STRINGSTRING
NTRK2 NTRK2 STK4 STK4 Ptgs2 Ptgs2 HSP90AA1 HSP90AA1 TGFB1 TGFB1 MAD2L2 MAD2L2 HCLS1 HCLS1 Osm Osm ATP2B4 ATP2B4 PFN2 PFN2 MAPKAP1 MAPKAP1 UCN UCN OPRD1 OPRD1 AXIN1 AXIN1 PAK1 PAK1 TNF TNF PIK3CA PIK3CA LATS1 LATS1 HDAC6 HDAC6 HAX1 HAX1 Bcar3 Bcar3 CNOT9 CNOT9 RIPK2 RIPK2 CAV1 CAV1 BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR Spry2 Spry2 AGT AGT AVP AVP LOC101970905 LOC101970905 FNIP1 FNIP1 I3N090_ICTTR I3N090_ICTTR NTF3 NTF3 SMYD3 SMYD3 LOC101960206 LOC101960206 MET MET STOX1 STOX1 RAF1 RAF1 IFNE IFNE Pdcd10 Pdcd10 LOC101968765 LOC101968765 Ifnk Ifnk PHIP PHIP WNT5A WNT5A WNT3A WNT3A GAS6 GAS6 RAMP3 RAMP3 HSP90AB1 HSP90AB1 Ntf4 Ntf4 LOC101975245 LOC101975245 NOS1 NOS1 ARRB2 ARRB2 ARRB1 ARRB1 PINK1 PINK1 TNKS1BP1 TNKS1BP1 ENSSTOP00000025799 ENSSTOP00000025799 LOC101969049 LOC101969049 APP APP EIF4G1 EIF4G1 ENSSTOP00000027321 ENSSTOP00000027321 CREBL2 CREBL2 AKT1 AKT1 NTRK3 NTRK3 TENM1 TENM1 ENSSTOP00000028887 ENSSTOP00000028887 TEK TEK RPTOR RPTOR ENSSTOP00000032295 ENSSTOP00000032295 PRKD2 PRKD2 MTCP1 MTCP1 SNCA SNCA I3LX54_ICTTR I3LX54_ICTTR IL11 IL11 GSK3A GSK3A RAPGEF3 RAPGEF3 RET RET CAMK1 CAMK1 SFRP2 SFRP2 LOC101973790 LOC101973790 BRAF BRAF AKT2 AKT2 ERCC6 ERCC6 I3M249_ICTTR I3M249_ICTTR TFRC TFRC PRKD1 PRKD1 ARAF ARAF CAPRIN2 CAPRIN2 I3M4W8_ICTTR I3M4W8_ICTTR GCG GCG DOCK7 DOCK7 CSF3 CSF3 FNIP2 FNIP2 I3NE76_ICTTR I3NE76_ICTTR TRIM6 TRIM6 LIF LIF AKAP9 AKAP9 EGFR EGFR BAG4 BAG4 ANGPT1 ANGPT1 SH2D3C SH2D3C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NTRK2Tyrosine-protein kinase receptor. (821 aa)
STK4Serine/threonine kinase 4. (488 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (478 aa)
OsmUncharacterized protein. (214 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
UCNUrocortin. (127 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
AXIN1Axin 1. (869 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LATS1Large tumor suppressor kinase 1. (1131 aa)
HDAC6Histone deacetylase 6. (1142 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (253 aa)
Bcar3Uncharacterized protein. (186 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
Spry2Uncharacterized protein. (315 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (145 aa)
LOC101970905NGF domain-containing protein; Belongs to the NGF-beta family. (210 aa)
FNIP1Folliculin interacting protein 1. (1164 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
LOC101960206Uncharacterized protein. (207 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
STOX1Storkhead box 1. (983 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
IFNEInterferon epsilon. (184 aa)
Pdcd10Programmed cell death 10. (212 aa)
LOC101968765Uncharacterized protein. (187 aa)
IfnkUncharacterized protein. (241 aa)
PHIPPleckstrin homology domain interacting protein. (1777 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GAS6Growth arrest specific 6. (654 aa)
RAMP3Receptor activity modifying protein 3. (147 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
Ntf4NGF domain-containing protein; Belongs to the NGF-beta family. (210 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
ARRB2Arrestin beta 2. (409 aa)
ARRB1Arrestin beta 1. (418 aa)
PINK1PTEN induced kinase 1. (574 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1720 aa)
ENSSTOP00000025799LAM_G_DOMAIN domain-containing protein. (176 aa)
LOC101969049Uncharacterized protein. (174 aa)
APPAmyloid beta precursor protein. (739 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1611 aa)
ENSSTOP00000027321Uncharacterized protein. (207 aa)
CREBL2cAMP responsive element binding protein like 2. (120 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
ENSSTOP00000028887Uncharacterized protein. (184 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
I3LX54_ICTTRUncharacterized protein. (327 aa)
IL11Interleukin 11. (199 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (395 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (898 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
LOC101973790Uncharacterized protein. (311 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1521 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
TFRCTransferrin receptor. (760 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CAPRIN2Caprin family member 2. (1205 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
GCGGlucagon. (180 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2131 aa)
CSF3Colony stimulating factor 3. (210 aa)
FNIP2Folliculin interacting protein 2. (1182 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
TRIM6Tripartite motif containing 6. (469 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
AKAP9A-kinase anchoring protein 9. (3713 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
BAG4BCL2 associated athanogene 4. (324 aa)
ANGPT1Angiopoietin 1. (497 aa)
SH2D3CSH2 domain containing 3C. (858 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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