(18 nodes) Clathrin adaptor activity network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	AP1G2	AP-1 complex subunit gamma. (786 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (180 aa)
	SNAP91	Synaptosome associated protein 91. (902 aa)
	STON2	Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (899 aa)
	AP1M2	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (914 aa)
	AP1G1	AP-1 complex subunit gamma. (825 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1037 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	HIP1	Huntingtin interacting protein 1. (989 aa)
	AP1M1	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	Ston1	Stonin-1; May be involved in the endocytic machinery. (735 aa)
	DAB2	DAB adaptor protein 2. (767 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1G1	AP1G2	ENSSTOP00000013710	ENSSTOP00000002405	AP-1 complex subunit gamma.	AP-1 complex subunit gamma.	0.894
AP1G1	AP1M1	ENSSTOP00000013710	ENSSTOP00000024089	AP-1 complex subunit gamma.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.990
AP1G1	AP1M2	ENSSTOP00000013710	ENSSTOP00000006907	AP-1 complex subunit gamma.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.990
AP1G1	AP1S1	ENSSTOP00000013710	ENSSTOP00000000664	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.995
AP1G1	AP1S2	ENSSTOP00000013710	ENSSTOP00000027602	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.993
AP1G1	AP1S3	ENSSTOP00000013710	ENSSTOP00000008615	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.993
AP1G1	AP2A1	ENSSTOP00000013710	ENSSTOP00000024091	AP-1 complex subunit gamma.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.491
AP1G1	AP2A2	ENSSTOP00000013710	ENSSTOP00000010125	AP-1 complex subunit gamma.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.414
AP1G1	AP2M1	ENSSTOP00000013710	ENSSTOP00000007414	AP-1 complex subunit gamma.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.958
AP1G1	ARRB1	ENSSTOP00000013710	ENSSTOP00000024223	AP-1 complex subunit gamma.	Arrestin beta 1.	0.521
AP1G1	DAB2	ENSSTOP00000013710	ENSSTOP00000031387	AP-1 complex subunit gamma.	DAB adaptor protein 2.	0.422
AP1G1	HIP1	ENSSTOP00000013710	ENSSTOP00000021846	AP-1 complex subunit gamma.	Huntingtin interacting protein 1.	0.645
AP1G1	HIP1R	ENSSTOP00000013710	ENSSTOP00000018273	AP-1 complex subunit gamma.	Huntingtin interacting protein 1 related.	0.645
AP1G1	SNAP91	ENSSTOP00000013710	ENSSTOP00000001167	AP-1 complex subunit gamma.	Synaptosome associated protein 91.	0.731
AP1G1	STON2	ENSSTOP00000013710	ENSSTOP00000005292	AP-1 complex subunit gamma.	Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family.	0.570
AP1G2	AP1G1	ENSSTOP00000002405	ENSSTOP00000013710	AP-1 complex subunit gamma.	AP-1 complex subunit gamma.	0.894
AP1G2	AP1M1	ENSSTOP00000002405	ENSSTOP00000024089	AP-1 complex subunit gamma.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.985
AP1G2	AP1M2	ENSSTOP00000002405	ENSSTOP00000006907	AP-1 complex subunit gamma.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.985
AP1G2	AP1S1	ENSSTOP00000002405	ENSSTOP00000000664	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.993
AP1G2	AP1S2	ENSSTOP00000002405	ENSSTOP00000027602	AP-1 complex subunit gamma.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.989