STRINGSTRING
SESN1 SESN1 MTOR MTOR SH3GLB1 SH3GLB1 NPRL3 NPRL3 Depdc5 Depdc5 ITFG2 ITFG2 TFEB TFEB Becn1 Becn1 WDR59 WDR59 ATF4 ATF4 RNF152 RNF152 BMT2 BMT2 CDKN1A CDKN1A RNF167 RNF167 I3MU88_ICTTR I3MU88_ICTTR IMPACT IMPACT SLC38A2 SLC38A2 NPRL2 NPRL2 EIF2AK4 EIF2AK4 MAPK1 MAPK1 MIOS MIOS ATF2 ATF2 GCN1 GCN1 EIF2AK2 EIF2AK2 MAPK8 MAPK8 FLCN FLCN ULK1 ULK1 RRAGC RRAGC UCP2 UCP2 EIF2AK3 EIF2AK3 SESN2 SESN2 MAP3K5 MAP3K5 SEH1L SEH1L DAPL1 DAPL1 RRAGD RRAGD ATF3 ATF3 KPTN KPTN MAP1LC3A MAP1LC3A HNRNPL HNRNPL RRAGB RRAGB C12orf66 C12orf66 WDR24 WDR24 PRKD1 PRKD1 LARS1 LARS1 EIF2S1 EIF2S1 MAPK3 MAPK3 SESN3 SESN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN1Sestrin 1. (552 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (387 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
Depdc5DEP domain-containing protein. (1482 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
TFEBTranscription factor EB. (474 aa)
Becn1Beclin 1. (448 aa)
WDR59WD repeat domain 59. (916 aa)
ATF4Activating transcription factor 4. (352 aa)
RNF152Ring finger protein 152. (203 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
RNF167Ring finger protein 167. (345 aa)
I3MU88_ICTTRUncharacterized protein. (83 aa)
IMPACTImpact RWD domain protein. (297 aa)
SLC38A2Solute carrier family 38 member 2. (509 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
GCN1GCN1 activator of EIF2AK4. (2664 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FLCNFolliculin. (579 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
RRAGCRas related GTP binding C. (320 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
SESN2Sestrin 2. (479 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (323 aa)
DAPL1Death associated protein like 1. (110 aa)
RRAGDRas related GTP binding D. (399 aa)
ATF3Activating transcription factor 3. (181 aa)
KPTNKaptin, actin binding protein. (402 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
HNRNPLHeterogeneous nuclear ribonucleoprotein L. (588 aa)
RRAGBRas related GTP binding B. (374 aa)
C12orf66Chromosome 12 open reading frame 66. (445 aa)
WDR24WD repeat domain 24. (789 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1176 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
SESN3Sestrin 3. (492 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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