STRINGSTRING
EZH2 EZH2 Wbp2 Wbp2 Fam47e Fam47e EPC1 EPC1 TDG TDG ENSSTOP00000028075 ENSSTOP00000028075 ENSSTOP00000027930 ENSSTOP00000027930 EXOSC10 EXOSC10 CTBP1 CTBP1 SUZ12 SUZ12 SMARCA5 SMARCA5 Gnas Gnas ENSSTOP00000026639 ENSSTOP00000026639 MORC1 MORC1 MECP2 MECP2 SIRT6 SIRT6 HDAC5 HDAC5 RLIM RLIM ENSSTOP00000025372 ENSSTOP00000025372 DNMT1 DNMT1 ENSSTOP00000024982 ENSSTOP00000024982 GLMN GLMN SMARCD1 SMARCD1 SMARCA4 SMARCA4 H3-3A H3-3A ZDBF2 ZDBF2 KMT2B KMT2B PHF2 PHF2 TNP1 TNP1 ENSSTOP00000018243 ENSSTOP00000018243 VPS72 VPS72 ENSSTOP00000019131 ENSSTOP00000019131 PPM1D PPM1D MPHOSPH8 MPHOSPH8 LRIF1 LRIF1 LOC110597796 LOC110597796 KCNQ1 KCNQ1 AXIN1 AXIN1 CREBZF CREBZF HELLS HELLS SMCHD1 SMCHD1 Pole3 Pole3 Hnrnpu Hnrnpu Brca1 Brca1 EP300 EP300 LHX2 LHX2 GSK3A GSK3A RB1 RB1 KDM1B KDM1B LOC101955676 LOC101955676 LMNA LMNA UBR2 UBR2 SPI1 SPI1 PRDM14 PRDM14 H3-4 H3-4 CGGBP1 CGGBP1 LOC101963257 LOC101963257 H1-0 H1-0 PCGF3 PCGF3 RBM15 RBM15 DNMT3A DNMT3A GSK3B GSK3B Hmga2 Hmga2 LMNB2 LMNB2 DICER1 DICER1 ARID4A ARID4A LOC101954283 LOC101954283 GPX1 GPX1 TRIM27 TRIM27 PPHLN1 PPHLN1 MBD2 MBD2 CDYL CDYL HDAC4 HDAC4 L3mbtl1 L3mbtl1 DOT1L DOT1L SPHK2 SPHK2 CENPV CENPV Hdac1 Hdac1 JARID2 JARID2 SMYD5 SMYD5 MACROH2A2 MACROH2A2 HAT1 HAT1 YTHDC1 YTHDC1 PRMT7 PRMT7 MORC2 MORC2 HDAC6 HDAC6 I3MNK6_ICTTR I3MNK6_ICTTR MACROH2A1 MACROH2A1 SUV39H1 SUV39H1 RRP8 RRP8 NRM NRM TASOR TASOR SIRT1 SIRT1 SPTY2D1 SPTY2D1 PCGF5 PCGF5 MTA1 MTA1 PADI2 PADI2 EED EED KMT2D KMT2D EZH1 EZH1 PABPC1L PABPC1L LMNB1 LMNB1 ASIP ASIP ARID4B ARID4B CHEK1 CHEK1 METTL3 METTL3 RIF1 RIF1 ZNFX1 ZNFX1 RBM15B RBM15B BAHD1 BAHD1 NDN NDN LOC101954283-2 LOC101954283-2 BEND3 BEND3 Dnmt3l Dnmt3l CTCF CTCF TFAP2C TFAP2C ZNF335 ZNF335 BAZ2A BAZ2A FAM172A FAM172A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
Wbp2GRAM domain-containing protein. (261 aa)
Fam47eUncharacterized protein. (433 aa)
EPC1Enhancer of polycomb homolog. (835 aa)
TDGThymine DNA glycosylase. (411 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
EXOSC10Exosome component 10. (886 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (444 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1058 aa)
GnasUncharacterized protein. (244 aa)
ENSSTOP00000026639Hist_deacetyl domain-containing protein. (323 aa)
MORC1MORC family CW-type zinc finger 1. (871 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
SIRT6Sirtuin 6. (351 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1113 aa)
RLIMRing finger protein, LIM domain interacting. (611 aa)
ENSSTOP00000025372CBFD_NFYB_HMF domain-containing protein. (134 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1532 aa)
ENSSTOP00000024982GRAM domain-containing protein. (244 aa)
GLMNGlomulin, FKBP associated protein. (596 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (505 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1646 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
ZDBF2Zinc finger DBF-type containing 2. (2414 aa)
KMT2BLysine methyltransferase 2B. (2620 aa)
PHF2PHD finger protein 2. (1063 aa)
TNP1Transition protein 1. (55 aa)
ENSSTOP00000018243annotation not available (136 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
ENSSTOP00000019131annotation not available (136 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
MPHOSPH8M-phase phosphoprotein 8. (867 aa)
LRIF1Ligand dependent nuclear receptor interacting factor 1. (759 aa)
LOC110597796H15 domain-containing protein. (175 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (592 aa)
AXIN1Axin 1. (869 aa)
CREBZFCREB/ATF bZIP transcription factor. (354 aa)
HELLSHelicase, lymphoid specific. (822 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2002 aa)
Pole3CBFD_NFYB_HMF domain-containing protein. (147 aa)
HnrnpuB30.2/SPRY domain-containing protein. (411 aa)
Brca1Uncharacterized protein. (353 aa)
EP300E1A binding protein p300. (2423 aa)
LHX2LIM homeobox 2. (406 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (395 aa)
RB1RB transcriptional corepressor 1. (957 aa)
KDM1BLysine demethylase 1B. (819 aa)
LOC101955676RING-type domain-containing protein. (326 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
PRDM14PR/SET domain 14. (499 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
CGGBP1CGG triplet repeat binding protein 1. (167 aa)
LOC101963257Histone H3; Belongs to the histone H3 family. (136 aa)
H1-0H1 histone family member 0. (194 aa)
PCGF3Polycomb group ring finger 3. (241 aa)
RBM15RNA binding motif protein 15. (962 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
Hmga2Uncharacterized protein. (109 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (623 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
ARID4AAT-rich interaction domain 4A. (1259 aa)
LOC101954283Histone H3.1. (136 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (201 aa)
TRIM27Tripartite motif containing 27. (513 aa)
PPHLN1Periphilin 1. (367 aa)
MBD2Methyl-CpG binding domain protein 2. (280 aa)
CDYLChromodomain Y like. (562 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
L3mbtl1Uncharacterized protein. (829 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1732 aa)
SPHK2Sphingosine kinase 2. (655 aa)
CENPVCentromere protein V. (219 aa)
Hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (399 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1226 aa)
SMYD5SMYD family member 5. (416 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
YTHDC1YTH domain containing 1. (736 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (693 aa)
MORC2MORC family CW-type zinc finger 2. (1032 aa)
HDAC6Histone deacetylase 6. (1142 aa)
I3MNK6_ICTTRUncharacterized protein. (263 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (455 aa)
NRMNurim. (262 aa)
TASORTranscription activation suppressor. (1549 aa)
SIRT1Sirtuin 1. (602 aa)
SPTY2D1SPT2 chromatin protein domain containing 1. (685 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
MTA1Metastasis associated 1. (689 aa)
PADI2Peptidyl arginine deiminase 2. (674 aa)
EEDEmbryonic ectoderm development. (441 aa)
KMT2DLysine methyltransferase 2D. (5449 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
PABPC1LPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (574 aa)
ASIPAgouti signaling protein. (133 aa)
ARID4BAT-rich interaction domain 4B. (1316 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (432 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
RIF1Replication timing regulatory factor 1. (2480 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1698 aa)
RBM15BRNA binding motif protein 15B. (775 aa)
BAHD1Bromo adjacent homology domain containing 1. (779 aa)
NDNNecdin, MAGE family member. (325 aa)
LOC101954283-2Histone H3; Belongs to the histone H3 family. (136 aa)
BEND3BEN domain containing 3. (464 aa)
Dnmt3lPHD-type domain-containing protein. (358 aa)
CTCFCCCTC-binding factor. (727 aa)
TFAP2CTranscription factor AP-2 gamma. (419 aa)
ZNF335Zinc finger protein 335. (1371 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1905 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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