STRINGSTRING
ABAT ABAT NKX3-1 NKX3-1 ENSSTOP00000025283 ENSSTOP00000025283 AGER AGER USF1 USF1 P2RX3 P2RX3 Becn1 Becn1 IRAK1 IRAK1 CFLAR CFLAR KCNMA1 KCNMA1 KCND2 KCND2 ARNT ARNT TGFBR2 TGFBR2 ENSSTOP00000024875 ENSSTOP00000024875 PINK1 PINK1 ENSSTOP00000024708 ENSSTOP00000024708 CYBA CYBA NPEPPS NPEPPS TXN2 TXN2 ENSSTOP00000024304 ENSSTOP00000024304 TM9SF4 TM9SF4 CAMK2G CAMK2G PSEN2 PSEN2 ITPR2 ITPR2 PAM PAM SCAP SCAP SCN2A SCN2A PRKAA1 PRKAA1 I3NHR2_ICTTR I3NHR2_ICTTR ATF4 ATF4 DICER1 DICER1 PPARD PPARD NOS1 NOS1 ALKBH5 ALKBH5 DNMT3A DNMT3A MIEF1 MIEF1 EGLN3 EGLN3 CYBB CYBB MT3 MT3 CAMK2D CAMK2D TH TH TGFB3 TGFB3 TLR2 TLR2 LOC101972479 LOC101972479 TRH TRH Ptgs2 Ptgs2 CAPN2 CAPN2 Hif1an Hif1an IREB2 IREB2 MPL MPL SCFD1 SCFD1 ADAM15 ADAM15 SLC2A4 SLC2A4 CITED2 CITED2 ALDH3A1 ALDH3A1 BAD BAD AIFM1 AIFM1 ENG ENG NOX4 NOX4 ANGPTL4 ANGPTL4 ALAS2 ALAS2 LOC101954543 LOC101954543 MTHFR MTHFR STC1 STC1 Rest Rest FNDC1 FNDC1 VLDLR VLDLR WDR83 WDR83 Eif4ebp1 Eif4ebp1 VEGFD VEGFD CYGB CYGB PLK3 PLK3 GNGT1 GNGT1 HIGD1A HIGD1A PLAT PLAT SIRT4 SIRT4 SLC9A1 SLC9A1 PLOD1 PLOD1 TNFRSF1A TNFRSF1A CRYAB CRYAB KCNK2 KCNK2 SMAD3 SMAD3 GNB1 GNB1 ITGA2 ITGA2 UCP2 UCP2 FAM167A FAM167A ERCC3 ERCC3 TBL2 TBL2 BRIP1 BRIP1 HP1BP3 HP1BP3 DDR2 DDR2 MYOCD MYOCD NARF NARF DNM1L DNM1L OPRD1 OPRD1 ERO1A ERO1A RORA RORA BNIP3 BNIP3 PRKCE PRKCE EPAS1 EPAS1 TACC3 TACC3 PPARG PPARG PAK1 PAK1 PICK1 PICK1 LTA LTA TSC2 TSC2 SLC11A2 SLC11A2 CAV3 CAV3 PML PML LCT LCT EPO EPO MST1 MST1 VHL VHL ATF2 ATF2 SRF SRF VEGFB VEGFB HYOU1 HYOU1 Mdm2 Mdm2 RYR2 RYR2 PCK1 PCK1 SLC39A12 SLC39A12 PDK3 PDK3 PLD2 PLD2 SUV39H1 SUV39H1 Aqp1 Aqp1 AQP3 AQP3 LOXL2 LOXL2 ADIPOQ ADIPOQ KDR KDR HSD11B2 HSD11B2 PRMT2 PRMT2 AK4 AK4 CHRNA4 CHRNA4 CDKN1B CDKN1B IL18 IL18 LEP LEP STUB1 STUB1 SIRT1 SIRT1 NFATC3 NFATC3 HIF3A HIF3A BNIP3L BNIP3L CAV1 CAV1 TGFBR3 TGFBR3 XRCC1 XRCC1 PTEN PTEN ENDOG ENDOG KCNMB1 KCNMB1 FUNDC1 FUNDC1 BCL2 BCL2 SFRP1 SFRP1 LIMD1 LIMD1 EGR1 EGR1 VASN VASN RYR1 RYR1 MMP2 MMP2 SMAD4 SMAD4 NOS2 NOS2 Cpeb1 Cpeb1 NDRG1 NDRG1 FLT1 FLT1 OXTR OXTR LONP1 LONP1 TIGAR TIGAR CBFA2T3 CBFA2T3 Vcam1 Vcam1 GATA6 GATA6 BMP2 BMP2 NPPC NPPC P2RX2 P2RX2 TERT TERT LOC101972772 LOC101972772 STOX1 STOX1 AJUBA AJUBA Egln1 Egln1 PTGIS PTGIS TP53 TP53 ACAA2 ACAA2 APAF1 APAF1 SLC1A1 SLC1A1 NOL3 NOL3 EGLN2 EGLN2 I3N7W8_ICTTR I3N7W8_ICTTR PGF PGF NDNF NDNF NOP53 NOP53 ANGPT4 ANGPT4 MMP14 MMP14 PHB2 PHB2 FOSL2 FOSL2 SIRT2 SIRT2 EDNRA EDNRA ASCL2 ASCL2 F7 F7 CAPN14 CAPN14 MGARP MGARP RGCC RGCC HMOX2 HMOX2 WTIP WTIP P4HB P4HB Birc2 Birc2 Foxo3 Foxo3 CXCL12 CXCL12 CXCR4 CXCR4 MT-ND4 MT-ND4 LOC101968601 LOC101968601 ENSSTOP00000032295 ENSSTOP00000032295 MTOR MTOR PLAU PLAU ENSSTOP00000031945 ENSSTOP00000031945 AGTRAP AGTRAP TEK TEK PTK2B PTK2B NGB NGB PKLR PKLR EEF2K EEF2K ENSSTOP00000030023 ENSSTOP00000030023 ENSSTOP00000030003 ENSSTOP00000030003 ENSSTOP00000029902 ENSSTOP00000029902 PDK1 PDK1 ENSSTOP00000029050 ENSSTOP00000029050 PLOD2 PLOD2 ENSSTOP00000028695 ENSSTOP00000028695 ENSSTOP00000028494 ENSSTOP00000028494 SUV39H2 SUV39H2 AKT1 AKT1 ENSSTOP00000028389 ENSSTOP00000028389 BNIP2 BNIP2 ACTN4 ACTN4 MT-ND5 MT-ND5 CHRNB2 CHRNB2 CPEB4 CPEB4 SLC2A1 SLC2A1 Sdhd Sdhd ITPR1 ITPR1 NF1 NF1 BNIP1 BNIP1 ADM ADM Cbs Cbs Adsl Adsl HSF1 HSF1 HMOX1 HMOX1 MECP2 MECP2 Crhr1 Crhr1 LOC110597981 LOC110597981 ENSSTOP00000025928 ENSSTOP00000025928 RBPJ RBPJ ENSSTOP00000025794 ENSSTOP00000025794 HILPDA HILPDA CBL CBL SLC2A8 SLC2A8 MB MB JUN JUN ADAM8 ADAM8 KCNK3 KCNK3 NFE2L2 NFE2L2 RTN4 RTN4 ACVRL1 ACVRL1 EDN1 EDN1 ALAD ALAD DDIT4 DDIT4 EP300 EP300 GRIN2B GRIN2B TGFB2 TGFB2 LMNA LMNA VEGFC VEGFC Cpeb2 Cpeb2 HK2 HK2 ATP7A ATP7A E2F1 E2F1 NR4A2 NR4A2 ANGPT2 ANGPT2 PDGFA PDGFA SLC29A1 SLC29A1 TSC1 TSC1 DRD2 DRD2 Ado Ado TFRC TFRC SLC8A3 SLC8A3 BACH1 BACH1 ARNT2 ARNT2 Mdm4 Mdm4 CIAO3 CIAO3 STC2 STC2 FAM162A FAM162A ATM ATM ADAM17 ADAM17 PDLIM1 PDLIM1 FABP1 FABP1 Hif1a Hif1a UCP3 UCP3 DPP4 DPP4 CA9 CA9 PIN1 PIN1 HSP90B1 HSP90B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
NKX3-1NK3 homeobox 1. (144 aa)
ENSSTOP00000025283Uncharacterized protein; Belongs to the potassium channel family. (501 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
USF1Upstream transcription factor 1. (310 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
Becn1Beclin 1. (448 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (781 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSSTOP00000024875Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (131 aa)
PINK1PTEN induced kinase 1. (574 aa)
ENSSTOP00000024708Uncharacterized protein. (240 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
NPEPPSAminopeptidase. (834 aa)
TXN2Thioredoxin 2. (166 aa)
ENSSTOP00000024304ADSL_C domain-containing protein. (422 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (655 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (979 aa)
SCAPSREBF chaperone. (1322 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
I3NHR2_ICTTRUncharacterized protein. (435 aa)
ATF4Activating transcription factor 4. (352 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
MIEF1Mitochondrial elongation factor 1. (463 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
THTyrosine hydroxylase. (497 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
LOC101972479A_deaminase domain-containing protein. (338 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
Hif1anJmjC domain-containing protein. (349 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (648 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (568 aa)
ADAM15ADAM metallopeptidase domain 15. (837 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
BADBCL2 associated agonist of cell death. (208 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
ENGEndoglin. (463 aa)
NOX4NADPH oxidase 4. (578 aa)
ANGPTL4Angiopoietin like 4. (421 aa)
ALAS25-aminolevulinate synthase. (587 aa)
LOC101954543Uncharacterized protein; Belongs to the peptidase C14A family. (365 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (653 aa)
STC1Stanniocalcin 1. (247 aa)
RestUncharacterized protein. (328 aa)
FNDC1Fibronectin type III domain containing 1. (1886 aa)
VLDLRVery low density lipoprotein receptor. (873 aa)
WDR83WD repeat domain 83. (315 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (359 aa)
CYGBCytoglobin; Belongs to the globin family. (190 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
HIGD1AHIG1 hypoxia inducible domain family member 1A. (93 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (737 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (422 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GNB1G protein subunit beta 1. (340 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1183 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
FAM167AFamily with sequence similarity 167 member A. (211 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
TBL2Transducin beta like 2. (443 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (937 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (554 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
MYOCDMyocardin. (894 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (452 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
RORARAR related orphan receptor A. (521 aa)
BNIP3BCL2 interacting protein 3. (217 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
EPAS1Endothelial PAS domain protein 1. (867 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (835 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PICK1Protein interacting with PRKCA 1. (416 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
TSC2TSC complex subunit 2. (1745 aa)
SLC11A2Solute carrier family 11 member 2. (568 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PMLPromyelocytic leukemia. (877 aa)
LCTLactase. (1928 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
VHLVon Hippel-Lindau tumor suppressor. (182 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
SRFSerum response factor. (505 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (184 aa)
HYOU1Hypoxia up-regulated 1. (997 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
RYR2Ryanodine receptor 2. (4888 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
SLC39A12Solute carrier family 39 member 12. (692 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
PLD2Phospholipase. (933 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
LOXL2Lysyl oxidase like 2. (776 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (398 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (617 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
SIRT1Sirtuin 1. (602 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (677 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENDOGEndonuclease. (281 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LIMD1LIM domains containing 1. (668 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
VASNVasorin. (674 aa)
RYR1Ryanodine receptor 1. (4864 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
Cpeb1Uncharacterized protein. (566 aa)
NDRG1N-myc downstream regulated 1. (394 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (958 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (616 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
GATA6GATA binding protein 6. (593 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
NPPCNatriuretic peptide C. (126 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (455 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1079 aa)
LOC101972772A_deaminase domain-containing protein. (352 aa)
STOX1Storkhead box 1. (983 aa)
AJUBAAjuba LIM protein. (548 aa)
Egln1Fe2OG dioxygenase domain-containing protein. (127 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (414 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1247 aa)
SLC1A1Amino acid transporter. (523 aa)
NOL3Nucleolar protein 3. (210 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (417 aa)
I3N7W8_ICTTRUncharacterized protein; Belongs to the TCP-1 chaperonin family. (202 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (477 aa)
ANGPT4Angiopoietin 4. (496 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
PHB2Prohibitin. (299 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (190 aa)
F7Coagulation factor VII; Belongs to the peptidase S1 family. (375 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (674 aa)
MGARPMitochondria localized glutamic acid rich protein. (236 aa)
RGCCRegulator of cell cycle. (161 aa)
HMOX2Heme oxygenase 2. (310 aa)
WTIPWT1 interacting protein. (328 aa)
P4HBProtein disulfide-isomerase. (509 aa)
Birc2Uncharacterized protein. (611 aa)
Foxo3Forkhead box O3. (673 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MT-ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (459 aa)
LOC101968601Uncharacterized protein. (80 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
PLAUPlasminogen activator, urokinase. (424 aa)
ENSSTOP00000031945Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (140 aa)
AGTRAPAngiotensin II receptor associated protein. (158 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
NGBNeuroglobin; Belongs to the globin family. (140 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (565 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSSTOP00000030023BTB domain-containing protein; Belongs to the potassium channel family. (530 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
ENSSTOP00000029902JmjC domain-containing protein. (292 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
ENSSTOP00000029050Uncharacterized protein. (117 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (759 aa)
ENSSTOP00000028695Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (142 aa)
ENSSTOP00000028494RRM domain-containing protein. (160 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (458 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
BNIP2BCL2 interacting protein 2. (333 aa)
ACTN4Actinin alpha 4. (933 aa)
MT-ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (605 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
SdhdSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
NF1Neurofibromin 1. (2473 aa)
BNIP1BCL2 interacting protein 1. (228 aa)
ADMAdrenomedullin. (188 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (555 aa)
AdslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
HSF1Heat shock transcription factor 1. (545 aa)
HMOX1Heme oxygenase 1. (288 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
Crhr1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (416 aa)
LOC110597981Uncharacterized protein. (137 aa)
ENSSTOP00000025928Rho-GAP domain-containing protein. (67 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
ENSSTOP00000025794Uncharacterized protein. (78 aa)
HILPDAHypoxia inducible lipid droplet associated. (64 aa)
CBLCbl proto-oncogene. (870 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ADAM8ADAM metallopeptidase domain 8. (818 aa)
KCNK3Potassium two pore domain channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (364 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
RTN4Reticulon. (1177 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
EDN1Endothelin 1. (202 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (329 aa)
DDIT4DNA damage inducible transcript 4. (228 aa)
EP300E1A binding protein p300. (2423 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
Cpeb2RRM domain-containing protein. (262 aa)
HK2Hexokinase 2. (917 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
E2F1E2F transcription factor 1. (392 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ANGPT2Angiopoietin 2. (495 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (263 aa)
TSC1TSC complex subunit 1. (1164 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
AdoUncharacterized protein. (259 aa)
TFRCTransferrin receptor. (760 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (929 aa)
BACH1BTB domain and CNC homolog 1. (737 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (712 aa)
Mdm4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (476 aa)
STC2Stanniocalcin 2. (302 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
PDLIM1PDZ and LIM domain 1. (329 aa)
FABP1Fatty acid binding protein 1. (127 aa)
Hif1aUncharacterized protein. (821 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (764 aa)
CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (437 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
HSP90B1Heat shock protein 90 beta family member 1. (805 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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