(46 nodes) miRNA binding network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TRIM71	Tripartite motif containing 71. (868 aa)
	ENSSTOP00000028903	Uncharacterized protein. (316 aa)
	ENSSTOP00000027688	Uncharacterized protein. (316 aa)
	RBM10	RNA binding motif protein 10. (932 aa)
	LOC101968724	Uncharacterized protein. (292 aa)
	ZNF346	Zinc finger protein 346. (294 aa)
	ENSSTOP00000025854	CSD_1 domain-containing protein. (317 aa)
	PUM1	Pumilio RNA binding family member 1. (1188 aa)
	ENSSTOP00000024016	RRM domain-containing protein. (234 aa)
	AGO3	Argonaute RISC catalytic component 3; Belongs to the argonaute family. (819 aa)
	YBX1	Y-box binding protein 1. (290 aa)
	TUT7	Terminal uridylyl transferase 7. (1475 aa)
	FMR1	Fragile X mental retardation 1. (631 aa)
	Lin28a	CCHC-type domain-containing protein. (210 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	ZC3H7A	Zinc finger CCCH-type containing 7A. (970 aa)
	PUM2	Pumilio RNA binding family member 2. (1064 aa)
	Hnrnpa1	Uncharacterized protein. (374 aa)
	ZC3H10	Zinc finger CCCH-type containing 10. (435 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (862 aa)
	ELAVL1	ELAV-like protein; Belongs to the RRM elav family. (326 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (865 aa)
	SOCS3	Suppressor of cytokine signaling 3. (227 aa)
	DDX21	DExD-box helicase 21. (787 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	RBM4	RNA binding motif protein 4. (365 aa)
	I3N8Q7_ICTTR	Uncharacterized protein. (292 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (784 aa)
	Pou5f1	POU domain protein. (360 aa)
	ZC3H7B	Zinc finger CCCH-type containing 7B. (979 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1130 aa)
	SPOUT1	SPOUT domain containing methyltransferase 1. (378 aa)
	TUT4	Terminal uridylyl transferase 4. (1661 aa)
	Matr3	Uncharacterized protein. (849 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)
	ENSSTOP00000032132	RRM domain-containing protein. (282 aa)
	ENSSTOP00000031875	Uncharacterized protein. (274 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	ENSSTOP00000031278	CSP domain-containing protein. (186 aa)
	ENSSTOP00000030920	Uncharacterized protein. (284 aa)
	ENSSTOP00000030697	RRM domain-containing protein. (311 aa)
	ENSSTOP00000030446	Uncharacterized protein. (213 aa)
	LOC101961297	Uncharacterized protein. (302 aa)
	HNRNPA2B1	Uncharacterized protein. (353 aa)
	ENSSTOP00000029470	POU-specific domain-containing protein. (311 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSSTOP00000009740	ENSSTOP00000007282	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.990
AGO1	AGO3	ENSSTOP00000009740	ENSSTOP00000023469	Argonaute RISC component 1; Belongs to the argonaute family.	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	0.878
AGO1	AGO4	ENSSTOP00000009740	ENSSTOP00000004264	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.785
AGO1	DICER1	ENSSTOP00000009740	ENSSTOP00000023439	Argonaute RISC component 1; Belongs to the argonaute family.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.984
AGO1	ELAVL1	ENSSTOP00000009740	ENSSTOP00000008183	Argonaute RISC component 1; Belongs to the argonaute family.	ELAV-like protein; Belongs to the RRM elav family.	0.469
AGO1	FMR1	ENSSTOP00000009740	ENSSTOP00000002918	Argonaute RISC component 1; Belongs to the argonaute family.	Fragile X mental retardation 1.	0.746
AGO1	PUM2	ENSSTOP00000009740	ENSSTOP00000005609	Argonaute RISC component 1; Belongs to the argonaute family.	Pumilio RNA binding family member 2.	0.439
AGO1	TARBP2	ENSSTOP00000009740	ENSSTOP00000031808	Argonaute RISC component 1; Belongs to the argonaute family.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.949
AGO2	AGO1	ENSSTOP00000007282	ENSSTOP00000009740	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.990
AGO2	AGO3	ENSSTOP00000007282	ENSSTOP00000023469	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	0.984
AGO2	AGO4	ENSSTOP00000007282	ENSSTOP00000004264	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.958
AGO2	DICER1	ENSSTOP00000007282	ENSSTOP00000023439	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.994
AGO2	ELAVL1	ENSSTOP00000007282	ENSSTOP00000008183	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	ELAV-like protein; Belongs to the RRM elav family.	0.823
AGO2	ENSSTOP00000025854	ENSSTOP00000007282	ENSSTOP00000025854	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CSD_1 domain-containing protein.	0.561
AGO2	FMR1	ENSSTOP00000007282	ENSSTOP00000002918	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Fragile X mental retardation 1.	0.750
AGO2	PUM1	ENSSTOP00000007282	ENSSTOP00000024134	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Pumilio RNA binding family member 1.	0.438
AGO2	PUM2	ENSSTOP00000007282	ENSSTOP00000005609	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Pumilio RNA binding family member 2.	0.576
AGO2	RBM4	ENSSTOP00000007282	ENSSTOP00000020949	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RNA binding motif protein 4.	0.601
AGO2	RC3H1	ENSSTOP00000007282	ENSSTOP00000014349	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ring finger and CCCH-type domains 1.	0.479
AGO2	TARBP2	ENSSTOP00000007282	ENSSTOP00000031808	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.988