	Phospholipase A2. (750 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1B	MAPK9	ENSSTOP00000002047	ENSSTOP00000030639	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Mitogen-activated protein kinase.	0.612
IL1B	P2RX7	ENSSTOP00000002047	ENSSTOP00000008819	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.414
IL1B	PTGES	ENSSTOP00000002047	ENSSTOP00000004391	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Prostaglandin E synthase.	0.414
IL1B	TNFSF11	ENSSTOP00000002047	ENSSTOP00000009059	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.482
MAPK9	IL1B	ENSSTOP00000030639	ENSSTOP00000002047	Mitogen-activated protein kinase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.612
P2RX4	P2RX7	ENSSTOP00000026580	ENSSTOP00000008819	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.809
P2RX4	P2RY2	ENSSTOP00000026580	ENSSTOP00000019862	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family.	0.441
P2RX7	IL1B	ENSSTOP00000008819	ENSSTOP00000002047	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.414
P2RX7	P2RX4	ENSSTOP00000008819	ENSSTOP00000026580	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.809
P2RX7	P2RY2	ENSSTOP00000008819	ENSSTOP00000019862	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family.	0.497
P2RY2	P2RX4	ENSSTOP00000019862	ENSSTOP00000026580	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.441
P2RY2	P2RX7	ENSSTOP00000019862	ENSSTOP00000008819	Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.497
PLA2G10	PLA2G3	ENSSTOP00000006769	ENSSTOP00000002006	Phospholipase A(2).	Phospholipase A2 group III.	0.930
PLA2G10	PLA2G4A	ENSSTOP00000006769	ENSSTOP00000031303	Phospholipase A(2).	Phospholipase A2.	0.918
PLA2G10	TNFSF11	ENSSTOP00000006769	ENSSTOP00000009059	Phospholipase A(2).	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.469
PLA2G3	PLA2G10	ENSSTOP00000002006	ENSSTOP00000006769	Phospholipase A2 group III.	Phospholipase A(2).	0.930
PLA2G3	PLA2G4A	ENSSTOP00000002006	ENSSTOP00000031303	Phospholipase A2 group III.	Phospholipase A2.	0.860
PLA2G4A	PLA2G10	ENSSTOP00000031303	ENSSTOP00000006769	Phospholipase A2.	Phospholipase A(2).	0.918
PLA2G4A	PLA2G3	ENSSTOP00000031303	ENSSTOP00000002006	Phospholipase A2.	Phospholipase A2 group III.	0.860
PTGES	IL1B	ENSSTOP00000004391	ENSSTOP00000002047	Prostaglandin E synthase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.414